Generalized Lipodystrophy | List of Frontiers open access articles

Original Research

Published on 19 Sep 2018

Autoantibodies Against Perilipin 1 as a Cause of Acquired Generalized Lipodystrophy

in Autoimmune and Autoinflammatory Disorders

Fernando Corvillo
Verónica Aparicio
Alberto López-Lera
Sofía Garrido
David Araújo-Vilar
María P. de Miguel
Margarita López-Trascasa

Frontiers in Immunology

doi 10.3389/fimmu.2018.02142

7,553 views
42 citations

Case Report

Published on 18 Nov 2025

Case Report: Metreleptin treatment enables successful pregnancy in a female with congenital generalized lipodystrophy

in Clinical Diabetes

Maria Somali
Emmanouil Korakas
Eirini Pizirtzidou
Zoe A. Efstathiadou
Michail Sapranidis
Zadalla Mouslech

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1715799

1,334 views

Case Report

Published on 16 Dec 2025

Case Report: Generalized lipodystrophy following immune-checkpoint inhibitor therapy

in Clinical Diabetes

Andrew-Hyun Lee
Rina Hui
Jenny E. Gunton

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1710985

1,154 views

Case Report

Published on 23 Mar 2023

Case report: Echocardiographic diagnosis of cardiac involvement caused by congenital generalized lipodystrophy in an infant

in Pediatric Cardiology

Jie Zhou
Hanmin Liu
Jiao Chen
Xiaolan He

Frontiers in Pediatrics

doi 10.3389/fped.2023.1087833

2,139 views
1 citation

Case Report

Published on 28 Jun 2021

Misdiagnosis of Paget’s Disease of Bone in a Congenital Generalized Lipodystrophy Patient: Case Report

in Bone Research

Erika Bastos Lima Freire
Mayara Ponte Madeira
Grayce Ellen da Cruz Paiva Lima
Virginia Oliveira Fernandes
Lindenberg Barbosa Aguiar
João Paulo Uchoa Fontenele
Ana Paula Dias Rangel Montenegro
Thyciara Fontenele Marques
Renan Galvão Ozório
Catarina Brasil d’Alva

Frontiers in Endocrinology

doi 10.3389/fendo.2021.683697

9,718 views
2 citations

Case Report

Published on 06 Apr 2022

Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4

in Immunological Memory

Salvatore Zaffina
Eva Piano Mortari
Reparata Rosa Di Prinzio
Marco Cappa
Antonio Novelli
Emanuele Agolini
Massimiliano Raponi
Bruno Dallapiccola
Franco Locatelli
Carlo Federico Perno

Frontiers in Immunology

doi 10.3389/fimmu.2022.869042

3,158 views
4 citations

Original Research

Published on 03 Apr 2024

Heterogeneity and high prevalence of bone manifestations, and bone mineral density in congenital generalized lipodystrophy subtypes 1 and 2

in Bone Research

Erika Bastos Lima Freire
Catarina Brasil d’Alva
Mayara Ponte Madeira
Grayce Ellen da Cruz Paiva Lima
Virginia Oliveira Fernandes
Lindenberg Barbosa Aguiar
Leonardo Barreira Portella
Renan Galvão Ozório
Clarisse Mourão Melo Ponte
Ana Paula Dias Rangel Montenegro

Frontiers in Endocrinology

doi 10.3389/fendo.2024.1326700

3,630 views
5 citations

Mini Review

Published on 04 May 2022

Treatment Options for Lipodystrophy in Children

in Pediatric Endocrinology

Francesca Mainieri
Veronica Maria Tagi
Francesco Chiarelli

Frontiers in Endocrinology

doi 10.3389/fendo.2022.879979

8,048 views
9 citations

Original Research

Published on 21 May 2025

A real-world pharmacovigilance assessment and literature review of lymphoma development in lipodystrophy

in Cancer Endocrinology

Rebecca J. Brown
David Araujo-Vilar
Kelly J. Walkovich
Alexandru Barbarosie
David A. Magee
Baris Akinci
Elif A. Oral

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1582715

4,735 views
1 citation

Case Report

Published on 12 Jul 2023

A new mutation in the CAVIN1/PTRF gene in two siblings with congenital generalized lipodystrophy type 4: case reports and review of the literature

in Pediatric Endocrinology

Valentina Mancioppi
Tommaso Daffara
Martina Romanisio
Giovanni Ceccarini
Caterina Pelosini
Ferruccio Santini
Simonetta Bellone
Simona Mellone
Alessio Baricich
Ivana Rabbone

Frontiers in Endocrinology

doi 10.3389/fendo.2023.1212729

7,260 views
16 citations

Original Research

Published on 26 Jun 2024

Identification of ibuprofen targeting CXCR family members to alleviate metabolic disturbance in lipodystrophy based on bioinformatics and in vivo experimental verification

in Systems Endocrinology

Zhiwen Cao
Yuxiao Zhao
Ruixin Liu
Xialin Yan
Jiqiu Wang
Na Chen

Frontiers in Endocrinology

doi 10.3389/fendo.2024.1414908

3,388 views
1 citation

Case Report

Published on 13 Mar 2024

Case report: A novel splice-site mutation of MTX2 gene caused mandibuloacral dysplasia progeroid syndrome: the first report from China and literature review

in Bone Research

Xiaohui Fu
Shuli Chen
Xiao Huang
Qinghua Lu
Yunfei Cui
Weinan Lin
Qin Yang

Frontiers in Endocrinology

doi 10.3389/fendo.2024.1345067

4,183 views
3 citations

Articles

Autoantibodies Against Perilipin 1 as a Cause of Acquired Generalized Lipodystrophy

Case Report: Metreleptin treatment enables successful pregnancy in a female with congenital generalized lipodystrophy

Case Report: Generalized lipodystrophy following immune-checkpoint inhibitor therapy

Case report: Echocardiographic diagnosis of cardiac involvement caused by congenital generalized lipodystrophy in an infant

Misdiagnosis of Paget’s Disease of Bone in a Congenital Generalized Lipodystrophy Patient: Case Report

Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4

Heterogeneity and high prevalence of bone manifestations, and bone mineral density in congenital generalized lipodystrophy subtypes 1 and 2

Treatment Options for Lipodystrophy in Children

A real-world pharmacovigilance assessment and literature review of lymphoma development in lipodystrophy

A new mutation in the CAVIN1/PTRF gene in two siblings with congenital generalized lipodystrophy type 4: case reports and review of the literature

Identification of ibuprofen targeting CXCR family members to alleviate metabolic disturbance in lipodystrophy based on bioinformatics and in vivo experimental verification

Case report: A novel splice-site mutation of MTX2 gene caused mandibuloacral dysplasia progeroid syndrome: the first report from China and literature review