Gene Optimization | List of Frontiers open access articles

Original Research

Published on 02 Mar 2026

The protease inhibitor gabexate mesylate targets Raf kinase inhibitor protein and reverses epithelial–mesenchymal transition in triple-negative breast cancer cells

in Breast Cancer

Marzia Deserti
Simone Sabbioni
Francesca Poli
Francesco Vasuri
Valeria Relli
Andrea Palloni
Chiara Deiana
Giovanni Brandi
Simona Tavolari

Frontiers in Oncology

doi 10.3389/fonc.2026.1713273

215 views

Original Research

Published on 02 Mar 2026

Macrophage-derived CCL20 promotes abdominal aortic aneurysm progression via lymphocytes CCR6

in Inflammation

Qingnan Ren
Tianyong Sun
Song Shen
Yuanbin Cao
Li Wei
Yang Zhao
Fengxin Wan
Ping Sui
Ke Xiao
Hao Bai

Frontiers in Immunology

doi 10.3389/fimmu.2026.1780720

Methods

Published on 02 Mar 2026

A missed opportunity: how signal detection theory can advance research on prejudice detection

in Organizational Justice, Diversity, Equity, Inclusion, and Belonging

Stephanie M. Merritt

Frontiers in Organizational Psychology

doi 10.3389/forgp.2026.1629459

164 views

Original Research

Published on 02 Mar 2026

Metabolic dysfunction-associated steatotic liver disease and bone mineral density in type 2 diabetes mellitus: insights from a single-center cross-sectional study in North India

in Bone Research

Dogga Sudhakar
Sumit Rajotiya
Sourav Debnath
Nishant Jain
Monal Sherekar
Shivang Mishra
Anurag Kumar Singh
Mahaveer Singh
Avinash Munshi
Deepak Nathiya

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1758966

Original Research

Published on 02 Mar 2026

Multimodal imaging features of non-proliferative and proliferative diabetic retinopathy based on SD-OCT and fundus autofluorescence

in Ophthalmology

Zixun Wang
Chenxi Ji
Xiaoxue Hu
Tingyu Zhang
Tingxi Liu
Xiaoling Zhang
Yuhang Wang
Zhiqing Li
Xiuhong Qin
Ming Sun

Frontiers in Medicine

doi 10.3389/fmed.2026.1779259

175 views

Policy Brief

Published on 02 Mar 2026

Restoring a sense of safety among survivors of sexual harassment in higher education: policy recommendations from the UNI4EQUITY multinational study

in Gender, Sex and Sexualities

Sylwia Jaskulska
Barbara Jankowiak
Vanesa Perez-Martrnez
Stefano Porru
Angela Carta
Marlies Wallner
Viktoria Stifter
Joana Topa
Iwetta Andruszkiewicz
Katarzyna Waszyńska

Frontiers in Sociology

doi 10.3389/fsoc.2026.1782978

Original Research

Published on 02 Mar 2026

Uric acid and hyperuricemia in relation to non-alcoholic fatty liver disease among individuals with type 2 diabetes: insights from a cross-sectional analysis

in Clinical Diabetes

Chunbo Li
Mengfan Zhang
Mengchun Li
Qifeng Shao

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1720601

Systematic Review

Published on 02 Mar 2026

Effects of different dosages of Sodium-glucose cotransporter 2 inhibitors on glucose level change in patients with type 2 diabetes stratified by HbA1c and renal function: a systematic review and meta-analysis

in Clinical Diabetes

Ruitong Xiong
Yucheng Yang
Yuxiu Li
Huabing Zhang

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1785329

Systematic Review

Published on 02 Mar 2026

The effects of multimodal lifestyle interventions on blood pressure, body weight, and waist circumference in hypertensive patients: a network meta-analysis

in Public Health and Nutrition

Ting Yao
Qiao Hu
Dongrui Miao
Zheyuan Xia
Miaomiao Li
Xiang Wang
Huiling Zhang

Frontiers in Public Health

doi 10.3389/fpubh.2026.1720695

205 views

Original Research

Published on 02 Mar 2026

The predictive value of surrogate insulin resistance indices for T2DM complicated with metabolic syndrome: a retrospective study based on hospitalized patients in China

in Clinical Diabetes

Sixu Xin
Xiaomei Zhang
Xin Zhao
Jianbin Sun

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1782071

Systematic Review

Published on 02 Mar 2026

Human umbilical cord mesenchymal stem cells therapy for Alzheimer’s disease: a systematic review and meta-analysis of mouse models

in Dementia and Neurodegenerative Diseases

Chunyan Si
Liang Ma
Wei Ding
Yunxia Tian
Jianping Zhang
Hua Cao
Ya Shao
Zhiqiang Fan

Frontiers in Neurology

doi 10.3389/fneur.2026.1783757

Review

Published on 02 Mar 2026

Disrupting PDGFRA-driven immune evasion in glioma: vaccine-based strategies on the horizon

in Neuro-Oncology and Neurosurgical Oncology

Xialin Zhang
Xinwei Li
Ran Cui
Xinlin Yu
Zihan Zhang
Zhongxiang Luo
Gang Chen
Sheng Lin

Frontiers in Oncology

doi 10.3389/fonc.2026.1666612

Review

Published on 02 Mar 2026

Vitamin D3 as an immunomodulatory agent: molecular mechanisms, clinical translation, and precision therapeutic strategies

in Nutritional Immunology

Qing Liu
Zhenzi Li
Shaojie Li
Yue Li
Haifeng Pan
Ye Tao

Frontiers in Immunology

doi 10.3389/fimmu.2026.1770141

125 views

Original Research

Published on 02 Mar 2026

Risk factors associated with solid oral tumors in dogs: a case–control study in São Paulo, Brazil

in Oncology in Veterinary Medicine

Marcella Collaneri Carrilho
Katia Pinello
Helena Sofia Salgueiro
Laura Sichero
Denner Santos dos Anjos
Guilherme da Silva Rogerio
Andrigo Barbosa de Nardi
Maria Lucia Zaidan Dagli

Frontiers in Veterinary Science

doi 10.3389/fvets.2026.1738835

Original Research

Published on 02 Mar 2026

Machine learning: predicting lymph node metastasis around the entrance point to the recurrent laryngeal nerve in cN0 papillary thyroid carcinoma

in Cancer Endocrinology

Jie Peng
Jing Zhou
Yuping Deng
Qian Xiao
Xinliang Su
Chang Deng

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1721148

Case Report

Published on 02 Mar 2026

Case Report: Synchronous primary high-grade appendiceal mucinous neoplasm and ovarian borderline mucinous cystadenoma: a rare case and diagnostic challenges

in Gastrointestinal Cancers: Colorectal Cancer

Long Chen
Yingyu Liu

Frontiers in Oncology

doi 10.3389/fonc.2026.1700388

Articles

The protease inhibitor gabexate mesylate targets Raf kinase inhibitor protein and reverses epithelial–mesenchymal transition in triple-negative breast cancer cells

Macrophage-derived CCL20 promotes abdominal aortic aneurysm progression via lymphocytes CCR6

A missed opportunity: how signal detection theory can advance research on prejudice detection

Metabolic dysfunction-associated steatotic liver disease and bone mineral density in type 2 diabetes mellitus: insights from a single-center cross-sectional study in North India

Multimodal imaging features of non-proliferative and proliferative diabetic retinopathy based on SD-OCT and fundus autofluorescence

Restoring a sense of safety among survivors of sexual harassment in higher education: policy recommendations from the UNI4EQUITY multinational study

Uric acid and hyperuricemia in relation to non-alcoholic fatty liver disease among individuals with type 2 diabetes: insights from a cross-sectional analysis

Effects of different dosages of Sodium-glucose cotransporter 2 inhibitors on glucose level change in patients with type 2 diabetes stratified by HbA1c and renal function: a systematic review and meta-analysis

The effects of multimodal lifestyle interventions on blood pressure, body weight, and waist circumference in hypertensive patients: a network meta-analysis

The predictive value of surrogate insulin resistance indices for T2DM complicated with metabolic syndrome: a retrospective study based on hospitalized patients in China

Human umbilical cord mesenchymal stem cells therapy for Alzheimer’s disease: a systematic review and meta-analysis of mouse models

Disrupting PDGFRA-driven immune evasion in glioma: vaccine-based strategies on the horizon

Vitamin D3 as an immunomodulatory agent: molecular mechanisms, clinical translation, and precision therapeutic strategies

Risk factors associated with solid oral tumors in dogs: a case–control study in São Paulo, Brazil

Machine learning: predicting lymph node metastasis around the entrance point to the recurrent laryngeal nerve in cN0 papillary thyroid carcinoma

Case Report: Synchronous primary high-grade appendiceal mucinous neoplasm and ovarian borderline mucinous cystadenoma: a rare case and diagnostic challenges