Lead Discovery | List of Frontiers open access articles

Original Research

Published on 12 Feb 2026

Association between peripheral IFN-γ+ cytotoxic lymphocytes and response to PD-1/PD-L1-based therapy in hepatocellular carcinoma

in Cancer Immunity and Immunotherapy

Hui Lu
Huijuan Fang
Mengqi Ruan
Zhi Duang
Yan Wang
Wenwen Liu
Qin Wang
Qiang Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2026.1738116

Original Research

Published on 12 Feb 2026

The relationship between perceptions of non-formal education and perceptions of 21st-century skills in a religious-collectivist community

in Digital Learning Innovations

Anat Barth
Lee Cahaner
Shneor Ruchwarger

Frontiers in Education

doi 10.3389/feduc.2026.1694349

Systematic Review

Published on 12 Feb 2026

Network meta-analysis and dose–response analysis of exercise on sleep quality and BMI in obese populations

in Public Health and Nutrition

Hongfei Wang
Jiaxin Wang
Lunan Zhao
Yongliang Zhu

Frontiers in Public Health

doi 10.3389/fpubh.2026.1766438

190 views

Original Research

Published on 12 Feb 2026

The gut microbiota composition is shaped by disease activity and individual treatment responses in patients with multiple sclerosis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Veronika Ticha
Stepan Coufal
Zuzana Jiraskova Zakostelska
Tomas Thon
Radka Roubalova
Tomas Hrncir
Miloslav Kverka
Miluse Pavelcova
Pavlina Kleinova
Jana Lizrova Preiningerova

Frontiers in Immunology

doi 10.3389/fimmu.2025.1681342

631 views

Original Research

Published on 12 Feb 2026

Is early thrombectomy of proximal middle cerebral artery occlusion to salvage internal capsule associated with improved clinical outcomes?

in Acute Stroke and Interventional Therapies

Elochukwu Ibekwe
Robert Kassinger
Nicholas Mannix
Jing Peng
Archana Hinduja

Frontiers in Stroke

doi 10.3389/fstro.2026.1751007

110 views

Original Research

Published on 12 Feb 2026

Retrospective insights into probiotic and prebiotic interventions: associations with gut microbiota profiles and nutritional outcomes

in Nutrition and Microbes

Xueli He
Chaoming Chen
Lan Shen
Xiaomei Su
Hao Xie
Mengsi Yang
Wenkang Jiang

Frontiers in Nutrition

doi 10.3389/fnut.2026.1729480

360 views

Original Research

Published on 12 Feb 2026

A refined SMOTE-ENN optimization method based on machine learning for heart rate variability data classification

in Health Informatics

Biao Zhang
Muzi Liang
Yuanlun Zhou
Binbin Ji
Meng Han
Hongyan Li
Xufeng Lang
Yihua Song
Run Gao
Zuojian Zhou

Frontiers in Digital Health

doi 10.3389/fdgth.2026.1749570

198 views

Original Research

Published on 12 Feb 2026

Comparative mediator analysis: establishing links between mathematical thinking and creativity through digital game addiction and violent tendencies across gifted and non-gifted student groups

in Educational Psychology

Zübeyde Er
Ayça Akin
Hayriye Seda Sezgin

Frontiers in Psychology

doi 10.3389/fpsyg.2026.1776528

207 views

Original Research

Published on 12 Feb 2026

Potential key factors? Exploring the predictive role and necessity of emotional intelligence and resilience for pre-service teachers’ critical thinking disposition

in Teacher Education

Yangyintao Zhao
Liangrui Ai

Frontiers in Education

doi 10.3389/feduc.2026.1729435

507 views

Original Research

Published on 12 Feb 2026

Prediction of treatment responsiveness to home-based transcranial photobiomodulation (tPBM) intervention for cognitive decline using fNIRS concurrently recorded during tPBM

in Alzheimer's Disease and Related Dementias

Minyoung Chun
Kyeonggu Lee
Bori Jung
Yunsu Kim
Chaeyeon Yang
JongKwan Choi
Jihyun Cha
Seung-Hwan Lee
Chang-Hwan Im

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1716502

278 views

Original Research

Published on 12 Feb 2026

Resveratrol reduces muscle atrophy and stress pathway activation in a combined disuse-hypoxia-mouse model

in Experimental Pharmacology and Drug Discovery

Aziz Ahmad Khan
Sajid Khan Sadozai
Fawad Ali
Nemat Khan
Rizwan Qaisar

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1753486

229 views

Systematic Review

Published on 12 Feb 2026

Moral decision-making in patients with neurodegenerative diseases: a systematic review

in Cognition

Giorgia Capitani
Daniele Lozzi
Giuseppe Curcio
Simone Migliore

Frontiers in Psychology

doi 10.3389/fpsyg.2026.1745923

347 views

Study Protocol

Published on 12 Feb 2026

Retraining and control therapy: sense of control and catastrophic symptom expectations as targets of a cognitive behavioral treatment for pediatric functional seizures

in Psychological Therapy and Psychosomatics

Caroline Watson
Badhma Valaiyapathi
Jerzy P. Szaflarski
Burel R. Goodin
Aaron D. Fobian

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1610446

230 views

Review

Published on 12 Feb 2026

mRNA vaccines transform personalized lung cancer treatment

in Vaccines and Molecular Therapeutics

Kaiqi Wei
Zitong Wan
Miaomiao Wen
Shaowei Xin
Yinxi Zhou
Jun Wei
Jianfei Zhu
Chengbin Tang
Yanlu Xiong
Tao Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707654

1,110 views

Original Research

Published on 12 Feb 2026

A Treat-to-Target approach in hereditary angioedema: expert consensus from a European committee

in Molecular Innate Immunity

Mauro Cancian
Teresa Caballero
Isabelle Boccon-Gibod
Thomas Buttgereit
Danny Cohn
Efrem Eren
Sorena Kiani-Alikhan
David Launay
Johanna Mandelin
Andrea Zanichelli

Frontiers in Immunology

doi 10.3389/fimmu.2026.1773279

407 views

Original Research

Published on 12 Feb 2026

Training requirements and associated factors for nursing assistants in Jiaxing City, China: a cross-sectional study in healthcare settings

in Healthcare Professions Education

Feng-Yan Pu
Li-Ping Yu
Hui-Ping Shan

Frontiers in Medicine

doi 10.3389/fmed.2026.1710478

121 views

Articles

Association between peripheral IFN-γ+ cytotoxic lymphocytes and response to PD-1/PD-L1-based therapy in hepatocellular carcinoma

The relationship between perceptions of non-formal education and perceptions of 21st-century skills in a religious-collectivist community

Network meta-analysis and dose–response analysis of exercise on sleep quality and BMI in obese populations

The gut microbiota composition is shaped by disease activity and individual treatment responses in patients with multiple sclerosis

Is early thrombectomy of proximal middle cerebral artery occlusion to salvage internal capsule associated with improved clinical outcomes?

Retrospective insights into probiotic and prebiotic interventions: associations with gut microbiota profiles and nutritional outcomes

A refined SMOTE-ENN optimization method based on machine learning for heart rate variability data classification

Comparative mediator analysis: establishing links between mathematical thinking and creativity through digital game addiction and violent tendencies across gifted and non-gifted student groups

Potential key factors? Exploring the predictive role and necessity of emotional intelligence and resilience for pre-service teachers’ critical thinking disposition

Prediction of treatment responsiveness to home-based transcranial photobiomodulation (tPBM) intervention for cognitive decline using fNIRS concurrently recorded during tPBM

Resveratrol reduces muscle atrophy and stress pathway activation in a combined disuse-hypoxia-mouse model

Moral decision-making in patients with neurodegenerative diseases: a systematic review

Retraining and control therapy: sense of control and catastrophic symptom expectations as targets of a cognitive behavioral treatment for pediatric functional seizures

mRNA vaccines transform personalized lung cancer treatment

A Treat-to-Target approach in hereditary angioedema: expert consensus from a European committee

Training requirements and associated factors for nursing assistants in Jiaxing City, China: a cross-sectional study in healthcare settings