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4 articles related to "Olt1177"

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Articles

Original Research

Published on 01 Nov 2019

OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis

in Multiple Sclerosis and Neuroimmunology

Alba Sánchez-Fernández
Damaris B. Skouras
Charles A. Dinarello
Rubèn López-Vales

Frontiers in Immunology

doi 10.3389/fimmu.2019.02578

18,751 views
133 citations

Original Research

Published on 17 Mar 2021

Dengue Virus Envelope Protein Domain III Induces Nlrp3 Inflammasome-Dependent NETosis-Mediated Inflammation in Mice

in Inflammation

Te-Sheng Lien
Der-Shan Sun
Shih-Che Hung
Wen-Sheng Wu
Hsin-Hou Chang

Frontiers in Immunology

doi 10.3389/fimmu.2021.618577

10,231 views
36 citations

Original Research

Published on 31 Aug 2021

Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression

in Inflammation

Isak W. Tengesdal
Alberto Dinarello
Nicholas E. Powers
Matthew A. Burchill
Leo A. B. Joosten
Carlo Marchetti
Charles A. Dinarello

Frontiers in Immunology

doi 10.3389/fimmu.2021.661323

12,392 views
99 citations

Original Research

Published on 29 Apr 2021

Exposure of Platelets to Dengue Virus and Envelope Protein Domain III Induces Nlrp3 Inflammasome-Dependent Platelet Cell Death and Thrombocytopenia in Mice

in Inflammation

Te-Sheng Lien
Hao Chan
Der-Shan Sun
Jhen-Cheng Wu
You-Yen Lin
Guan-Ling Lin
Hsin-Hou Chang

Frontiers in Immunology

doi 10.3389/fimmu.2021.616394

12,090 views
39 citations