Large Bone Defects | List of Frontiers open access articles

Original Research

Published on 31 May 2021

Exploring the Mechanism of Total Flavonoids of Drynariae Rhizoma to Improve Large Bone Defects by Network Pharmacology and Experimental Assessment

in Ethnopharmacology

Weipeng Sun
Minying Li
Lei Xie
Zhexing Mai
Yan Zhang
Lieliang Luo
Zijian Yan
Zige Li
Hang Dong
Feng Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.603734

5,353 views
19 citations

Case Report

Published on 29 Apr 2025

Masquelet technique combined with a lantern-mimicking frame system for treatment of a 28-cm infected bone defect: a case report

in Orthopedic Surgery

Ji Qv
Feng Gu
Yanbing Wang
Chuangang Peng
Dankai Wu

Frontiers in Surgery

doi 10.3389/fsurg.2025.1577774

1,695 views

Original Research

Published on 23 Sep 2022

PCL strut-like scaffolds appear superior to gyroid in terms of bone regeneration within a long bone large defect: An in silico study

in Biomechanics

Mahdi Jaber
Patrina S. P. Poh
Georg N. Duda
Sara Checa

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.995266

6,211 views
24 citations

Correction

Published on 23 Jul 2021

Corrigendum: Exploring the Mechanism of Total Flavonoids of Drynariae Rhizoma to Improve Large Bone Defects by Network Pharmacology and Experimental Assessment

in Ethnopharmacology

Weipeng Sun
Minying Li
Lei Xie
Zhexing Mai
Yan Zhang
Lieliang Luo
Zijian Yan
Zige Li
Hang Dong
Feng Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.739503

2,645 views
2 citations

Review

Published on 14 Oct 2021

A Critical Review on the Design, Manufacturing and Assessment of the Bone Scaffold for Large Bone Defects

in Biomaterials

Yi Huo
Yongtao Lu
Lingfei Meng
Jiongyi Wu
Tingxiang Gong
Jia’ao Zou
Sergei Bosiakov
Liangliang Cheng

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.753715

10,620 views
39 citations

Original Research

Published on 28 Feb 2022

Remodeling Effects of the Combination of GGT Scaffolds, Percutaneous Electrical Stimulation, and Acupuncture on Large Bone Defects in Rats

in Bionics and Biomimetics

Chun-Hsu Yao
Bo-Yin Yang
Yi-Chen Ethan Li

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.832808

3,800 views
19 citations

Original Research

Published on 25 Oct 2023

Calcium sulfate-Cu2+ delivery system improves 3D-Printed calcium silicate artificial bone to repair large bone defects

in Biomaterials

Shijie Gao
Jiawen Li
Qingjian Lei
Yan Chen
Huayi Huang
Feifei Yan
Lingfei Xiao
Tie Zhang
Linlong Wang
Renxiong Wei

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2023.1224557

6,022 views
11 citations

Original Research

Published on 09 Oct 2024

Histodynamics of calcium phosphate coating on the osseointegration of medical-grade polycaprolactone β-tricalcium phosphate scaffolds

in Bio-interactions and Bio-compatibility

Flavia Medeiros Savi

Frontiers in Biomaterials Science

doi 10.3389/fbiom.2024.1448902

2,000 views
1 citation

Review

Accepted on 09 Feb 2026

Research Progress on Osseointegration Performance of Porous Structure-Modified Titanium Alloy Implants

in Biomaterials

Xingda Huang
Xi Gong
Aofei Xu
Weiying Zhang
Yi Li
Yunfei Jia
Weizhou Yang
Na Yuan
Yin Yang
Dezhi Wang

Frontiers in Bioengineering and Biotechnology

291 views

Mini Review

Published on 02 Oct 2020

Human Amniotic Mesenchymal Stem Cells Promote Endogenous Bone Regeneration

in Bone Research

Jin Li
Zhixuan Zhou
Jin Wen
Fei Jiang
Yang Xia

Frontiers in Endocrinology

doi 10.3389/fendo.2020.543623

8,615 views
27 citations

Original Research

Published on 11 Dec 2024

Injectable MXene/Ag-HA composite hydrogel for enhanced alveolar bone healing and mechanistic study

in Biomaterials

Jialing Li
Zilu Fan
Zhenju Guan
Jianping Ruan

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1485437

3,532 views
6 citations

Original Research

Published on 03 Sep 2021

Osteogenic Response to Polysaccharide Nanogel Sheets of Human Fibroblasts After Conversion Into Functional Osteoblasts by Direct Phenotypic Cell Reprogramming

in Biomaterials

Kei Nakai
Kenta Yamamoto
Tsunao Kishida
Shin-ichiro Kotani
Yoshiki Sato
Satoshi Horiguchi
Hironaka Yamanobe
Tetsuya Adachi
Francesco Boschetto
Elia Marin

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.713932

4,364 views
11 citations

Original Research

Published on 15 Nov 2021

Sustained Release of VEGF to Promote Angiogenesis and Osteointegration of Three-Dimensional Printed Biomimetic Titanium Alloy Implants

in Tissue Engineering and Regenerative Medicine

Youbin Li
Yuzhe Liu
Haotian Bai
Ronghang Li
Jing Shang
Zhengqing Zhu
Liwei Zhu
Chenyi Zhu
Zhenjia Che
Jincheng Wang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.757767

8,354 views
41 citations

Original Research

Published on 23 Oct 2024

Enhancement of a one-step membrane technique for the treatment of large bone defects by pre-seeding the membrane with CD8 lymphocyte depleted bone marrow mononuclear cells in a rat femoral defect model

in Cytokines and Soluble Mediators in Immunity

Marissa Penna-Martinez
Andreas Kammerer
Pia Stützle
Sabatian Fees
Savina Behr
Inna Schaible
Katrin Schröder
René Danilo Verboket
Jonas Neijhoft
Ingo Marzi

Frontiers in Immunology

doi 10.3389/fimmu.2024.1488611

2,465 views
3 citations

Review

Published on 12 Nov 2025

Advances in 3D-Printed scaffolds for bone defect repair: material strategies and synergistic functional performance

in Biomaterials

Xijie Tang
Haijia Xu
Xiangzhong Liu
Yi Yang
Zhanghua Li

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1707406

3,361 views
1 citation

Review

Published on 18 Feb 2022

Traditional Chinese Medicine Compound-Loaded Materials in Bone Regeneration

in Biomaterials

Guiwen Shi
Chaohua Yang
Qing Wang
Song Wang
Gaoju Wang
Rongguang Ao
Dejian Li

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.851561

15,343 views
20 citations

Articles

Exploring the Mechanism of Total Flavonoids of Drynariae Rhizoma to Improve Large Bone Defects by Network Pharmacology and Experimental Assessment

Masquelet technique combined with a lantern-mimicking frame system for treatment of a 28-cm infected bone defect: a case report

PCL strut-like scaffolds appear superior to gyroid in terms of bone regeneration within a long bone large defect: An in silico study

Corrigendum: Exploring the Mechanism of Total Flavonoids of Drynariae Rhizoma to Improve Large Bone Defects by Network Pharmacology and Experimental Assessment

A Critical Review on the Design, Manufacturing and Assessment of the Bone Scaffold for Large Bone Defects

Remodeling Effects of the Combination of GGT Scaffolds, Percutaneous Electrical Stimulation, and Acupuncture on Large Bone Defects in Rats

Calcium sulfate-Cu2+ delivery system improves 3D-Printed calcium silicate artificial bone to repair large bone defects

Histodynamics of calcium phosphate coating on the osseointegration of medical-grade polycaprolactone β-tricalcium phosphate scaffolds

Research Progress on Osseointegration Performance of Porous Structure-Modified Titanium Alloy Implants

Human Amniotic Mesenchymal Stem Cells Promote Endogenous Bone Regeneration

Injectable MXene/Ag-HA composite hydrogel for enhanced alveolar bone healing and mechanistic study

Osteogenic Response to Polysaccharide Nanogel Sheets of Human Fibroblasts After Conversion Into Functional Osteoblasts by Direct Phenotypic Cell Reprogramming

Sustained Release of VEGF to Promote Angiogenesis and Osteointegration of Three-Dimensional Printed Biomimetic Titanium Alloy Implants

Enhancement of a one-step membrane technique for the treatment of large bone defects by pre-seeding the membrane with CD8 lymphocyte depleted bone marrow mononuclear cells in a rat femoral defect model

Advances in 3D-Printed scaffolds for bone defect repair: material strategies and synergistic functional performance

Traditional Chinese Medicine Compound-Loaded Materials in Bone Regeneration