Free Cortisol | List of Frontiers open access articles

Mini Review

Published on 25 Sep 2025

CRF1 and ACTH inhibitors are a promising approach to treat obesity and leptin and insulin resistance

in Adrenal Endocrinology

Patricio H. Contreras
Henrik Falhammar

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1647028

3,350 views
1 citation

Original Research

Published on 23 Feb 2022

Ketoconazole- and Metyrapone-Induced Reductions on Urinary Steroid Metabolites Alter the Urinary Free Cortisol Immunoassay Reliability in Cushing Syndrome

in Pituitary Endocrinology

Arturo Vega-Beyhart
Javier Laguna-Moreno
Daniela Díaz-Catalán
Laura Boswell
Mireia Mora
Irene Halperin
Gregori Casals
Felicia A. Hanzu

Frontiers in Endocrinology

doi 10.3389/fendo.2022.833644

4,409 views
9 citations

Case Report

Published on 08 Feb 2024

Case report: Complete restoration of the HPA axis function in Cushing’s disease with drug treatment

in Neuroendocrine Science

Joanne Thanh-Tâm Nguyen
Amandine Ferrière
Antoine Tabarin

Frontiers in Endocrinology

doi 10.3389/fendo.2024.1337741

3,155 views
5 citations

Review

Published on 08 Nov 2019

Hypercortisolemia Recurrence in Cushing's Disease; a Diagnostic Challenge

in Pituitary Endocrinology

José Miguel Hinojosa-Amaya
Elena V. Varlamov
Shirley McCartney
Maria Fleseriu

Frontiers in Endocrinology

doi 10.3389/fendo.2019.00740

15,214 views
44 citations

Original Research

Published on 19 May 2023

Pregnancy complicated with adrenal adenoma causing ACTH-independent Cushing’s syndrome, accompanied by obstetric antiphospholipid syndrome and severe pre-eclampsia: case report and literature review

in Adrenal Endocrinology

Shenghan Xu
Miao Liu
Jiamu Xu
Bangwei Che
Wenjun Zhang
Wei Li
Tao Huang
Ying Yu
Cheng Zha
Zheng Peng

Frontiers in Endocrinology

doi 10.3389/fendo.2023.1147316

6,113 views
2 citations

Case Report

Published on 13 Aug 2020

High Molecular Weight ACTH-Precursor Presence in a Metastatic Pancreatic Neuroendocrine Tumor Causing Severe Ectopic Cushing's Syndrome: A Case Report

in Pituitary Endocrinology

Roopa Mehta
César Ernesto Lam-Chung
José Miguel Hinojosa-Amaya
Paola Roldán-Sarmiento
Maria Fernanda Guillen-Placencia
Gerladine Villanueva-Rodriguez
Oscar Alfredo Juarez-Leon
Jefsi Leon-Domínguez
Mariana Grajales-Gómez
Jose Luis Ventura-Gallegos

Frontiers in Endocrinology

doi 10.3389/fendo.2020.00557

4,709 views
3 citations

Case Report

Published on 04 Mar 2019

Factitious Cushing's Syndrome: A Diagnosis to Consider When Evaluating Hypercortisolism

in Pituitary Endocrinology

Maria M. Pineyro
Lia Redes
Sylvana De Mattos
Luciana Sanchez
Estefania Brignardello
Virginia Bianchi
Vanessa Ems
Dardo Centurión
Marcelo Viola

Frontiers in Endocrinology

doi 10.3389/fendo.2019.00129

17,548 views
11 citations

Case Report

Published on 27 Feb 2017

Medical Therapy with Pasireotide in Recurrent Cushing’s Disease: Experience of Patients Treated for At Least 1 Year at a Single Center

in Pituitary Endocrinology

Chris G. Yedinak
Sarah Hopkins
Jessica Williams
Aly Ibrahim
Justin Schultz Cetas
Maria Fleseriu

Frontiers in Endocrinology

doi 10.3389/fendo.2017.00035

4,018 views
8 citations

Original Research

Published on 19 Nov 2025

Morning spot urinary cortisol-to-creatinine ratio: a novel screening tool for assessing excess cortisol secretion

in Adrenal Endocrinology

Yingning Liu
Ping Zhang
Simin Zhang
Ying Gao
Yiqing Mu
Hong Lian
Qian Ren
Xiaoling Cai
Xianghai Zhou
Xueyao Han

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1663619

1,282 views

Review

Published on 08 Nov 2019

Toward a Diagnostic Score in Cushing's Syndrome

in Pituitary Endocrinology

Leah T. Braun
Anna Riester
Andrea Oßwald-Kopp
Julia Fazel
German Rubinstein
Martin Bidlingmaier
Felix Beuschlein
Martin Reincke

Frontiers in Endocrinology

doi 10.3389/fendo.2019.00766

26,110 views
73 citations

Original Research

Published on 26 Sep 2023

Intensity-modulated radiotherapy for cushing’s disease: single-center experience in 70 patients

in Pituitary Endocrinology

Xin Lian
Zhuoran Xu
Shuai Sun
Weiping Wang
Huijuan Zhu
Lin Lu
Xiaorong Hou
Fuquan Zhang

Frontiers in Endocrinology

doi 10.3389/fendo.2023.1241669

3,952 views
6 citations

Original Research

Published on 23 Aug 2023

Long-term efficacy and safety of osilodrostat in patients with Cushing’s disease: results from the LINC 4 study extension

in Pituitary Endocrinology

Mônica Gadelha
Peter J. Snyder
Przemysław Witek
Marie Bex
Zhanna Belaya
Adina F. Turcu
Richard A. Feelders
Anthony P. Heaney
Michaela Paul
Alberto M. Pedroncelli

Frontiers in Endocrinology

doi 10.3389/fendo.2023.1236465

10,150 views
38 citations

Original Research

Published on 06 Dec 2022

Steroid profiling using liquid chromatography mass spectrometry during adrenal vein sampling in patients with primary bilateral macronodular adrenocortical hyperplasia

in Adrenal Endocrinology

Ru Zhang
German Rubinstein
Sharmilee Vetrivel
Sonja Kunz
Frederick Vogel
Lucas Bouys
Jérôme Bertherat
Matthias Kroiss
Sinan Deniz
Andrea Osswald

Frontiers in Endocrinology

doi 10.3389/fendo.2022.1079508

4,517 views
2 citations

Original Research

Published on 02 Sep 2021

An Optimized Pathway for the Differential Diagnosis of ACTH-Dependent Cushing’s Syndrome Based on Low-Dose Dexamethasone Suppression Test

in Pituitary Endocrinology

Kang Chen
Shi Chen
Lin Lu
Huijuan Zhu
Xiaobo Zhang
Anli Tong
Hui Pan
Renzhi Wang
Zhaolin Lu

Frontiers in Endocrinology

doi 10.3389/fendo.2021.720823

7,541 views
11 citations

Clinical Trial

Published on 09 Oct 2023

Long-term efficacy and safety of subcutaneous pasireotide alone or in combination with cabergoline in Cushing’s disease

in Pituitary Endocrinology

Richard A. Feelders
Maria Fleseriu
Pinar Kadioglu
Marie Bex
Deyanira González-Devia
Cesar Luiz Boguszewski
Dilek Gogas Yavuz
Heather Patino
Alberto M. Pedroncelli
Ricardo Maamari

Frontiers in Endocrinology

doi 10.3389/fendo.2023.1165681

8,054 views
24 citations

Original Research

Published on 13 Nov 2025

Real-life data on pasireotide in monotherapy or combined in active Cushing’s disease

in Pituitary Endocrinology

Alessandro Mondin
Filippo Ceccato
Carla Scaroni
Luca Denaro
Renzo Manara
Umberto Maria Robertazzo
Mattia Barbot

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1695342

1,818 views

Articles

CRF1 and ACTH inhibitors are a promising approach to treat obesity and leptin and insulin resistance

Ketoconazole- and Metyrapone-Induced Reductions on Urinary Steroid Metabolites Alter the Urinary Free Cortisol Immunoassay Reliability in Cushing Syndrome

Case report: Complete restoration of the HPA axis function in Cushing’s disease with drug treatment

Hypercortisolemia Recurrence in Cushing's Disease; a Diagnostic Challenge

Pregnancy complicated with adrenal adenoma causing ACTH-independent Cushing’s syndrome, accompanied by obstetric antiphospholipid syndrome and severe pre-eclampsia: case report and literature review

High Molecular Weight ACTH-Precursor Presence in a Metastatic Pancreatic Neuroendocrine Tumor Causing Severe Ectopic Cushing's Syndrome: A Case Report

Factitious Cushing's Syndrome: A Diagnosis to Consider When Evaluating Hypercortisolism

Medical Therapy with Pasireotide in Recurrent Cushing’s Disease: Experience of Patients Treated for At Least 1 Year at a Single Center

Morning spot urinary cortisol-to-creatinine ratio: a novel screening tool for assessing excess cortisol secretion

Toward a Diagnostic Score in Cushing's Syndrome

Intensity-modulated radiotherapy for cushing’s disease: single-center experience in 70 patients

Long-term efficacy and safety of osilodrostat in patients with Cushing’s disease: results from the LINC 4 study extension

Steroid profiling using liquid chromatography mass spectrometry during adrenal vein sampling in patients with primary bilateral macronodular adrenocortical hyperplasia

An Optimized Pathway for the Differential Diagnosis of ACTH-Dependent Cushing’s Syndrome Based on Low-Dose Dexamethasone Suppression Test

Long-term efficacy and safety of subcutaneous pasireotide alone or in combination with cabergoline in Cushing’s disease

Real-life data on pasireotide in monotherapy or combined in active Cushing’s disease