Keloids | List of Frontiers open access articles

Review

Published on 07 Aug 2019

Understanding Keloid Pathobiology From a Quasi-Neoplastic Perspective: Less of a Scar and More of a Chronic Inflammatory Disease With Cancer-Like Tendencies

in Inflammation

Silvian Tan
Nonhlanhla Khumalo
Ardeshir Bayat

Frontiers in Immunology

doi 10.3389/fimmu.2019.01810

35,889 views
170 citations

Review

Published on 26 May 2020

The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models

in Cell Growth and Division

Grace C. Limandjaja
Frank B. Niessen
Rik J. Scheper
Susan Gibbs

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2020.00360

57,393 views
304 citations

Original Research

Published on 03 Aug 2022

Single-cell RNA sequencing reveals distinct immunology profiles in human keloid

in Systems Immunology

Cheng Feng
Mengjie Shan
Yijun Xia
Zhi Zheng
Kai He
Yingxin Wei
Kexin Song
Tian Meng
Hao Liu
Yan Hao

Frontiers in Immunology

doi 10.3389/fimmu.2022.940645

25,299 views
65 citations

Case Report

Published on 27 May 2024

Successful treatment of Giant keloid on the right toes using trepanation combined with superficial radiotherapy (SRT-100): a case report with literature review

in Dermatology

Ying-hua Song
Hui-min Zhu
Dan Chen
Zi-lu Qu
Liang Zhang
Li Wei

Frontiers in Medicine

doi 10.3389/fmed.2024.1369953

3,824 views
3 citations

Original Research

Published on 04 Apr 2023

Impact of internal mammary artery perforator propeller flaps combined with radiotherapy in the treatment of large chest keloids: Our experience

in Reconstructive and Plastic Surgery

Jianfang Zhao
Kun Xie
Shangbin Qin
Rui He
Shan Jiang
Xin Qi
Bing Wen

Frontiers in Surgery

doi 10.3389/fsurg.2023.1136496

2,872 views
2 citations

Review

Published on 15 Aug 2022

Emerging roles of long non-coding RNAs in keloids

in Epigenomics and Epigenetics

Xin Yu
Xueqing Zhu
Hongjun Xu
Linfeng Li

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2022.963524

3,653 views
10 citations

Clinical Trial

Published on 01 Mar 2024

Myofibroblasts reside in the middle dermis of the keloids but do not predict the response to injection therapies: a double-blinded, randomized, controlled trial

in Dermatology

Tuomas Komulainen
Patrik Daymond
Kristiina E. Hietanen
Ilkka S. Kaartinen
Tero A. H. Järvinen

Frontiers in Medicine

doi 10.3389/fmed.2024.1293028

3,721 views
3 citations

Original Research

Published on 29 Sep 2022

Landscape of circulating metabolic fingerprinting for keloid

in Inflammation

Yu Hu
Xuyue Zhou
Lihao Chen
Rong Li
Shuang Jin
Lingxi Liu
Mei Ju
Chao Luan
Hongying Chen
Ziwei Wang

Frontiers in Immunology

doi 10.3389/fimmu.2022.1005366

3,595 views
7 citations

Original Research

Published on 19 May 2023

Deciphering the single-cell transcriptome network in keloids with intra-lesional injection of triamcinolone acetonide combined with 5-fluorouracil

in Cancer Immunity and Immunotherapy

Yijun Xia
Youbin Wang
Yan Hao
Mengjie Shan
Hao Liu
Zhengyun Liang
Xinwen Kuang

Frontiers in Immunology

doi 10.3389/fimmu.2023.1106289

8,039 views
9 citations

Review

Published on 28 Jan 2026

Therapeutic value of mesenchymal stem cell-derived extracellular vesicles in hypertrophic and keloid scars: a systematic review and meta-analysis

in Stem Cell Research

Tianhui Zhai
Wanqi Tang
Pengchao Liu
Yakun Liang
Zhihong Ma
Leiqiang Fan

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2026.1739106

857 views

Mini Review

Published on 25 Nov 2024

Roles of MMP-2 and MMP-9 and their associated molecules in the pathogenesis of keloids: a comprehensive review

in Integrative and Regenerative Pharmacology

Yajie Wang
Liying Zheng
Lai Zhang
Yuncheng Tai
Xuesong Lin
Zhencheng Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1444653

7,166 views
16 citations

Original Research

Published on 10 Jan 2025

The efficacy of sequentially comprehensive treatment based on surgery in the treatment of keloids: a retrospective study

in Dermatology

Kun Yang
Mengdong Shi
Shubo Li
Jianning Sun
Ran Huo
Cong Fu

Frontiers in Medicine

doi 10.3389/fmed.2024.1492407

2,916 views
2 citations

Original Research

Published on 23 Aug 2022

Activation of the NFκB signaling pathway in IL6+CSF3+ vascular endothelial cells promotes the formation of keloids

in Tissue Engineering and Regenerative Medicine

Delin Liu
Yidi Zhang
Lisha Zhen
Rong Xu
Zhenling Ji
Zheng Ye

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.917726

4,579 views
7 citations

Original Research

Published on 16 Aug 2024

Human adipose mesenchymal stem cell-derived exosomes alleviate fibrosis by restraining ferroptosis in keloids

in Inflammation Pharmacology

Yuan Tian
Meijia Li
Rong Cheng
Xinyue Chen
Zhishan Xu
Jian Yuan
Zhiyong Diao
Lijun Hao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1431846

5,042 views
6 citations

Review

Published on 16 Nov 2023

Progress in the clinical treatment of keloids

in Dermatology

Wenli Qi
Xinyue Xiao
Jing Tong
Nengqiang Guo

Frontiers in Medicine

doi 10.3389/fmed.2023.1284109

16,980 views
19 citations

Review

Published on 05 Sep 2025

Gut microbiota-derived metabolites in keloid and hypertrophic scarring

in Microorganisms in Vertebrate Digestive Systems

Junjie Jin
Zhenlong Zheng

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1644758

4,430 views

Articles

Understanding Keloid Pathobiology From a Quasi-Neoplastic Perspective: Less of a Scar and More of a Chronic Inflammatory Disease With Cancer-Like Tendencies

The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models

Single-cell RNA sequencing reveals distinct immunology profiles in human keloid

Successful treatment of Giant keloid on the right toes using trepanation combined with superficial radiotherapy (SRT-100): a case report with literature review

Impact of internal mammary artery perforator propeller flaps combined with radiotherapy in the treatment of large chest keloids: Our experience

Emerging roles of long non-coding RNAs in keloids

Myofibroblasts reside in the middle dermis of the keloids but do not predict the response to injection therapies: a double-blinded, randomized, controlled trial

Landscape of circulating metabolic fingerprinting for keloid

Deciphering the single-cell transcriptome network in keloids with intra-lesional injection of triamcinolone acetonide combined with 5-fluorouracil

Therapeutic value of mesenchymal stem cell-derived extracellular vesicles in hypertrophic and keloid scars: a systematic review and meta-analysis

Roles of MMP-2 and MMP-9 and their associated molecules in the pathogenesis of keloids: a comprehensive review

The efficacy of sequentially comprehensive treatment based on surgery in the treatment of keloids: a retrospective study

Activation of the NFκB signaling pathway in IL6+CSF3+ vascular endothelial cells promotes the formation of keloids

Human adipose mesenchymal stem cell-derived exosomes alleviate fibrosis by restraining ferroptosis in keloids

Progress in the clinical treatment of keloids

Gut microbiota-derived metabolites in keloid and hypertrophic scarring