Lead Identification Methodologies | List of Frontiers open access articles

Review

Published on 04 Mar 2026

AI-driven pilot platforms and computational pharmaceutics: accelerating innovation in small molecule drug development under industry 4.0 and 5.0 paradigms

in Experimental Pharmacology and Drug Discovery

Kaixin Luo
Yuhan Yang
Sadaruddin Chachar
Chenggong Zhong
Meiqi Chen
Jun Xiong
Lianyi He
Dingying Liu
Shahla Karim Baloch
Ihab Elshoura

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1681040

158 views

Original Research

Published on 04 Mar 2026

Enhanced autosuccession after wildfire in a transitional sub-Mediterranean forest ecosystem: evidence from the Kras Plateau (Slovenia)

in Functional Plant Ecology

Andraž Čarni
Mateja Breg Valjavec
Lucia Čahojová
Aljaž Jakob

Frontiers in Plant Science

doi 10.3389/fpls.2026.1772621

222 views

Original Research

Published on 04 Mar 2026

Association of plasma ceramide with stroke-associated pneumonia in acute ischemic stroke

in Cytokines and Soluble Mediators in Immunity

Hao Li
Mengwen Lu
Xinyi Ye
Xinyan Guo
Tianyu Ma
Zhouao Zhang
Mingjin Yang
Xue Du
Yingying Wang
Xiaoyu Huang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1739949

Original Research

Published on 04 Mar 2026

Association of analgesic pharmacological effect with pain site in pediatric oncology patients

in Pediatric Pain

Flavia Carvalho Marotta
Eduardo Ladeia Leal
Isabelle Alvarenga Oliveira
Thuane Sales Gonçalves
Silmara Rodrigues Machado
Carolina Paula Jesus Kasa
Paulo Caleb Júnior Lima Santos

Frontiers in Pain Research

doi 10.3389/fpain.2026.1685357

121 views

Original Research

Published on 04 Mar 2026

Electroacupuncture alleviates comorbid obesity and depression via the gut-brain axis: orchestrating SCFA-producing bacteria and hippocampal synaptic plasticity

in Microorganisms in Vertebrate Digestive Systems

Yaxin Zhang
Yuxin Pang
Haoyuan Tan
Ronghui Xian
Junquan Liang
Qianyi Wen
Zhongxian Li
Luda Yan
Zeping Xie
Jingjing Liang

Frontiers in Microbiology

doi 10.3389/fmicb.2026.1772788

Original Research

Published on 04 Mar 2026

Composition dependence of ion heating in dayside magnetopause reconnection: MMS observations

in Space Physics

Elizabeth L. M. Hanson
Laura Balboa
Alayna Corona
Cynthia A. Cattell
Evan Tyler
Tai D. Phan
Stephen A. Fuselier
Roman G. Gomez

Frontiers in Astronomy and Space Sciences

doi 10.3389/fspas.2025.1749271

405 views

Original Research

Published on 04 Mar 2026

Cognitive and emotional conflict control among children affected by parental HIV/AIDS in China

in Public Mental Health

Huihui Wang
Juan Liu
Danfeng Wen
Wan Zhao
Xiaoming Li
Junfeng Zhao

Frontiers in Psychiatry

doi 10.3389/fpsyt.2026.1742261

115 views

Study Protocol

Published on 04 Mar 2026

Acupuncture and related therapies for insomnia symptoms in hypertensive patients: protocol for a network meta-analysis of randomized controlled trials

in Sleep Disorders

Ning Sun
Ying-peng Zhi
Ting Feng
Yun-jiao Sheng

Frontiers in Neurology

doi 10.3389/fneur.2026.1730432

Case Report

Published on 04 Mar 2026

Case Report: Rapid recurrence of psoriasiform dermatitis upon sequential anti-PD-1 therapy with pembrolizumab and tislelizumab with 3-year follow-up

in Immunological Memory

Chao-Cheng Chi
Zi-Yun Li
Sui-Qing Cai
Zhuang-Li Tang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1760904

Original Research

Published on 04 Mar 2026

Variation trend of nitrogen and phosphorus in Lake Caohai, Guizhou Province, China, during 2014–2024

in Environmental Water Quality

Shinong Liu
Xu Zhang
Jingcheng Ran
Dan Yang

Frontiers in Water

doi 10.3389/frwa.2026.1763707

152 views

Original Research

Published on 04 Mar 2026

Exploring challenges and agroecological solutions for vegetable production in semi-arid Turkana County, Kenya

in Agroecology and Ecosystem Services

Alex Eeman Aule
Aspasia Werner
Irmgard Jordan
Gudrun B. Keding

Frontiers in Sustainable Food Systems

doi 10.3389/fsufs.2026.1736719

260 views

Original Research

Published on 04 Mar 2026

Dropout rates and factors associated with adherence to opioid agonist treatment among adults with opioid use disorder at Sekou Toure Regional Referral Hospital, Mwanza, Tanzania

in Addictive Disorders

Tusherahma Hussein Tuli
Allen Rweyendera
Greyson Gwahula
Yacinter Vedastus
Raymond Maziku
Peter Chilipweli
Kiyeti A. Hauli

Frontiers in Psychiatry

doi 10.3389/fpsyt.2026.1660196

222 views

Original Research

Published on 04 Mar 2026

Lack of knowledge of thalassemia among non-medical university students in Saudi Arabia: a cross-sectional study

in Public Health Education and Promotion

Noara Alhusseini
Peter M. B. Cahusac
Yara O. Alsouss
Sabri Kemahli

Frontiers in Public Health

doi 10.3389/fpubh.2026.1722773

Review

Published on 04 Mar 2026

The influence of prime characteristics in semantic priming

in Psychology of Language

Ajay Mangat
Alexander Taikh
Christina Gagne
Thomas L Spalding

Frontiers in Psychology

doi 10.3389/fpsyg.2026.1680365

Review

Published on 04 Mar 2026

Emerging pathological mechanisms of Alzheimer’s disease pathogenesis: from neuroimmune interactions to intercellular communication

in Alzheimer's Disease and Related Dementias

Rutong Wang
Yingqi Feng
Ziyu Zhou
Jiajun Jiang
Runze Zhang
Wenhui Zou
Haotian Yang
Wenbo Lv
Shen Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1748418

Original Research

Published on 04 Mar 2026

Study on the effect of community intervention on patients with hypertension in high-normal blood pressure

in Family Medicine and Primary Care

Qingxia Gao
Zhiguang Gao
Qianfeng Yang
Lijun Wang
Lishuang Xu

Frontiers in Medicine

doi 10.3389/fmed.2026.1761106

Articles

AI-driven pilot platforms and computational pharmaceutics: accelerating innovation in small molecule drug development under industry 4.0 and 5.0 paradigms

Enhanced autosuccession after wildfire in a transitional sub-Mediterranean forest ecosystem: evidence from the Kras Plateau (Slovenia)

Association of plasma ceramide with stroke-associated pneumonia in acute ischemic stroke

Association of analgesic pharmacological effect with pain site in pediatric oncology patients

Electroacupuncture alleviates comorbid obesity and depression via the gut-brain axis: orchestrating SCFA-producing bacteria and hippocampal synaptic plasticity

Composition dependence of ion heating in dayside magnetopause reconnection: MMS observations

Cognitive and emotional conflict control among children affected by parental HIV/AIDS in China

Acupuncture and related therapies for insomnia symptoms in hypertensive patients: protocol for a network meta-analysis of randomized controlled trials

Case Report: Rapid recurrence of psoriasiform dermatitis upon sequential anti-PD-1 therapy with pembrolizumab and tislelizumab with 3-year follow-up

Variation trend of nitrogen and phosphorus in Lake Caohai, Guizhou Province, China, during 2014–2024

Exploring challenges and agroecological solutions for vegetable production in semi-arid Turkana County, Kenya

Dropout rates and factors associated with adherence to opioid agonist treatment among adults with opioid use disorder at Sekou Toure Regional Referral Hospital, Mwanza, Tanzania

Lack of knowledge of thalassemia among non-medical university students in Saudi Arabia: a cross-sectional study

The influence of prime characteristics in semantic priming

Emerging pathological mechanisms of Alzheimer’s disease pathogenesis: from neuroimmune interactions to intercellular communication

Study on the effect of community intervention on patients with hypertension in high-normal blood pressure