Lead Identification Methodologies | List of Frontiers open access articles

Original Research

Published on 03 Mar 2026

A comprehensive evaluation of non-vascular prepontine cistern anatomy influencing trigeminal nerve vulnerability using machine learning-based morphometric analysis

in Precision Medicine

Akçay Övünç Karadaş
Gokalp Tulum
Ömer Karadaş
Muhammet İkbal Işık
Ferhat Cüce
Onur Osman
Zehra Şimşek
Necibe Sare Mert
Niray Baş
Berza Özcan

Frontiers in Medicine

doi 10.3389/fmed.2026.1745815

Case Report

Published on 03 Mar 2026

Targeted and immunotherapy based on tissue of origin in carcinoma of unknown primary: a two-case report and literature review

in Cancer Molecular Targets and Therapeutics

Mei Wang
DongYue Yan
Wen Sun
Jingshan Liang

Frontiers in Oncology

doi 10.3389/fonc.2026.1741467

120 views

Systematic Review

Published on 03 Mar 2026

Association between diabetes mellitus and risk of Alzheimer’s disease: a meta-analysis and systematic review

in Clinical Diabetes

Ju Wu
Jin Li
Xiaolan Qin
Weiping Chen

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1736410

194 views

Review

Published on 03 Mar 2026

Spatiotemporal control of immunogenic cell death: rewiring tumor-immune dialogues for next-generation immunotherapy

in Cancer Immunity and Immunotherapy

Chengbin Li
Lu Zhu
Yubing Wang
Lei Zhao
Xing Lin
Zhixian Sun
Tingxi Yan
Yingduo Wang
Junjie Piao
Aihua Jin

Frontiers in Immunology

doi 10.3389/fimmu.2026.1784935

Systematic Review

Published on 03 Mar 2026

Hyperbaric oxygen therapy modulates immune effector responses and reshapes peripheral immune tolerance: a narrative review

in Immunological Tolerance and Regulation

Shuhao Mei
Boran Dong
Yuling Gao
Jiaqi Zhou
Hailian Yi
Yuyin Han
Wenzhen Zhuo
Mengyan Sun
Meiting Li
Han Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1777972

114 views

Original Research

Published on 03 Mar 2026

The impact of ward noise management and comprehensive nursing intervention on cognitive function, psychological health, and prognosis of post-stroke patients: a randomized controlled trial

in Neurorehabilitation

Yuan Deng
Yanmin Liu
Jie Liu
Yufei Sang
Fang Wang

Frontiers in Neurology

doi 10.3389/fneur.2026.1778278

Original Research

Published on 03 Mar 2026

Outcomes in heart failure patients with third-degree heart block during COVID-19

in Cardiac Rhythmology

Benjamin Kash
Ethan Wahle
Eli Blaney
Saif Zurob
Amjad Kabach
Ali Bin Abdul Jabbar

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1701620

Systematic Review

Published on 03 Mar 2026

How circular is your product? A systematic literature review on the circular product development process

in Circular Economy

Paulo Henrique Paulista
Carlos Henrique Pereira Mello
Jeniffer de Nadae
Patricia Kelli da Silva Oliveira

Frontiers in Sustainability

doi 10.3389/frsus.2025.1721603

589 views

Original Research

Published on 03 Mar 2026

Behavioural withdrawal during an acute stress test as a marker of psychobiological vulnerability in hereditary angioedema

in Inflammation

Luca Ranucci
Francesca Perego
Aida Zulueta
Clara Gino
Azzurra Cesoni Marcelli
Lorenza Chiara Zingale
Laura Adelaide Dalla Vecchia
Beatrice De Maria
Alessandra Gorini

Frontiers in Immunology

doi 10.3389/fimmu.2026.1784326

Original Research

Published on 03 Mar 2026

Incidence, prevalence, and global burden of myocarditis among individuals aged 65 and older from 1990 to 2021 across 204 countries: a critical re-analysis of data from the global burden of disease study

in Cardiovascular Epidemiology and Prevention

Ang Li
Jingyu Tan
Jing Hu
Yongyi Bai

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1611616

Original Research

Published on 03 Mar 2026

Design and application of enhanced extended state observer for improving bus voltage stability during EIS testing of multi-stack proton exchange membrane fuel cells

in Fuel Cells, Electrolyzers and Membrane Reactors

Kai Zhao
Zhihao Song
Shuming Xu
Fuhua Fan
Jian Mei
Chuanyu Sun

Frontiers in Energy Research

doi 10.3389/fenrg.2026.1731457

200 views

Clinical Trial

Published on 03 Mar 2026

Multi-strain probiotic reduces gastrointestinal side effects in women with elevated HOMA-IR index treated with metformin: a 12-week randomised controlled trial

in Clinical Diabetes

Marzena Ratajczak
Agnieszka Bilska
Katarzyna Musialik
Karolina Skonieczna-Żydecka
Igor Łoniewski
Anna Gogojewicz
Joanna Karolkiewicz

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1765741

107 views

Original Research

Published on 03 Mar 2026

Metatranscriptomics reveals the horse gut RNA virome and a viral sharing network with human and domestic animals

in One Health

Can Li
Kaiping Liu
Ni Wei
Shengwei Hu
Xiaoyue Li
Cunyuan Li

Frontiers in Veterinary Science

doi 10.3389/fvets.2026.1755551

120 views

Original Research

Published on 03 Mar 2026

Situational self-assertion in self–other dilemmas among young adults in five cultures: negotiations between self and others

in Human Developmental Psychology

Mika Hirai
Susie D. Lamborn

Frontiers in Psychology

doi 10.3389/fpsyg.2026.1766805

114 views

Original Research

Published on 03 Mar 2026

Phosphoproteomics uncovers a neuroimmune perspective on trigeminal neuralgia: sexually dimorphic regulatory networks linking calcium channels to the complement cascade

in Multiple Sclerosis and Neuroimmunology

Xiaojie Zhai
Xianghong Lin
Linlin Zhang
Yuxuan Ren
He Miao
Mengmeng Miao
Yijun Chen
Yiwei Zhang
Changshun Huang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1676019

105 views

Original Research

Published on 03 Mar 2026

Polysaccharides from Psoralea corylifolia alleviate CTX-induced immunosuppression in mice by modulating gut microbiota- metabolite-immune signaling

in Nutritional Immunology

Zhenhua Yin
Guangyu Hong
Hao Zhang
Juanjuan Zhang
Qingfeng Guo
Kun Li
Li Wang
Lin Chen

Frontiers in Immunology

doi 10.3389/fimmu.2026.1759122

Articles

A comprehensive evaluation of non-vascular prepontine cistern anatomy influencing trigeminal nerve vulnerability using machine learning-based morphometric analysis

Targeted and immunotherapy based on tissue of origin in carcinoma of unknown primary: a two-case report and literature review

Association between diabetes mellitus and risk of Alzheimer’s disease: a meta-analysis and systematic review

Spatiotemporal control of immunogenic cell death: rewiring tumor-immune dialogues for next-generation immunotherapy

Hyperbaric oxygen therapy modulates immune effector responses and reshapes peripheral immune tolerance: a narrative review

The impact of ward noise management and comprehensive nursing intervention on cognitive function, psychological health, and prognosis of post-stroke patients: a randomized controlled trial

Outcomes in heart failure patients with third-degree heart block during COVID-19

How circular is your product? A systematic literature review on the circular product development process

Behavioural withdrawal during an acute stress test as a marker of psychobiological vulnerability in hereditary angioedema

Incidence, prevalence, and global burden of myocarditis among individuals aged 65 and older from 1990 to 2021 across 204 countries: a critical re-analysis of data from the global burden of disease study

Design and application of enhanced extended state observer for improving bus voltage stability during EIS testing of multi-stack proton exchange membrane fuel cells

Multi-strain probiotic reduces gastrointestinal side effects in women with elevated HOMA-IR index treated with metformin: a 12-week randomised controlled trial

Metatranscriptomics reveals the horse gut RNA virome and a viral sharing network with human and domestic animals

Situational self-assertion in self–other dilemmas among young adults in five cultures: negotiations between self and others

Phosphoproteomics uncovers a neuroimmune perspective on trigeminal neuralgia: sexually dimorphic regulatory networks linking calcium channels to the complement cascade

Polysaccharides from Psoralea corylifolia alleviate CTX-induced immunosuppression in mice by modulating gut microbiota- metabolite-immune signaling