Intractable Problems | List of Frontiers open access articles

Original Research

Accepted on 28 Feb 2026

Systemic Metabolic Dysfunction is Associated with Local Treatment Failure: The Role of Visceral Adiposity Index in Anti-VEGF Resistance in Diabetic Macular Edema

in Clinical Diabetes

Mi Chen
Jiang Ting
Changbo Hu

Frontiers in Endocrinology

Original Research

Accepted on 28 Feb 2026

Assessing the Association of FIB-4 Index with Diabetic Kidney Disease in Patients with Diabetes Mellitus: A Cross-Sectional and Retrospective Study Utilizing NHANES and Clinical Data

in Clinical Diabetes

Ronglu Yang
Yongjun Liu
Jinhu Li

Frontiers in Endocrinology

Editorial

Accepted on 28 Feb 2026

Editorial: Natural Antioxidants and Cardiovascular Diseases: A Pathway to Prevention

in Cardiovascular Biologics and Regenerative Medicine

Roberta Giordo
Anna Maria Posadino

Frontiers in Cardiovascular Medicine

Original Research

Accepted on 28 Feb 2026

Reconstructing the Evolution of Fault Activity in Feidong, Anhui Province by Integrating Multimodal Deep Learning and Geological Big Data

in Geoinformatics

Fang Yuan

Frontiers in Earth Science

Original Research

Accepted on 28 Feb 2026

A FAERS Database Study on Visual Impairment Adverse Events Associated with Three Long-Acting Insulin Analogues

in Clinical Diabetes

Li Zhong
Wenxuan Cao
Xinyu Liu
Tiancai Wen
Jing Yan

Frontiers in Endocrinology

Original Research

Accepted on 28 Feb 2026

Predicting sight-threatening diabetic retinopathy using the combination of serum cystatin C and indirect bilirubin

in Clinical Diabetes

Yujie Yan
Lulu Song
Yangyang Xu
Shancheng Si

Frontiers in Endocrinology

Systematic Review

Accepted on 28 Feb 2026

The Rise and Evolution of Cancer Mechanobiology: A Bibliometric Trajectory of Three Decades of Research

in Pharmacology of Anti-Cancer Drugs

Boyan Liu
Xufeng Liu
Yue Wang
Xiao Han
Xiyu Dang

Frontiers in Pharmacology

Mini Review

Accepted on 28 Feb 2026

In-Process Analytics for IVT mRNA Manufacturing: From Process Understanding to Advanced Process Control

in Cell and Gene Therapy

Naryeong Kim
Emily Dong
Kate Tschudi
Julien Camperi

Frontiers in Bioengineering and Biotechnology

Original Research

Accepted on 28 Feb 2026

An Integrative Pharmacovigilance, Network Toxicology and Molecular Docking Study on Drug-Induced Cheilitis

in Pharmacoepidemiology

Xuefeng Wang
Shangzhi Han
Yingxue Huang
Lei Zhang
Xue Li
Liqin Yang
Yanbo Zhang

Frontiers in Pharmacology

Review

Accepted on 28 Feb 2026

Selection of Beneficial Fungi for Plants with the Potential to Metabolize Lunar and Martian Regolith

in Astrobiology

Jessica C Oliveira
Rafael Loureiro
Andrew George Palmer
Camila M Patreze

Frontiers in Astronomy and Space Sciences

Conceptual Analysis

Accepted on 28 Feb 2026

Towards LLM-Aware Software Effort Estimation: A Conceptual Framework

in Machine Learning and Artificial Intelligence

Feisal Alaswad
Poovammal E
Batoul Aljaddouh

Frontiers in Artificial Intelligence

Original Research

Accepted on 28 Feb 2026

Circulating fatty acids and risk of Gastrointestinal cancer in the UK Biobank

in Clinical Nutrition

Yuan Liu
Zhu Zhu
Chuang Yang

Frontiers in Nutrition

Review

Accepted on 28 Feb 2026

Cancer cells metastasize in several types of cancer via two distinct routes, probably based on mechanical signals

in Cell Adhesion and Migration

Claudia Tanja Mierke

Frontiers in Cell and Developmental Biology

Original Research

Accepted on 28 Feb 2026

Linagliptin loaded chitosan nanoparticles for the efficient therapy of renal fibrosis

in Translational Pharmacology

Zhixiang Wu
Yanjuan He
Hao Deng
Yue Tan
Wangzi Gao
Jiaxin Yin
Ziqin Zeng
Jing Sun
Lijuan Zhang
Yue Li

Frontiers in Pharmacology

Original Research

Accepted on 28 Feb 2026

Knowledge, Attitudes, and Practices Regarding Nasopharyngeal Carcinoma among Young Adults and Students in Southern China: A Cross-Sectional Study

in Cancer Epidemiology and Prevention

Yehua Dai
Liping Jiang
Liping Qi
Meidan Cai
Dingke Liu
Ting Wang
Linzhi Kang
Ruijie Yang
Xin Huang

Frontiers in Oncology

Original Research

Accepted on 28 Feb 2026

Developing Ecological Compensation Standards for WaterResources: Evidence from the Enshi Section of the Qingjiang River Basin

in Environmental Economics and Management

Yujie Wei
Zixi Xu
Ran Wang
Chenxi Ye

Frontiers in Environmental Science

Articles

Systemic Metabolic Dysfunction is Associated with Local Treatment Failure: The Role of Visceral Adiposity Index in Anti-VEGF Resistance in Diabetic Macular Edema

Assessing the Association of FIB-4 Index with Diabetic Kidney Disease in Patients with Diabetes Mellitus: A Cross-Sectional and Retrospective Study Utilizing NHANES and Clinical Data

Editorial: Natural Antioxidants and Cardiovascular Diseases: A Pathway to Prevention

Reconstructing the Evolution of Fault Activity in Feidong, Anhui Province by Integrating Multimodal Deep Learning and Geological Big Data

A FAERS Database Study on Visual Impairment Adverse Events Associated with Three Long-Acting Insulin Analogues

Predicting sight-threatening diabetic retinopathy using the combination of serum cystatin C and indirect bilirubin

The Rise and Evolution of Cancer Mechanobiology: A Bibliometric Trajectory of Three Decades of Research

In-Process Analytics for IVT mRNA Manufacturing: From Process Understanding to Advanced Process Control

An Integrative Pharmacovigilance, Network Toxicology and Molecular Docking Study on Drug-Induced Cheilitis

Selection of Beneficial Fungi for Plants with the Potential to Metabolize Lunar and Martian Regolith

Towards LLM-Aware Software Effort Estimation: A Conceptual Framework

Circulating fatty acids and risk of Gastrointestinal cancer in the UK Biobank

Cancer cells metastasize in several types of cancer via two distinct routes, probably based on mechanical signals

Linagliptin loaded chitosan nanoparticles for the efficient therapy of renal fibrosis

Knowledge, Attitudes, and Practices Regarding Nasopharyngeal Carcinoma among Young Adults and Students in Southern China: A Cross-Sectional Study

Developing Ecological Compensation Standards for WaterResources: Evidence from the Enshi Section of the Qingjiang River Basin