Hyper Inflammation | List of Frontiers open access articles

Review

Published on 14 Jul 2020

Targeting the Heme Oxygenase 1/Carbon Monoxide Pathway to Resolve Lung Hyper-Inflammation and Restore a Regulated Immune Response in Cystic Fibrosis

in Inflammation Pharmacology

Caterina Di Pietro
Hasan H. Öz
Thomas S. Murray
Emanuela M. Bruscia

Frontiers in Pharmacology

doi 10.3389/fphar.2020.01059

9,045 views
33 citations

Original Research

Published on 07 Nov 2019

Siglec-G Deficiency Ameliorates Hyper-Inflammation and Immune Collapse in Sepsis via Regulating Src Activation

in Inflammation

Wenqian Li
Yinjiao Li
Kewei Qin
Boxiang Du
Tianliang Li
Hongbin Yuan
Chaofeng Han
Yan Luo

Frontiers in Immunology

doi 10.3389/fimmu.2019.02575

7,644 views
19 citations

Original Research

Published on 24 Apr 2023

Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells

in Aging and Cancer

Ibrahim Y. Abdelgawad
Kevin Agostinucci
Bushra Sadaf
Marianne K. O. Grant
Beshay N. Zordoky

Frontiers in Aging

doi 10.3389/fragi.2023.1170434

11,464 views
42 citations

Review

Published on 21 Feb 2022

Dichotomous Role of Tumor Necrosis Factor in Pulmonary Barrier Function and Alveolar Fluid Clearance

in Respiratory Physiology and Pathophysiology

Rudolf Lucas
Yalda Hadizamani
Perenlei Enkhbaatar
Gabor Csanyi
Robert W. Caldwell
Harald Hundsberger
Supriya Sridhar
Alice Ann Lever
Martina Hudel
Dipankar Ash

Frontiers in Physiology

doi 10.3389/fphys.2021.793251

12,059 views
33 citations

Review

Published on 16 Jun 2021

Macrophage Related Chronic Inflammation in Non-Healing Wounds

in Inflammation

Meirong Li
Qian Hou
Lingzhi Zhong
Yali Zhao
Xiaobing Fu

Frontiers in Immunology

doi 10.3389/fimmu.2021.681710

33,865 views
263 citations

Review

Published on 03 Jul 2023

Regulation of inflammation and immunity in sepsis by E3 ligases

in Cellular Endocrinology

Shasha Shao
Daixing Zhou
Jun Feng
Yanyan Liu
Baturuhu
Huimei Yin
Daqian Zhan

Frontiers in Endocrinology

doi 10.3389/fendo.2023.1124334

5,776 views
12 citations

Review

Published on 16 Mar 2023

Serum amyloid A—A potential therapeutic target for hyper-inflammatory syndrome associated with COVID-19

in Translational Medicine

Eman M. Almusalami
Anthony Lockett
Albert Ferro
John Posner

Frontiers in Medicine

doi 10.3389/fmed.2023.1135695

6,117 views
20 citations

Original Research

Accepted on 11 Feb 2026

Klebsiella pneumoniae Infection Induces an S100A8/A9-Mediated Autocrine Loop in Human Airway Epithelium to Amplify Inflammation

in Infectious Agents and Disease

Jie Zheng
Xiuchan Feng
Qianrui Zeng
Shutong Chen
Caihong Yan
Zhijia Huang

Frontiers in Microbiology

Original Research

Published on 28 Nov 2025

Lung microbiome signatures and explainable predictive modeling of glucocorticoid response in severe community acquired pneumonia

in Infectious Agents and Disease

Yeong-Nan Cheng
Guan-Ting Chen
Wei-Chih Huang
Yen-Peng Chiu
Yun Tang
Pin-Kuei Fu
Tzong-Yi Lee

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1706432

1,651 views

Review

Published on 21 Nov 2017

Modulating Host Signaling Pathways to Promote Resistance to Infection by Candida albicans

in Fungal Pathogenesis

Nick Carpino
Shamoon Naseem
David M. Frank
James B. Konopka

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2017.00481

6,507 views
25 citations

Hypothesis and Theory

Published on 01 Feb 2021

Cytokine Storm as a Cellular Response to dsDNA Breaks: A New Proposal

in Inflammation

Snehal Shabrish
Indraneel Mittra

Frontiers in Immunology

doi 10.3389/fimmu.2021.622738

7,926 views
15 citations

Perspective

Published on 05 Dec 2022

Boolean modeling reveals that cyclic attractors in macrophage polarization serve as reservoirs of states to balance external perturbations from the tumor microenvironment

in Systems Immunology

Ugo Avila-Ponce de León
Aarón Vázquez-Jiménez
Meztli Matadamas-Guzmán
Osbaldo Resendis-Antonio

Frontiers in Immunology

doi 10.3389/fimmu.2022.1012730

3,301 views
8 citations

Review

Published on 29 Nov 2018

Sepsis-Induced Immunosuppression in Neonates

in Neonatology

Julie E. Hibbert
Andrew Currie
Tobias Strunk

Frontiers in Pediatrics

doi 10.3389/fped.2018.00357

12,446 views
63 citations

Review

Published on 29 Apr 2022

Oxidative Stress and Hyper-Inflammation as Major Drivers of Severe COVID-19 and Long COVID: Implications for the Benefit of High-Dose Intravenous Vitamin C

in Inflammation Pharmacology

Claudia Vollbracht
Karin Kraft

Frontiers in Pharmacology

doi 10.3389/fphar.2022.899198

28,643 views
140 citations

Original Research

Published on 29 Apr 2021

Respiratory Impairment Predicts Response to IL-1 and IL-6 Blockade in COVID-19 Patients With Severe Pneumonia and Hyper-Inflammation

in Viral Immunology

Emanuel Della-Torre
Marco Lanzillotta
Corrado Campochiaro
Giulio Cavalli
Giacomo De Luca
Alessandro Tomelleri
Nicola Boffini
Rebecca De Lorenzo
Annalisa Ruggeri
Patrizia Rovere-Querini

Frontiers in Immunology

doi 10.3389/fimmu.2021.675678

6,636 views
46 citations

Original Research

Published on 24 Jun 2021

A Computational Approach Identified Andrographolide as a Potential Drug for Suppressing COVID-19-Induced Cytokine Storm

in Nutritional Immunology

Mohd Rehan
Firoz Ahmed
Saad M. Howladar
Mohammed Y. Refai
Hanadi M. Baeissa
Torki A. Zughaibi
Khalid Mohammed Kedwa
Mohammad Sarwar Jamal

Frontiers in Immunology

doi 10.3389/fimmu.2021.648250

12,298 views
34 citations

Articles

Targeting the Heme Oxygenase 1/Carbon Monoxide Pathway to Resolve Lung Hyper-Inflammation and Restore a Regulated Immune Response in Cystic Fibrosis

Siglec-G Deficiency Ameliorates Hyper-Inflammation and Immune Collapse in Sepsis via Regulating Src Activation

Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells

Dichotomous Role of Tumor Necrosis Factor in Pulmonary Barrier Function and Alveolar Fluid Clearance

Macrophage Related Chronic Inflammation in Non-Healing Wounds

Regulation of inflammation and immunity in sepsis by E3 ligases

Serum amyloid A—A potential therapeutic target for hyper-inflammatory syndrome associated with COVID-19

Klebsiella pneumoniae Infection Induces an S100A8/A9-Mediated Autocrine Loop in Human Airway Epithelium to Amplify Inflammation

Lung microbiome signatures and explainable predictive modeling of glucocorticoid response in severe community acquired pneumonia

Modulating Host Signaling Pathways to Promote Resistance to Infection by Candida albicans

Cytokine Storm as a Cellular Response to dsDNA Breaks: A New Proposal

Boolean modeling reveals that cyclic attractors in macrophage polarization serve as reservoirs of states to balance external perturbations from the tumor microenvironment

Sepsis-Induced Immunosuppression in Neonates

Oxidative Stress and Hyper-Inflammation as Major Drivers of Severe COVID-19 and Long COVID: Implications for the Benefit of High-Dose Intravenous Vitamin C

Respiratory Impairment Predicts Response to IL-1 and IL-6 Blockade in COVID-19 Patients With Severe Pneumonia and Hyper-Inflammation

A Computational Approach Identified Andrographolide as a Potential Drug for Suppressing COVID-19-Induced Cytokine Storm