P53 Independent | List of Frontiers open access articles

Original Research

Published on 08 Apr 2025

MDM2 inhibitor induces apoptosis in colon cancer cells through activation of the CHOP-DR5 pathway, independent of p53 phenotype

in Pharmacology of Anti-Cancer Drugs

Manman Lu
Yingli Ren
Sijia Feng
Shenggen Wang
Weiyue Xia
Baoru Gu
Yuhou Shen
Aimin Yue
Na Li
Yongxi Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1508421

3,085 views

Original Research

Published on 23 Dec 2024

Small-molecule MMRi36 induces apoptosis in p53-mutant lymphomas by targeting MDM2/MDM4/XIAP for degradation

in Cancer Molecular Targets and Therapeutics

Rati Lama
Wenjie Wu
Cory K. Mavis
Federico M. Ruiz
Javier Querol-García
Diana Martin
Sherry R. Chemler
Dhyan Chandra
David W. Goodrich
Francisco J. Hernandez-Ilizaliturri

Frontiers in Oncology

doi 10.3389/fonc.2024.1462231

2,557 views
2 citations

Review

Published on 17 Jun 2013

Mechanisms of Caffeine-Induced Inhibition of UVB Carcinogenesis

in Cancer Molecular Targets and Therapeutics

Allan H Conney
Yao-Ping Lu
You-Rong Lou
Masaoki Kawasumi
Paul Nghiem

Frontiers in Oncology

doi 10.3389/fonc.2013.00144

40,434 views
39 citations

Original Research

Published on 19 Feb 2025

Dual inhibitor of MDM2 and NFAT1 for experimental therapy of breast cancer: in vitro and in vivo anticancer activities and newly discovered effects on cancer metabolic pathways

in Pharmacology of Anti-Cancer Drugs

Wei Wang
Marlene Aguilar
Sayantap Datta
Abigail Alley
Meheret Tadesse
Xinshi Wang
Xia Gao
Ruiwen Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531667

3,391 views
1 citation

Original Research

Published on 02 Oct 2024

Dehydroepiandrosterone suppresses human colorectal cancer progression through ER stress-mediated autophagy and apoptosis in a p53-independent manner

in Pharmacology of Anti-Cancer Drugs

Thi-Huong Nguyen
Huey-Jiun Ko
Po-Yu Tsai
Tai-Shan Cheng
Thu-Ha Tran
Ly Hien Doan
Michael Hsiao
Peter Mu-Hsin Chang
Hsiao-Sheng Liu
Yi-Ren Hong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1464647

3,520 views
4 citations

Original Research

Published on 06 Oct 2021

p53-Independent Effects of Set7/9 Lysine Methyltransferase on Metabolism of Non-Small Cell Lung Cancer Cells

in Cancer Metabolism

Alexandra Daks
Oleg Shuvalov
Olga Fedorova
Alexey Petukhov
Larissa Lezina
Arsenia Zharova
Ekaterina Baidyuk
Alexander Khudiakov
Nickolai A. Barlev

Frontiers in Oncology

doi 10.3389/fonc.2021.706668

5,939 views
13 citations

Perspective

Published on 22 Jul 2014

ARF: a versatile DNA damage response ally at the crossroads of development and tumorigenesis

in Cancer Genetics

Athanassios Kotsinas
Panagiota Papanagnou
Konstantinos Evangelou
George C. Trigas
Vassiliki Kostourou
Paul Townsend
Vassilis G. Gorgoulis

Frontiers in Genetics

doi 10.3389/fgene.2014.00236

7,057 views
14 citations

Brief Research Report

Published on 03 Dec 2020

Protective Effects of p53 Regulatory Agents Against High-LET Radiation-Induced Injury in Mice

in Radiation and Health

Akinori Morita
Bing Wang
Kaoru Tanaka
Takanori Katsube
Masahiro Murakami
Takashi Shimokawa
Yuichi Nishiyama
Shintaro Ochi
Hidetoshi Satoh
Mitsuru Nenoi

Frontiers in Public Health

doi 10.3389/fpubh.2020.601124

4,085 views
8 citations

Original Research

Published on 27 Mar 2025

Comprehensive pan-cancer analysis indicates key gene of p53-independent apoptosis is a novel biomarker for clinical application and chemotherapy in colorectal cancer

in Cancer Immunity and Immunotherapy

Jianing Yan
Jingzhi Wang
Min Miao
Yongfu Shao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1571137

4,125 views

Original Research

Published on 23 Dec 2020

Reciprocal Induction of MDM2 and MYCN in Neural and Neuroendocrine Cancers

in Molecular and Cellular Oncology

Hung N. Tran
Hardeep P. Singh
Wenxuan Guo
Linda Cambier
Luke Riggan
Gregory M. Shackleford
Matthew E. Thornton
Brendan H. Grubbs
Anat Erdreich-Epstein
Dong-Lai Qi

Frontiers in Oncology

doi 10.3389/fonc.2020.563156

4,870 views
14 citations

Review

Published on 13 May 2013

Tumor Protein 53-Induced Nuclear Protein 1 Enhances p53 Function and Represses Tumorigenesis

in Cancer Genetics

Jeyran Shahbazi
Richard Lock
Tao Liu

Frontiers in Genetics

doi 10.3389/fgene.2013.00080

17,274 views
96 citations

Original Research

Published on 03 Jan 2022

Dihydroartemisinin-Transferrin Adducts Enhance TRAIL-Induced Apoptosis in Triple-Negative Breast Cancer in a P53-Independent and ROS-Dependent Manner

in Pharmacology of Anti-Cancer Drugs

Xinyu Zhou
Abel Soto-Gamez
Fleur Nijdam
Rita Setroikromo
Wim J. Quax

Frontiers in Oncology

doi 10.3389/fonc.2021.789336

6,254 views
16 citations

Review

Published on 28 Jan 2022

It’s Getting Complicated—A Fresh Look at p53-MDM2-ARF Triangle in Tumorigenesis and Cancer Therapy

in Molecular and Cellular Oncology

Che-Pei Kung
Jason D. Weber

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2022.818744

26,562 views
62 citations

Original Research

Published on 02 Apr 2025

Potentiating doxorubicin activity through BCL-2 inhibition in p53 wild-type and mutated triple-negative breast cancer

in Breast Cancer

Anna R. Schreiber
Stephen G. Smoots
Marilyn M. Jackson
Stacey M. Bagby
Evan D. Dus
Adrian T. A. Dominguez
Cameron A. Binns
Todd M. Pitts
Jennifer R. Diamond

Frontiers in Oncology

doi 10.3389/fonc.2025.1549282

3,401 views
4 citations

Review

Published on 16 Feb 2026

Nucleolus as a cornerstone linking proliferation and metabolism to cellular responses to stress: involvement of transcription factors MYC and p53

in Cellular Biochemistry

Аnastasiia Moraleva
Nadezhda Antipova
Pankrat Pavlov
Kira Dobrochaeva
Yury Rubtsov

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1749992

407 views

Original Research

Published on 30 Nov 2017

Generation and Functional In Vitro Analysis of Semliki Forest Virus Vectors Encoding TNF-α and IFN-γ

in Cancer Immunity and Immunotherapy

Baiba Kurena
Elisabeth Müller
Panagiotis F. Christopoulos
Ingvild Bjellmo Johnsen
Branislava Stankovic
Inger Øynebråten
Alexandre Corthay
Anna Zajakina

Frontiers in Immunology

doi 10.3389/fimmu.2017.01667

9,559 views
19 citations

Articles

MDM2 inhibitor induces apoptosis in colon cancer cells through activation of the CHOP-DR5 pathway, independent of p53 phenotype

Small-molecule MMRi36 induces apoptosis in p53-mutant lymphomas by targeting MDM2/MDM4/XIAP for degradation

Mechanisms of Caffeine-Induced Inhibition of UVB Carcinogenesis

Dual inhibitor of MDM2 and NFAT1 for experimental therapy of breast cancer: in vitro and in vivo anticancer activities and newly discovered effects on cancer metabolic pathways

Dehydroepiandrosterone suppresses human colorectal cancer progression through ER stress-mediated autophagy and apoptosis in a p53-independent manner

p53-Independent Effects of Set7/9 Lysine Methyltransferase on Metabolism of Non-Small Cell Lung Cancer Cells

ARF: a versatile DNA damage response ally at the crossroads of development and tumorigenesis

Protective Effects of p53 Regulatory Agents Against High-LET Radiation-Induced Injury in Mice

Comprehensive pan-cancer analysis indicates key gene of p53-independent apoptosis is a novel biomarker for clinical application and chemotherapy in colorectal cancer

Reciprocal Induction of MDM2 and MYCN in Neural and Neuroendocrine Cancers

Tumor Protein 53-Induced Nuclear Protein 1 Enhances p53 Function and Represses Tumorigenesis

Dihydroartemisinin-Transferrin Adducts Enhance TRAIL-Induced Apoptosis in Triple-Negative Breast Cancer in a P53-Independent and ROS-Dependent Manner

It’s Getting Complicated—A Fresh Look at p53-MDM2-ARF Triangle in Tumorigenesis and Cancer Therapy

Potentiating doxorubicin activity through BCL-2 inhibition in p53 wild-type and mutated triple-negative breast cancer

Nucleolus as a cornerstone linking proliferation and metabolism to cellular responses to stress: involvement of transcription factors MYC and p53

Generation and Functional In Vitro Analysis of Semliki Forest Virus Vectors Encoding TNF-α and IFN-γ