Hard Problems | List of Frontiers open access articles

Brief Research Report

Accepted on 09 Mar 2026

Mortars containing eucalyptus wood ash and sewage sludge: eco-efficiency optimization using a central composite design and the desirability function

in Sustainable Design and Construction

Roziani Maria Gomes
José Maria Franco De Carvalho
Gustavo Henrique Nalon
Hellen Regina de Carvalho Veloso Moura
Flávio Antônio Ferreira
Antônio Cléber Gonçalves Tibiriçá
José Carlos Lopes Ribeiro

Frontiers in Built Environment

Review

Accepted on 09 Mar 2026

Digital Technologies for Sustainable Food Supply Chains: A Scoping Review of Impacts on Food Safety, Loss Reduction, and Implications for Nutritional Security

in Nutrition and Food Science Technology

Shuang Li
Haoyang Li
Tianyi Kong

Frontiers in Nutrition

Review

Accepted on 09 Mar 2026

Innovative Pedagogies Across the Education Spectrum: A Comprehensive Review of Practices, Systemic Challenges, and Health Implications from Early Childhood to Higher Education

in Mental Health and Wellbeing in Education

Mohammad Abuzar Shaikh
Reshma Yerunkar
Jayshree Patil
ziyaul haque

Frontiers in Education

Original Research

Accepted on 09 Mar 2026

Executive function and language: A behavioural and functional near-infrared spectroscopy (fNIRS) study in twenty-three normally hearing children and one deaf child with cochlear implants

in Speech and Language

Rachael Lawrence
Efstratia Papoutselou
Guangting Mai
Ian Michael Wiggins
Douglas Edward Hugh Hartley

Frontiers in Human Neuroscience

Original Research

Accepted on 09 Mar 2026

Invisible Scars, Collapsed Trust: A Mixed-Methods Inquiry into the Cognitive-Empathic Divide in School Bullying and a Systemic Intervention Framework

in Mental Health and Wellbeing in Education

Binbin Mao
jinan jia

Frontiers in Education

Original Research

Accepted on 09 Mar 2026

Manuka Honey as a Natural Remedy for Diabetic Foot Ulcers: Efficacy Compared with Silver-Based Dressing

in Ethnopharmacology

Ewa Rojczyk
Kinga Spyrka
Aleksander Sieroń
Dariusz Bazaliński
Marek Kucharzewski

Frontiers in Pharmacology

Case Report

Accepted on 09 Mar 2026

Successful treatment of primary mediastinal malignant germ cell tumor with multiple systemic metastases in children using multi-drug combination chemotherapy: A rare case report

in Pharmacology of Anti-Cancer Drugs

Yang-Yang Jiao
Yan-Hua Li
Xue-Lian Liao
Jing-Bo Shao
Ting Zhang
Jing-Wei Yang
Can Huang
Wen-Yan Huang
Sha-Yi Jiang

Frontiers in Pharmacology

Review

Accepted on 09 Mar 2026

The Transformative Impact of AI-enabled AlphaFold 3: Evolution, Current status, and Future prospect in Structural Biology

in Medicine and Public Health

Chiranjib Chakraborty
Manojit Bhattacharya
Sang-Soo Lee

Frontiers in Artificial Intelligence

Case Report

Accepted on 09 Mar 2026

Durable Response to FOLFOX Plus Serplulimab in AFP-Producing Gastric Adenocarcinoma With Liver Metastases: A Case Report and literature review

in Cancer Immunity and Immunotherapy

Jin Yuqi
Linglin Fu
Yuhan Zhao
Yinuo Tan

Frontiers in Immunology

Original Research

Accepted on 09 Mar 2026

Urban flooding analysis for Event Reconstruction in Historical Cities: The Case Study of Matera (Italy)

in Urban Science

Silvano Fortunato Dal Sasso
Giovanna Andrulli
Vito Cambio
Leonardo Mita
Muhammad Asif
Vincenzo Totaro
Raffaele Albano

Frontiers in Built Environment

Original Research

Accepted on 09 Mar 2026

A TNNT2 variant in a Sporadic Case of Dilated Cardiomyopathy: A Case Report and Review

in Cardiovascular Genetics and Systems Medicine

Xinglin 陈星霖 Chen
Zhengjie 黄正杰 Huang
Qi 郑琦 Zheng
Lingfeng 查灵凤 Zha
Tingting 唐婷婷 Tang
Xiang 程翔 Cheng

Frontiers in Cardiovascular Medicine

Original Research

Accepted on 09 Mar 2026

Post-marketing safety evaluation of anthracycline for acute myeloid leukemia treatment: a real-world pharmacovigilance analysis

in Pharmacoepidemiology

Hongchun Qiu
Yong Wang
Qian Liu
Jing Xu
Fei Yang
Meiyan Wang
Haoxiang Lu
Jie Wu
Ao Zhang
Xingli Zhang

Frontiers in Pharmacology

Opinion

Accepted on 09 Mar 2026

Fatal Deception: How Generative AI Fosters Therapeutic Misconception in Vulnerable Users

in Digital Mental Health

Jean-Christophe Bélisle-Pipon

Frontiers in Digital Health

Original Research

Accepted on 09 Mar 2026

PRIMED: Predicting DNA Binding Residues by Leveraging Pre-trained Protein Language Models

in Medicine and Public Health

Luoshu Zhang
Xin Li
Ruocen Song
Xiao Fan

Frontiers in Artificial Intelligence

Original Research

Accepted on 09 Mar 2026

High Cognitive Reserve Sustains Neurocognitive Resilience in Medical Education Twenty Months After COVID-19

in Mental Health and Wellbeing in Education

Beatriz Fajone Silva Duarte
Carolina Santos Madia
Aissa Sanches Rufino
Camila Pereira Braghin
Felipe Viegas Rodrigues

Frontiers in Education

Original Research

Accepted on 09 Mar 2026

Association between Controlling Nutritional Status (CONUT) and all-cause mortality in elderly hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease: A Retrospective Cohort Study

in Clinical Nutrition

Shujiao Li
Mingzhe Wang
Jun Yan
Chengjun Ban

Frontiers in Nutrition

Articles

Mortars containing eucalyptus wood ash and sewage sludge: eco-efficiency optimization using a central composite design and the desirability function

Digital Technologies for Sustainable Food Supply Chains: A Scoping Review of Impacts on Food Safety, Loss Reduction, and Implications for Nutritional Security

Innovative Pedagogies Across the Education Spectrum: A Comprehensive Review of Practices, Systemic Challenges, and Health Implications from Early Childhood to Higher Education

Executive function and language: A behavioural and functional near-infrared spectroscopy (fNIRS) study in twenty-three normally hearing children and one deaf child with cochlear implants

Invisible Scars, Collapsed Trust: A Mixed-Methods Inquiry into the Cognitive-Empathic Divide in School Bullying and a Systemic Intervention Framework

Manuka Honey as a Natural Remedy for Diabetic Foot Ulcers: Efficacy Compared with Silver-Based Dressing

Successful treatment of primary mediastinal malignant germ cell tumor with multiple systemic metastases in children using multi-drug combination chemotherapy: A rare case report

The Transformative Impact of AI-enabled AlphaFold 3: Evolution, Current status, and Future prospect in Structural Biology

Durable Response to FOLFOX Plus Serplulimab in AFP-Producing Gastric Adenocarcinoma With Liver Metastases: A Case Report and literature review

Urban flooding analysis for Event Reconstruction in Historical Cities: The Case Study of Matera (Italy)

A TNNT2 variant in a Sporadic Case of Dilated Cardiomyopathy: A Case Report and Review

Post-marketing safety evaluation of anthracycline for acute myeloid leukemia treatment: a real-world pharmacovigilance analysis

Fatal Deception: How Generative AI Fosters Therapeutic Misconception in Vulnerable Users

PRIMED: Predicting DNA Binding Residues by Leveraging Pre-trained Protein Language Models

High Cognitive Reserve Sustains Neurocognitive Resilience in Medical Education Twenty Months After COVID-19

Association between Controlling Nutritional Status (CONUT) and all-cause mortality in elderly hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease: A Retrospective Cohort Study