Optimization Based Approach | List of Frontiers open access articles

Original Research

Published on 04 Mar 2026

Pharmacological inhibition of USP18 improves antibacterial responses and the intracellular control of Mycobacterium tuberculosis in macrophages

in Microbial Immunology

Qiao Zhang
Zhen Gong
Robert Schnell
Yi Zhong
Paul P. Geurink
Volker M. Lauschke
Jianping Xie
Stefano Gastaldello
Martin E. Rottenberg

Frontiers in Immunology

doi 10.3389/fimmu.2026.1739628

Original Research

Published on 04 Mar 2026

Visually grounded emotion regulation via diffusion models and user-driven reappraisal

in Medicine and Public Health

Edoardo Pinzuti
Oliver Tüscher
André Ferreira Castro

Frontiers in Artificial Intelligence

doi 10.3389/frai.2026.1691445

228 views

Brief Research Report

Published on 04 Mar 2026

Cervicomedullary motor evoked responses in individuals with severe chronic hemiparesis post-stroke: a feasibility study

in Stroke

Carley L. P. Butler
Aditya Dutt
Carolee J. Winstein
Monica A. Perez
Mary Ellen Stoykov

Frontiers in Neurology

doi 10.3389/fneur.2026.1722620

216 views

Review

Published on 04 Mar 2026

Critical role of reproductive tract microbiota and derived metabolites in inflammation, tumor immunity, and tumorigenesis of gynecological cancers: a narrative review

in Microbial Immunology

Hong Chen
Ge Lou
Fanling Meng
Yang Zhang
Hongying Kuang
Dongxia Yang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1734792

109 views

Original Research

Published on 04 Mar 2026

Analysis of the current status of research on perianal lesions associated with Crohn's disease: a bibliometric and visualization analysis

in Colorectal and Proctological Surgery

Pengfei Zhou
Jingen Lu
Yi Fu
Xi Huang
Yibo Yao
Yanting Sun
Jiawen Wang

Frontiers in Surgery

doi 10.3389/fsurg.2026.1624488

177 views

Review

Published on 04 Mar 2026

AI-driven pilot platforms and computational pharmaceutics: accelerating innovation in small molecule drug development under industry 4.0 and 5.0 paradigms

in Experimental Pharmacology and Drug Discovery

Kaixin Luo
Yuhan Yang
Sadaruddin Chachar
Chenggong Zhong
Meiqi Chen
Jun Xiong
Lianyi He
Dingying Liu
Shahla Karim Baloch
Ihab Elshoura

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1681040

158 views

Original Research

Published on 04 Mar 2026

Enhanced autosuccession after wildfire in a transitional sub-Mediterranean forest ecosystem: evidence from the Kras Plateau (Slovenia)

in Functional Plant Ecology

Andraž Čarni
Mateja Breg Valjavec
Lucia Čahojová
Aljaž Jakob

Frontiers in Plant Science

doi 10.3389/fpls.2026.1772621

222 views

Original Research

Published on 04 Mar 2026

Association of plasma ceramide with stroke-associated pneumonia in acute ischemic stroke

in Cytokines and Soluble Mediators in Immunity

Hao Li
Mengwen Lu
Xinyi Ye
Xinyan Guo
Tianyu Ma
Zhouao Zhang
Mingjin Yang
Xue Du
Yingying Wang
Xiaoyu Huang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1739949

Original Research

Published on 04 Mar 2026

Association of analgesic pharmacological effect with pain site in pediatric oncology patients

in Pediatric Pain

Flavia Carvalho Marotta
Eduardo Ladeia Leal
Isabelle Alvarenga Oliveira
Thuane Sales Gonçalves
Silmara Rodrigues Machado
Carolina Paula Jesus Kasa
Paulo Caleb Júnior Lima Santos

Frontiers in Pain Research

doi 10.3389/fpain.2026.1685357

121 views

Original Research

Published on 04 Mar 2026

Electroacupuncture alleviates comorbid obesity and depression via the gut-brain axis: orchestrating SCFA-producing bacteria and hippocampal synaptic plasticity

in Microorganisms in Vertebrate Digestive Systems

Yaxin Zhang
Yuxin Pang
Haoyuan Tan
Ronghui Xian
Junquan Liang
Qianyi Wen
Zhongxian Li
Luda Yan
Zeping Xie
Jingjing Liang

Frontiers in Microbiology

doi 10.3389/fmicb.2026.1772788

Original Research

Published on 04 Mar 2026

Composition dependence of ion heating in dayside magnetopause reconnection: MMS observations

in Space Physics

Elizabeth L. M. Hanson
Laura Balboa
Alayna Corona
Cynthia A. Cattell
Evan Tyler
Tai D. Phan
Stephen A. Fuselier
Roman G. Gomez

Frontiers in Astronomy and Space Sciences

doi 10.3389/fspas.2025.1749271

405 views

Original Research

Published on 04 Mar 2026

Cognitive and emotional conflict control among children affected by parental HIV/AIDS in China

in Public Mental Health

Huihui Wang
Juan Liu
Danfeng Wen
Wan Zhao
Xiaoming Li
Junfeng Zhao

Frontiers in Psychiatry

doi 10.3389/fpsyt.2026.1742261

115 views

Study Protocol

Published on 04 Mar 2026

Acupuncture and related therapies for insomnia symptoms in hypertensive patients: protocol for a network meta-analysis of randomized controlled trials

in Sleep Disorders

Ning Sun
Ying-peng Zhi
Ting Feng
Yun-jiao Sheng

Frontiers in Neurology

doi 10.3389/fneur.2026.1730432

Case Report

Published on 04 Mar 2026

Case Report: Rapid recurrence of psoriasiform dermatitis upon sequential anti-PD-1 therapy with pembrolizumab and tislelizumab with 3-year follow-up

in Immunological Memory

Chao-Cheng Chi
Zi-Yun Li
Sui-Qing Cai
Zhuang-Li Tang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1760904

Original Research

Published on 04 Mar 2026

Variation trend of nitrogen and phosphorus in Lake Caohai, Guizhou Province, China, during 2014–2024

in Environmental Water Quality

Shinong Liu
Xu Zhang
Jingcheng Ran
Dan Yang

Frontiers in Water

doi 10.3389/frwa.2026.1763707

152 views

Original Research

Published on 04 Mar 2026

Exploring challenges and agroecological solutions for vegetable production in semi-arid Turkana County, Kenya

in Agroecology and Ecosystem Services

Alex Eeman Aule
Aspasia Werner
Irmgard Jordan
Gudrun B. Keding

Frontiers in Sustainable Food Systems

doi 10.3389/fsufs.2026.1736719

260 views

Articles

Pharmacological inhibition of USP18 improves antibacterial responses and the intracellular control of Mycobacterium tuberculosis in macrophages

Visually grounded emotion regulation via diffusion models and user-driven reappraisal

Cervicomedullary motor evoked responses in individuals with severe chronic hemiparesis post-stroke: a feasibility study

Critical role of reproductive tract microbiota and derived metabolites in inflammation, tumor immunity, and tumorigenesis of gynecological cancers: a narrative review

Analysis of the current status of research on perianal lesions associated with Crohn's disease: a bibliometric and visualization analysis

AI-driven pilot platforms and computational pharmaceutics: accelerating innovation in small molecule drug development under industry 4.0 and 5.0 paradigms

Enhanced autosuccession after wildfire in a transitional sub-Mediterranean forest ecosystem: evidence from the Kras Plateau (Slovenia)

Association of plasma ceramide with stroke-associated pneumonia in acute ischemic stroke

Association of analgesic pharmacological effect with pain site in pediatric oncology patients

Electroacupuncture alleviates comorbid obesity and depression via the gut-brain axis: orchestrating SCFA-producing bacteria and hippocampal synaptic plasticity

Composition dependence of ion heating in dayside magnetopause reconnection: MMS observations

Cognitive and emotional conflict control among children affected by parental HIV/AIDS in China

Acupuncture and related therapies for insomnia symptoms in hypertensive patients: protocol for a network meta-analysis of randomized controlled trials

Case Report: Rapid recurrence of psoriasiform dermatitis upon sequential anti-PD-1 therapy with pembrolizumab and tislelizumab with 3-year follow-up

Variation trend of nitrogen and phosphorus in Lake Caohai, Guizhou Province, China, during 2014–2024

Exploring challenges and agroecological solutions for vegetable production in semi-arid Turkana County, Kenya