Leptin Deficiency | List of Frontiers open access articles

Review

Published on 24 Aug 2021

When Leptin Is Not There: A Review of What Nonsyndromic Monogenic Obesity Cases Tell Us and the Benefits of Exogenous Leptin

in Cellular Endocrinology

Kaio Cezar Rodrigues Salum
Jônatas de Mendonça Rolando
Verônica Marques Zembrzuski
João Regis Ivar Carneiro
Cicero Brasileiro Mello
Clarissa Menezes Maya-Monteiro
Patrícia Torres Bozza
Fabiana Barzotto Kohlrausch
Ana Carolina Proença da Fonseca

Frontiers in Endocrinology

doi 10.3389/fendo.2021.722441

11,726 views
28 citations

Original Research

Published on 23 May 2022

Lower Circulating Leptin Levels Are Related to Non-Alcoholic Fatty Liver Disease in Children With Obesity

in Obesity

Stephanie Brandt
Julia von Schnurbein
Christian Denzer
Wolfgang Kratzer
Martin Wabitsch

Frontiers in Endocrinology

doi 10.3389/fendo.2022.881982

3,520 views
6 citations

Original Research

Published on 21 May 2025

A real-world pharmacovigilance assessment and literature review of lymphoma development in lipodystrophy

in Cancer Endocrinology

Rebecca J. Brown
David Araujo-Vilar
Kelly J. Walkovich
Alexandru Barbarosie
David A. Magee
Baris Akinci
Elif A. Oral

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1582715

4,735 views
1 citation

Mini Review

Published on 23 Dec 2024

Exploring the therapeutic potential of precision medicine in rare genetic obesity disorders: a scientific perspective

in Nutrition, Psychology and Brain Health

Tinh-Hai Collet
Valerie Schwitzgebel

Frontiers in Nutrition

doi 10.3389/fnut.2024.1509994

5,024 views
1 citation

Case Report

Published on 18 Nov 2025

Case Report: Metreleptin treatment enables successful pregnancy in a female with congenital generalized lipodystrophy

in Clinical Diabetes

Maria Somali
Emmanouil Korakas
Eirini Pizirtzidou
Zoe A. Efstathiadou
Michail Sapranidis
Zadalla Mouslech

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1715799

1,334 views

Case Report

Published on 28 Jun 2021

Misdiagnosis of Paget’s Disease of Bone in a Congenital Generalized Lipodystrophy Patient: Case Report

in Bone Research

Erika Bastos Lima Freire
Mayara Ponte Madeira
Grayce Ellen da Cruz Paiva Lima
Virginia Oliveira Fernandes
Lindenberg Barbosa Aguiar
João Paulo Uchoa Fontenele
Ana Paula Dias Rangel Montenegro
Thyciara Fontenele Marques
Renan Galvão Ozório
Catarina Brasil d’Alva

Frontiers in Endocrinology

doi 10.3389/fendo.2021.683697

9,722 views
2 citations

Original Research

Published on 01 Dec 2021

The Role of Estrogen Receptor α in Response to Longitudinal Bone Growth in ob/ob Mice

in Bone Research

Lin-Yu Jin
Chen Guo
Shuai Xu
Hai-Ying Liu
Xin-Feng Li

Frontiers in Endocrinology

doi 10.3389/fendo.2021.749449

4,579 views
4 citations

Review

Published on 05 Aug 2015

Chronic Oxytocin Administration as a Treatment Against Impaired Leptin Signaling or Leptin Resistance in Obesity

in Endocrinology of Aging

Jordi Altirriba
Anne-Laure Poher
Françoise Rohner-Jeanrenaud

Frontiers in Endocrinology

doi 10.3389/fendo.2015.00119

12,632 views
55 citations

Mini Review

Published on 04 May 2022

Treatment Options for Lipodystrophy in Children

in Pediatric Endocrinology

Francesca Mainieri
Veronica Maria Tagi
Francesco Chiarelli

Frontiers in Endocrinology

doi 10.3389/fendo.2022.879979

8,050 views
9 citations

Original Research

Published on 27 Nov 2020

Aerobic Exercise Training Exerts Beneficial Effects Upon Oxidative Metabolism and Non-Enzymatic Antioxidant Defense in the Liver of Leptin Deficiency Mice

in Obesity

Matheus Santos de Sousa Fernandes
Lucas de Lucena de Simões e Silva
Márcia Saldanha Kubrusly
Talitta Ricarlly Lopes de Arruda Lima
Cynthia Rodrigues Muller
Anna Laura Viacava Américo
Mariana Pinheiro Fernandes
Bruno Cogliati
José Tadeu Stefano
Claudia Jacques Lagranha

Frontiers in Endocrinology

doi 10.3389/fendo.2020.588502

5,832 views
20 citations

Review

Published on 18 Nov 2021

Lipidized Prolactin-Releasing Peptide as a New Potential Tool to Treat Obesity and Type 2 Diabetes Mellitus: Preclinical Studies in Rodent Models

in Experimental Pharmacology and Drug Discovery

Lucia Mráziková
Barbora Neprašová
Anna Mengr
Andrea Popelová
Veronika Strnadová
Lucie Holá
Blanka Železná
Jaroslav Kuneš
Lenka Maletínská

Frontiers in Pharmacology

doi 10.3389/fphar.2021.779962

6,618 views
14 citations

Original Research

Published on 03 May 2023

Leptin deficiency in CD8+ T cells ameliorates non-segmental vitiligo by reducing interferon-γ and Granzyme B

in T Cell Biology

Meiyu Wu
Lu Wang
Haijing Wu
Ming Yang
Zhenghao He
Yiran Chen
Huiming Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2023.1158883

7,580 views
11 citations

Original Research

Published on 19 Jan 2017

Odor-Induced Neuronal Rhythms in the Olfactory Bulb Are Profoundly Modified in ob/ob Obese Mice

in Integrative Physiology

Yan Chelminski
Christophe Magnan
Serge H. Luquet
Amandine Everard
Nicolas Meunier
Hirac Gurden
Claire Martin

Frontiers in Physiology

doi 10.3389/fphys.2017.00002

5,524 views
20 citations

Original Research

Published on 07 Jun 2019

Diet Control More Intensively Disturbs Gut Microbiota Than Genetic Background in Wild Type and ob/ob Mice

in Systems Microbiology

Jing-Hua Wang
Na Rae Shin
Soo-Kyoung Lim
Ungjin Im
Eun-Ji Song
Young-Do Nam
Hojun Kim

Frontiers in Microbiology

doi 10.3389/fmicb.2019.01292

6,229 views
20 citations

Original Research

Published on 03 May 2019

Combined Effect of Fatty Diet and Cognitive Decline on Brain Metabolism, Food Intake, Body Weight, and Counteraction by Intranasal Insulin Therapy in 3×Tg Mice

in Cellular Neurophysiology

Elena Sanguinetti
Maria Angela Guzzardi
Daniele Panetta
Maria Tripodi
Vincenzo De Sena
Mauro Quaglierini
Silvia Burchielli
Piero A. Salvadori
Patricia Iozzo

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2019.00188

5,976 views
27 citations

Review

Published on 17 May 2019

Clinical Trials Required to Assess Potential Benefits and Side Effects of Treatment of Patients With Anorexia Nervosa With Recombinant Human Leptin

in Eating Behavior

Johannes Hebebrand
Gabriella Milos
Martin Wabitsch
Martin Teufel
Dagmar Führer
Judith Bühlmeier
Lars Libuda
Christine Ludwig
Jochen Antel

Frontiers in Psychology

doi 10.3389/fpsyg.2019.00769

15,228 views
63 citations

Articles

When Leptin Is Not There: A Review of What Nonsyndromic Monogenic Obesity Cases Tell Us and the Benefits of Exogenous Leptin

Lower Circulating Leptin Levels Are Related to Non-Alcoholic Fatty Liver Disease in Children With Obesity

A real-world pharmacovigilance assessment and literature review of lymphoma development in lipodystrophy

Exploring the therapeutic potential of precision medicine in rare genetic obesity disorders: a scientific perspective

Case Report: Metreleptin treatment enables successful pregnancy in a female with congenital generalized lipodystrophy

Misdiagnosis of Paget’s Disease of Bone in a Congenital Generalized Lipodystrophy Patient: Case Report

The Role of Estrogen Receptor α in Response to Longitudinal Bone Growth in ob/ob Mice

Chronic Oxytocin Administration as a Treatment Against Impaired Leptin Signaling or Leptin Resistance in Obesity

Treatment Options for Lipodystrophy in Children

Aerobic Exercise Training Exerts Beneficial Effects Upon Oxidative Metabolism and Non-Enzymatic Antioxidant Defense in the Liver of Leptin Deficiency Mice

Lipidized Prolactin-Releasing Peptide as a New Potential Tool to Treat Obesity and Type 2 Diabetes Mellitus: Preclinical Studies in Rodent Models

Leptin deficiency in CD8+ T cells ameliorates non-segmental vitiligo by reducing interferon-γ and Granzyme B

Odor-Induced Neuronal Rhythms in the Olfactory Bulb Are Profoundly Modified in ob/ob Obese Mice

Diet Control More Intensively Disturbs Gut Microbiota Than Genetic Background in Wild Type and ob/ob Mice

Combined Effect of Fatty Diet and Cognitive Decline on Brain Metabolism, Food Intake, Body Weight, and Counteraction by Intranasal Insulin Therapy in 3×Tg Mice

Clinical Trials Required to Assess Potential Benefits and Side Effects of Treatment of Patients With Anorexia Nervosa With Recombinant Human Leptin