Intractable Problems | List of Frontiers open access articles

Original Research

Accepted on 02 Mar 2026

Multi-omics integration and machine learning reveal gut-immune signatures in idiopathic pulmonary fibrosis: insights from bulk RNA-seq, single-cell profiles, spatial transcriptomics, and experimental validation

in Inflammation

Zhengyu Hu
Jiaqi Wang
Jialin Yu
Zheqing Hu
Jing Xue
Zhanbing Ma
Miaomiao Nian
Ruixin Qi
Tingting Zhao
Xia Cao

Frontiers in Immunology

Original Research

Accepted on 02 Mar 2026

Molecular Characterization of ESBL-Producing Escherichia coli from UTIs and Antimicrobial Activity of Biosynthesized Selenium Nanocomposites

in Antibiotic Resistance and New Antimicrobial drugs

Heba A. Ahmed
Abdulraouf Almohammadi
Noha Anwar
Eman Ariny
Nashwa El-Gazzar

Frontiers in Cellular and Infection Microbiology

Original Research

Accepted on 02 Mar 2026

Reconfiguring Agency under Platform Governance: Baby Boomer and Generation X Singers Negotiating Identity, Algorithms, and Monetization

in Media Governance and the Public Sphere

Ashanti Hastuti
Suko Widodo
Fendy Suhariadi

Frontiers in Sociology

Systematic Review

Accepted on 02 Mar 2026

Comparative Efficacy and Safety of Dexmedetomidine vs. Midazolam in Adult Patients: A Meta-Analysis

in Intensive Care Medicine and Anesthesiology

Chen Na
Tian Ting
Li Li

Frontiers in Medicine

Original Research

Accepted on 02 Mar 2026

Perioperative Hypersensitivity Reactions: Retrospective Study (2018–2023) in a Lebanese Tertiary Clinic

in Pharmacogenetics and Pharmacogenomics

Diane Antonios
Guitta Badran
Viviane Chalhoub
Luc De Chaisemartin
Pascale NICAISE ROLAND
Sylvie Chollet-Martin
Marc Pallardy
Hayat Azouri
Carla Irani

Frontiers in Pharmacology

Editorial

Accepted on 02 Mar 2026

Editorial: Biomarker-driven strategies for personalized management of systemic inflammatory response syndrome

in Cytokines and Soluble Mediators in Immunity

Sara Bobillo-Perez
Iolanda Jordan
Bernhard RYFFEL

Frontiers in Immunology

Original Research

Accepted on 02 Mar 2026

Research on the Integration Development Model of "Language + Culture + Tourism + Older adults Care" Based on Digital Technology

in Aging and Public Health

Rui Wang
HONG TIAN

Frontiers in Public Health

Original Research

Accepted on 02 Mar 2026

Mindfulness-Based Controlled Breathing and the Effect on Performing a Transnasal Endoscopy: A Quasi-Experimental Study

in Gastroenterology

LEI SUN
Xiaona Sun
Zhishen Zhang
Xinyi zhang

Frontiers in Medicine

Original Research

Accepted on 02 Mar 2026

Shifting Perspectives on the Role of Parents in the Rehabilitation of Children with higher body weight: Insights from Qualitative Interviews with Children, Parents, and Professionals

in Pediatric Obesity

Lucia Schlottner
Lucie Schröder
Sandra Fahrenkrog
Judith Stumm

Frontiers in Pediatrics

Original Research

Accepted on 02 Mar 2026

Identification of Herbal Formula Huatanqushihuoxue Formula as a Potential Therapeutic Agent for Metabolism-related fatty liver disease: A Multi-Omics and Network Pharmacology Approach

in Inflammation

Sutong Liu
Lihui Zhang
Wanyi Zhu
Weichen Ma
Qing Zao
Minghao Liu
Wenxia Zhao

Frontiers in Immunology

Review

Accepted on 02 Mar 2026

The AMP–Antibiotic–Microbiota Triad in IBD: A Mechanistic Framework for Dysregulated Antimicrobial Defense

in Mucosal Immunity

Yuyuan Hu
Yan Li
Qiang Zhang
Qiaobo Tan
Haoze Liu
Yuhang Yang
晨飞晋
Wei Zhang
Hanhan Jia
Jinxi Wang

Frontiers in Immunology

Review

Accepted on 02 Mar 2026

Advancements in Thin Film Thermoelectric: Progress and Perspective on Materials and Devices

in Thermoelectric and Energy-Harvesting Materials

Nurfarhana Ahmad Musri
Angella Th’ng
Izzah Hanim Abd Aziz
Ubaidah Syafiq

Frontiers in Electronic Materials

Original Research

Accepted on 02 Mar 2026

First report on the biological characteristics of carbapenem-resistant Salmonella Thompson with blaCMY-2 production combined with OmpC and OmpF outer membrane protein deficiency in bloodstream infection

in Molecular Bacterial Pathogenesis

Chunhong Shao
Guangfei Zhou
Yanyan Sang
Xinying Wang
Lingling Wu
Zhijun Zhang

Frontiers in Cellular and Infection Microbiology

Original Research

Accepted on 02 Mar 2026

Upregulation of innate and adaptive immune mechanisms facilitating prevention of gastric Helicobacter pylori infection in guinea pigs by per os administration of chitosan microparticles loaded with Mycobacterium bovis BCG

in Microbial Immunology

Weronika Gonciarz
Marek Brzeziński
Agnieszka Wosiak
Agnieszka Jeleń
Ewa Balcerczak
Magdalena Chmiela

Frontiers in Immunology

Systematic Review

Accepted on 02 Mar 2026

Safety and Efficacy of Major Antiviral and Immune Therapies in Pregnancy For Maternal Viral Infections: Evidence Synthesis of Maternal and Neonatal Outcomes

in Infectious Diseases: Pathogenesis and Therapy

Sirwan Sleman
Omed I. Abid
Barham J. Abdullah
Zaniar A. Abass
Masood B. Ameen

Frontiers in Medicine

Review

Accepted on 02 Mar 2026

Lipid Metabolism-MAFLD Crosstalk: Mechanisms and Therapy

in Experimental Endocrinology

Bo Jia Li
Shengai Piao
Yin Fu
Qiang Fu
Peiyao Qin
Weitai Kong
Yidi Ma
Zhe Zhang
Xue Fan
Xiaoyang Hu

Frontiers in Endocrinology

Articles

Multi-omics integration and machine learning reveal gut-immune signatures in idiopathic pulmonary fibrosis: insights from bulk RNA-seq, single-cell profiles, spatial transcriptomics, and experimental validation

Molecular Characterization of ESBL-Producing Escherichia coli from UTIs and Antimicrobial Activity of Biosynthesized Selenium Nanocomposites

Reconfiguring Agency under Platform Governance: Baby Boomer and Generation X Singers Negotiating Identity, Algorithms, and Monetization

Comparative Efficacy and Safety of Dexmedetomidine vs. Midazolam in Adult Patients: A Meta-Analysis

Perioperative Hypersensitivity Reactions: Retrospective Study (2018–2023) in a Lebanese Tertiary Clinic

Editorial: Biomarker-driven strategies for personalized management of systemic inflammatory response syndrome

Research on the Integration Development Model of "Language + Culture + Tourism + Older adults Care" Based on Digital Technology

Mindfulness-Based Controlled Breathing and the Effect on Performing a Transnasal Endoscopy: A Quasi-Experimental Study

Shifting Perspectives on the Role of Parents in the Rehabilitation of Children with higher body weight: Insights from Qualitative Interviews with Children, Parents, and Professionals

Identification of Herbal Formula Huatanqushihuoxue Formula as a Potential Therapeutic Agent for Metabolism-related fatty liver disease: A Multi-Omics and Network Pharmacology Approach

The AMP–Antibiotic–Microbiota Triad in IBD: A Mechanistic Framework for Dysregulated Antimicrobial Defense

Advancements in Thin Film Thermoelectric: Progress and Perspective on Materials and Devices

First report on the biological characteristics of carbapenem-resistant Salmonella Thompson with blaCMY-2 production combined with OmpC and OmpF outer membrane protein deficiency in bloodstream infection

Upregulation of innate and adaptive immune mechanisms facilitating prevention of gastric Helicobacter pylori infection in guinea pigs by per os administration of chitosan microparticles loaded with Mycobacterium bovis BCG

Safety and Efficacy of Major Antiviral and Immune Therapies in Pregnancy For Maternal Viral Infections: Evidence Synthesis of Maternal and Neonatal Outcomes

Lipid Metabolism-MAFLD Crosstalk: Mechanisms and Therapy