Glymphatic Clearance | List of Frontiers open access articles

Original Research

Published on 28 May 2025

Human immunodeficiency virus accelerates brain aging and disrupts the trajectory of glymphatic clearance in aging brain

in Psychopathology

Benedictor Alexander Nguchu
Jing Zhao
Yu Lu
Yifei Han
Han Jin
Xiaoxiao Wang
Hongjun Li
Peter Shaw

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1509093

3,236 views
1 citation

Hypothesis and Theory

Published on 08 Apr 2021

Rethinking the Conditions and Mechanism for Glymphatic Clearance

in Sleep and Circadian Rhythms

Craig F. Ferris

Frontiers in Neuroscience

doi 10.3389/fnins.2021.624690

9,255 views
31 citations

Mini Review

Accepted on 05 Feb 2026

"Mind the Gap" – Enlarged Perivascular Spaces as a Potential Magnetic Resonance Imaging Biomarker of Impaired Glymphatic Clearance in Brain Disorders

in Cellular Neuropathology

Claudia Francoise Eve Kirsch
Mackenzie Herb
Guarav Verma
Priti Balchandani

Frontiers in Cellular Neuroscience

Original Research

Published on 15 Aug 2025

Glymphatic system dysfunction in young adults hospitalized for an acute psychotic episode: a preliminary report from a pilot study

in Psychopathology

Tommaso Barlattani
Dalila De Luca
Sara Giambartolomei
Antony Bologna
Antonio Innocenzi
Federico Bruno
Valentina Socci
Maurizio Malavolta
Alessandro Rossi
Domenico de Berardis

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1653144

3,761 views
12 citations

Original Research

Published on 11 Oct 2016

Intracerebral Distribution of the Oncometabolite d-2-Hydroxyglutarate in Mice Bearing Mutant Isocitrate Dehydrogenase Brain Tumors: Implications for Tumorigenesis

in Neuro-Oncology and Neurosurgical Oncology

Amanda J. Pickard
Albert S. W. Sohn
Thomas F. Bartenstein
Shan He
Yi Zhang
James M. Gallo

Frontiers in Oncology

doi 10.3389/fonc.2016.00211

4,745 views
9 citations

Review

Published on 08 Apr 2024

Exploring neurodegenerative disorders using advanced magnetic resonance imaging of the glymphatic system

in Aging Psychiatry

Jannik Prasuhn
Jiadi Xu
Jun Hua
Peter van Zijl
Linda Knutsson

Frontiers in Psychiatry

doi 10.3389/fpsyt.2024.1368489

7,312 views
10 citations

Original Research

Published on 19 May 2017

Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice

in Molecular Signalling and Pathways

Xiao-fei He
Dong-xu Liu
Qun Zhang
Feng-ying Liang
Guang-yan Dai
Jin-sheng Zeng
Zhong Pei
Guang-qing Xu
Yue Lan

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2017.00144

38,886 views
335 citations

Review

Published on 18 Oct 2022

Perivascular spaces as a potential biomarker of Alzheimer’s disease

in Neurodegeneration

Miranda Lynch
William Pham
Benjamin Sinclair
Terence J. O’Brien
Meng Law
Lucy Vivash

Frontiers in Neuroscience

doi 10.3389/fnins.2022.1021131

13,421 views
56 citations

Review

Published on 23 Jul 2024

Association of circadian dysregulation with retinal degeneration and Alzheimer’s disease: a special focus on Muller glial cells

in Biophotonics

Glori Das
Thomas E. Milner

Frontiers in Photonics

doi 10.3389/fphot.2024.1389683

2,914 views
1 citation

Original Research

Published on 24 Jun 2022

The Association Between Glymphatic System Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease

in Neurocognitive Aging and Behavior

Jie Tang
Miaoyi Zhang
Na Liu
Yang Xue
Xue Ren
Qi Huang
Langfeng Shi
Jianhui Fu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2022.916633

14,271 views
88 citations

Original Research

Published on 20 Oct 2022

Perivascular spaces as a marker of disease severity and neurodegeneration in patients with behavioral variant frontotemporal dementia

in Neurodegeneration

Jasmine Moses
Benjamin Sinclair
Daniel L. Schwartz
Lisa C. Silbert
Terence J. O’Brien
Meng Law
Lucy Vivash

Frontiers in Neuroscience

doi 10.3389/fnins.2022.1003522

3,923 views
18 citations

Original Research

Published on 11 Mar 2022

Altered Glymphatic System in Middle-Aged cART-Treated Patients With HIV: A Diffusion Tensor Imaging Study

in Neuroinfectious Diseases

Benedictor Alexander Nguchu
Jing Zhao
Yanming Wang
Jean de Dieu Uwisengeyimana
Xiaoxiao Wang
Bensheng Qiu
Hongjun Li

Frontiers in Neurology

doi 10.3389/fneur.2022.819594

5,205 views
19 citations

Review

Published on 27 Mar 2025

Mechanistic insights into the sleep-glymphopathy-cerebral small vessel disease loop: implications for epilepsy pathophysiology and therapy

in Translational Neuroscience

Zaw Myo Hein
Zaid Adnan Subhi Al-Zaghal
Mazira Muhammad Ghazali
Usman Jaffer
Hafizah Abdul Hamid
Muhammad Zulfadli Mehat
Muhammad Danial Che Ramli
Che Mohd Nasril Che Mohd Nassir

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1546482

6,024 views
3 citations

Original Research

Published on 15 Feb 2023

Glymphatic system impairment in nonathlete older male adults who played contact sports in their youth associated with cognitive decline: A diffusion tensor image analysis along the perivascular space study

in Applied Neuroimaging

Yuichi Morita
Koji Kamagata
Christina Andica
Kaito Takabayashi
Junko Kikuta
Shohei Fujita
Thomas Samoyeau
Wataru Uchida
Yuya Saito
Hiroki Tabata

Frontiers in Neurology

doi 10.3389/fneur.2023.1100736

5,865 views
16 citations

Original Research

Published on 17 Jul 2025

The glymphatic system as a therapeutic target: TMS-induced modulation in older adults

in Neurocognitive Aging and Behavior

Mark H. Sundman
Yilin Liu
Nan-kuei Chen
Ying-hui Chou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1597311

4,427 views
3 citations

Original Research

Published on 13 May 2025

Multimodal neuroimaging investigation of post-stroke fatigue in middle-aged and older adults: combining resting-state fMRI and DTI-ALPS analysis

in Neurocognitive Aging and Behavior

Jingjing Sun
Yanlin Tang
Wenni Wang
Yong Zhang
Hengshan Ji
Peng Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1583655

3,784 views
1 citation

Articles

Human immunodeficiency virus accelerates brain aging and disrupts the trajectory of glymphatic clearance in aging brain

Rethinking the Conditions and Mechanism for Glymphatic Clearance

"Mind the Gap" – Enlarged Perivascular Spaces as a Potential Magnetic Resonance Imaging Biomarker of Impaired Glymphatic Clearance in Brain Disorders

Glymphatic system dysfunction in young adults hospitalized for an acute psychotic episode: a preliminary report from a pilot study

Intracerebral Distribution of the Oncometabolite d-2-Hydroxyglutarate in Mice Bearing Mutant Isocitrate Dehydrogenase Brain Tumors: Implications for Tumorigenesis

Exploring neurodegenerative disorders using advanced magnetic resonance imaging of the glymphatic system

Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice

Perivascular spaces as a potential biomarker of Alzheimer’s disease

Association of circadian dysregulation with retinal degeneration and Alzheimer’s disease: a special focus on Muller glial cells

The Association Between Glymphatic System Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease

Perivascular spaces as a marker of disease severity and neurodegeneration in patients with behavioral variant frontotemporal dementia

Altered Glymphatic System in Middle-Aged cART-Treated Patients With HIV: A Diffusion Tensor Imaging Study

Mechanistic insights into the sleep-glymphopathy-cerebral small vessel disease loop: implications for epilepsy pathophysiology and therapy

Glymphatic system impairment in nonathlete older male adults who played contact sports in their youth associated with cognitive decline: A diffusion tensor image analysis along the perivascular space study

The glymphatic system as a therapeutic target: TMS-induced modulation in older adults

Multimodal neuroimaging investigation of post-stroke fatigue in middle-aged and older adults: combining resting-state fMRI and DTI-ALPS analysis