Lead Discovery | List of Frontiers open access articles

Original Research

Published on 04 Feb 2026

PLA-THF-PEG nanoparticles Co-encapsulating AV3 and KH3 for synergistic pancreatic cancer therapy via stromal remodeling and metabolic inhibition

in Experimental Pharmacology and Drug Discovery

Xiaorong Liu
Yuanmin Hu
Jiaqi Yu
Yuzhe Xue
Xuesong He
Fenfen Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1723694

135 views

Review

Published on 04 Feb 2026

Connecting agriculture and renewable energy: insights into microclimatic changes, physiological, biochemical, and yield responses under agrivoltaics: a review

in Controlled Environment Horticulture

Manu Priya
Hilary A. Sandler
Peter Jeranyama
Harsh Nayyar
Giverson Mupambi

Frontiers in Horticulture

doi 10.3389/fhort.2026.1645374

203 views

Editorial

Published on 04 Feb 2026

Editorial: Advancing plant defense: genome editing, RNAi, and synthetic biology for sustainable pest control

in Plant Biotechnology

Sundararajan Balasubramani
Zhiqian Li
Ekambaram Gayathri
Dhandapani Gurusamy
Archana Singh

Frontiers in Plant Science

doi 10.3389/fpls.2026.1785705

416 views

Editorial

Published on 04 Feb 2026

Editorial: Sustainable production of microorganism biomass for industrial fermentation

in Food Microbiology

Emma E. Tymczyszyn
María de los Ángeles Pozo-Bayón
Barbara Bravo-Ferrada
Natalia S. Brizuela

Frontiers in Microbiology

doi 10.3389/fmicb.2026.1783898

251 views

Original Research

Published on 04 Feb 2026

Wuji Pill and Akkermansia muciniphila alleviates intestinal dysfunction and depression-like behavior in irritable bowel syndrome through the microbiota-gut-brain axis

in Microorganisms in Vertebrate Digestive Systems

Mengting Li
Shuiming Xiao
Yanli Wang
Tao Li
Qin Hu
Lijinchuan Dong
Yuxuan Guo
Zhe Shi
Qing Yang
Weiyan Cai

Frontiers in Microbiology

doi 10.3389/fmicb.2026.1739408

201 views

Original Research

Published on 04 Feb 2026

A deep Siamese network framework for precision phage selection in pulmonary infections

in Pulmonary Medicine

Xinghong Wang
Mingpeng Fu
Shigang Lin
Yanshuang Wang
Hua Pei

Frontiers in Medicine

doi 10.3389/fmed.2026.1758028

142 views

Original Research

Published on 04 Feb 2026

Stage-specific metabolic divergence in flavonoid biosynthesis correlates with embryogenic capacity in rubber tree (Hevea brasiliensis)

in Plant Biotechnology

Jia Miao
Xiao-Long Sun
Jin Liu
Ming-Chun Gui
Min Tang
Hai Tian
Wan-Yuan Shi
Ling Li

Frontiers in Plant Science

doi 10.3389/fpls.2026.1766162

307 views

Original Research

Published on 04 Feb 2026

Evaluation of validity, reliability, and readability of AI chatbots for gestational diabetes mellitus: a multi-model comparative study

in Digital Public Health

Xinxin Wang
Shuyan Lin
Hui Liu
Chuanqing Li
Li Zhou
Rongkang Li

Frontiers in Public Health

doi 10.3389/fpubh.2026.1760871

234 views

Systematic Review

Published on 04 Feb 2026

Understanding farmers’ acceptance of digital technologies: a meta-analytic structural equation modeling approach based on the technology acceptance model

in Land, Livelihoods and Food Security

Mori W. Gouroubera
Morrisson Gouthon
Alcade C. Segnon
Faridah Dosso
Quentin Fiacre Togbévi
Ismail Moumouni-Moussa
Robert B. Zougmoré

Frontiers in Sustainable Food Systems

doi 10.3389/fsufs.2026.1723715

175 views

Original Research

Published on 04 Feb 2026

The burden of low back pain and predictions in Asia–Pacific region, 1990–2021: a comparative analysis of China, Japan, Thailand, and Pakistan

in Rheumatology

Chaoshun Zheng
Haojia Huang
Longsheng Zhang
Yanzhen Wang
Jiabin Li
Yueyue Guo
Xuhui He

Frontiers in Medicine

doi 10.3389/fmed.2026.1693067

165 views

Study Protocol

Published on 04 Feb 2026

Effect of physiotherapy interventions on attention, hyperactivity, motor and cognitive outcomes in children with attention deficit hyperactivity disorder: a systematic review protocol

in Autism and Other Neurodevelopmental Disorders

Sakshi Desai
Sharath Hullumani
Irshad Qureshi
Rutuja Sawalkar
Aishik Ghosh

Frontiers in Child and Adolescent Psychiatry

doi 10.3389/frcha.2026.1717704

186 views

Original Research

Published on 04 Feb 2026

Association between osteoporosis knowledge and bone health in patients with autoimmune diseases: a cross-sectional study

in Rheumatology

Binbin Tang
Juxian Xian
Wenjing Zhang
Yuexiu Su
Shiao Wang
Ying Deng
Jingli Tian
Yucheng Li
Yuyue Chen
Qing Chen

Frontiers in Medicine

doi 10.3389/fmed.2026.1741970

110 views

Original Research

Published on 04 Feb 2026

Development and validation of a reading comprehension and fluency screening assessment tool for children aged 7–10: implications for audiological rehabilitation

in Educational Psychology

Bahtiyar Çelikgün
Ferda Akdaş
Büşra Nur Eser
Recep Minga
Gül Ölçek
Cansu Gücüyener
Sude Edman

Frontiers in Psychology

doi 10.3389/fpsyg.2026.1759333

108 views

Original Research

Published on 04 Feb 2026

“You don’t treat your skinny patients like this”: a qualitative study of fertility care experiences among women with larger bodies and infertility

in Access and Barriers to Reproductive Health Services

Vanessa Elliott
Kaitlyn Plummer
Daphna Stroumsa
Ashley Hesson
Erica E. Marsh
Samantha B. Schon

Frontiers in Reproductive Health

doi 10.3389/frph.2026.1730572

135 views

Original Research

Published on 04 Feb 2026

Multicenter real-world data on immunotherapy for R/M HNSCC from China: comprehensive analysis of efficacy and survival differences across diverse clinical backgrounds, and identification of predictive peripheral blood biomarkers

in Cancer Immunity and Immunotherapy

Feifan Sun
Shasha Pu
Bingxin Hou
Jingyi Liu
Changhao Liu
Jian Zang
Haichuan Su
Zhongwei Wang
Xuejiao Song
Siyu Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1720838

156 views

Original Research

Published on 04 Feb 2026

Problematic internet use and its relationship with motor proficiency among adolescents participating in extracurricular sports (a comparative study of Indonesia and Latvia)

in Mental Health and Wellbeing in Education

Rizky Nurulfa
Aija Klavina

Frontiers in Education

doi 10.3389/feduc.2026.1755129

512 views

Articles

PLA-THF-PEG nanoparticles Co-encapsulating AV3 and KH3 for synergistic pancreatic cancer therapy via stromal remodeling and metabolic inhibition

Connecting agriculture and renewable energy: insights into microclimatic changes, physiological, biochemical, and yield responses under agrivoltaics: a review

Editorial: Advancing plant defense: genome editing, RNAi, and synthetic biology for sustainable pest control

Editorial: Sustainable production of microorganism biomass for industrial fermentation

Wuji Pill and Akkermansia muciniphila alleviates intestinal dysfunction and depression-like behavior in irritable bowel syndrome through the microbiota-gut-brain axis

A deep Siamese network framework for precision phage selection in pulmonary infections

Stage-specific metabolic divergence in flavonoid biosynthesis correlates with embryogenic capacity in rubber tree (Hevea brasiliensis)

Evaluation of validity, reliability, and readability of AI chatbots for gestational diabetes mellitus: a multi-model comparative study

Understanding farmers’ acceptance of digital technologies: a meta-analytic structural equation modeling approach based on the technology acceptance model

The burden of low back pain and predictions in Asia–Pacific region, 1990–2021: a comparative analysis of China, Japan, Thailand, and Pakistan

Effect of physiotherapy interventions on attention, hyperactivity, motor and cognitive outcomes in children with attention deficit hyperactivity disorder: a systematic review protocol

Association between osteoporosis knowledge and bone health in patients with autoimmune diseases: a cross-sectional study

Development and validation of a reading comprehension and fluency screening assessment tool for children aged 7–10: implications for audiological rehabilitation

“You don’t treat your skinny patients like this”: a qualitative study of fertility care experiences among women with larger bodies and infertility

Multicenter real-world data on immunotherapy for R/M HNSCC from China: comprehensive analysis of efficacy and survival differences across diverse clinical backgrounds, and identification of predictive peripheral blood biomarkers

Problematic internet use and its relationship with motor proficiency among adolescents participating in extracurricular sports (a comparative study of Indonesia and Latvia)