Open Problems | List of Frontiers open access articles

Original Research

Published on 03 Mar 2026

Preclinical activity of SHR-A1921, a novel antibody-drug conjugate targeting trophoblast cell-surface antigen2 (Trop-2) in prostate cancer

in Pharmacology of Anti-Cancer Drugs

Binyu Wang
Qiuya Xu
Shan Peng
Zheng Han
Haifeng Huang
Hongqian Guo
Xuefeng Qiu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1713983

426 views

Original Research

Published on 03 Mar 2026

Simulation-based retrofit design for energy efficiency in detached social housing amid rising CO2 emissions

in Urban Science

Muhammad Azzam Ismail
Afaq Hyder Chohan
Wael Hamdan
Jihad Awad

Frontiers in Built Environment

doi 10.3389/fbuil.2025.1721416

536 views

Review

Published on 03 Mar 2026

Phosphoinositide-dependent kinase 1 (PDK1) in cancer: molecular insights and therapeutic strategies

in Medicinal and Pharmaceutical Chemistry

Shatha Algheribe
Ayat Zagzoog
Mohamed Boudjelal
Imadul Islam

Frontiers in Chemistry

doi 10.3389/fchem.2026.1767926

276 views

Original Research

Published on 03 Mar 2026

Anxiety symptoms as the central node: a network analysis of mental health sequelae in a post-COVID-19 national sample

in Health Psychology

Zhitao Yuan
Xianyang Wang
Mengyuan Yang
Lixin Zhao
Chaoxian Wang
Xiangyu Ren
Lei Ren
Na Ni
Shengjun Wu

Frontiers in Psychology

doi 10.3389/fpsyg.2026.1748284

Original Research

Published on 03 Mar 2026

Multidrug-resistant mammary pathogenic Escherichia coli ST479 isolated from Holstein dairy cows in Jiangsu, China

in Food Microbiology

Kun Wang
Minghui Zhang
Yujie Li
Mingxun Li
Yujia Sun
Zhangping Yang

Frontiers in Microbiology

doi 10.3389/fmicb.2026.1737656

Review

Published on 03 Mar 2026

Explainable hybrid intrusion detection for SCADA/ICS: a review and research agenda

in Networks and Communications

Heinrihs Kristians Skrodelis
Andrejs Romanovs

Frontiers in Computer Science

doi 10.3389/fcomp.2026.1724245

114 views

Original Research

Published on 03 Mar 2026

Effects of depression, anxiety, and stress on reading self-efficacy in Peruvian adolescents

in Psychology in Education

Niel Oswaldo Macedo-Muñoz
Denis Frank Cunza-Aranzábal

Frontiers in Education

doi 10.3389/feduc.2026.1738848

188 views

Original Research

Published on 03 Mar 2026

Serum magnesium is associated with osteoporosis risk in postmenopausal women: a retrospective study and risk-prediction model

in Geriatric Medicine

Dongliang Shi
Xiaoyu Li
Nuonan Men
Bowen Ren
Yunfeng Ma
Lisha Wang
Zhongbo Zhang
Kaiguang He
Xuzhao Du
Jili Wang

Frontiers in Medicine

doi 10.3389/fmed.2026.1770830

106 views

Original Research

Published on 03 Mar 2026

The impact of the TyG index and psychosocial factors on depression in elderly non-diabetic patients with atrial fibrillation

in Aging Psychiatry

Jianning Ma
Fang Zhu
Dongmei Ren
Kena Bao
Weilan Yan
Min Liu
Xiangdong Xu

Frontiers in Psychiatry

doi 10.3389/fpsyt.2026.1746187

Correction

Published on 03 Mar 2026

Correction: Optimizing shoreline suitability models framework: integrating advanced GIS methodologies at Aberdeen Proving Ground, Maryland

in Environmental Informatics and Remote Sensing

Afsheen Sadaf
Julie Bruck

Frontiers in Environmental Science

doi 10.3389/fenvs.2026.1812979

Review

Published on 03 Mar 2026

Integrated strategies in meniscus tissue engineering: from biomaterials to stem cell–driven regeneration

in Tissue Engineering and Regenerative Medicine

Puzhen Song
Hongguang Chen
Hebin Ma
Yuanbo Zhou
Yadong Zhang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1691953

760 views

Original Research

Published on 03 Mar 2026

The mediating role of depressive symptoms in the relationship between obesity-related triglyceride-glucose index and cognitive status among middle-aged and elderly adults: a large cohort study

in Aging Psychiatry

Yuxuan Jiang
Chaojin Luo
Yuting Zou

Frontiers in Psychiatry

doi 10.3389/fpsyt.2026.1772673

193 views

Policy Brief

Published on 03 Mar 2026

Policy options for resolving local revenue leakage through collaborative governance in Keerom Regency, Indonesia

in Comparative Governance

Muhamad Efendi Jaya
Akbar Silo
Julius Ary Mollet
Yusuf Gabriel Maniagasi
Usman Idris

Frontiers in Political Science

doi 10.3389/fpos.2026.1739763

Editorial

Published on 03 Mar 2026

Editorial: COVID and psychotropics 2024: lessons learnt and future directions for research

in Psychopharmacology

Patricia Di Ciano
Soumitra Das
Paz Toren
Norbert Scherbaum

Frontiers in Psychiatry

doi 10.3389/fpsyt.2026.1800334

Original Research

Published on 03 Mar 2026

Long-term effects of rootstock and tree density on the economic profitability of ‘Delicious’ apple orchards in the Northeastern U.S

in Crop and Product Physiology

Luis Gonzalez Nieto
Stephen A. Hoying
Gemma Reig
Jaume Lordan
Poliana Francescatto
Michael J. Fargione
Gennaro Fazio
Terence L. Robinson

Frontiers in Plant Science

doi 10.3389/fpls.2026.1762635

Original Research

Published on 03 Mar 2026

Structural configuration and its controls on shale oil accumulation of the Wulalike formation at southern section of western margin, Ordos Basin

in Economic Geology

Jiayi Wei
Junfeng Ren
Xianghui Jing
Puyu Liu

Frontiers in Earth Science

doi 10.3389/feart.2026.1774568

236 views

Articles

Preclinical activity of SHR-A1921, a novel antibody-drug conjugate targeting trophoblast cell-surface antigen2 (Trop-2) in prostate cancer

Simulation-based retrofit design for energy efficiency in detached social housing amid rising CO2 emissions

Phosphoinositide-dependent kinase 1 (PDK1) in cancer: molecular insights and therapeutic strategies

Anxiety symptoms as the central node: a network analysis of mental health sequelae in a post-COVID-19 national sample

Multidrug-resistant mammary pathogenic Escherichia coli ST479 isolated from Holstein dairy cows in Jiangsu, China

Explainable hybrid intrusion detection for SCADA/ICS: a review and research agenda

Effects of depression, anxiety, and stress on reading self-efficacy in Peruvian adolescents

Serum magnesium is associated with osteoporosis risk in postmenopausal women: a retrospective study and risk-prediction model

The impact of the TyG index and psychosocial factors on depression in elderly non-diabetic patients with atrial fibrillation

Correction: Optimizing shoreline suitability models framework: integrating advanced GIS methodologies at Aberdeen Proving Ground, Maryland

Integrated strategies in meniscus tissue engineering: from biomaterials to stem cell–driven regeneration

The mediating role of depressive symptoms in the relationship between obesity-related triglyceride-glucose index and cognitive status among middle-aged and elderly adults: a large cohort study

Policy options for resolving local revenue leakage through collaborative governance in Keerom Regency, Indonesia

Editorial: COVID and psychotropics 2024: lessons learnt and future directions for research

Long-term effects of rootstock and tree density on the economic profitability of ‘Delicious’ apple orchards in the Northeastern U.S

Structural configuration and its controls on shale oil accumulation of the Wulalike formation at southern section of western margin, Ordos Basin