Paleolithic | List of Frontiers open access articles

Original Research

Published on 03 Oct 2025

DHCLHAM: microbe-drug interaction prediction based on dual-hypergraph contrastive learning framework with hierarchical attention mechanism

in Microbial Symbioses

Hailong Hu
Cong Nie

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1657431

700 views

Original Research

Published on 03 Oct 2025

Exploring chamazulene as a novel therapeutic agent for breast cancer in silico and in vitro: apoptosis induction, cell cycle regulation, and antimetastatic effects

in Pharmacology of Anti-Cancer Drugs

Liang Yao
Wanfu Wang
Bo Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1680615

484 views

Policy and Practice Reviews

Published on 03 Oct 2025

Can international investment agreements protect investments in non-territorial waters?—institutional foundations, jurisdictional analysis, and pathways for improvement

in Marine Pollution

Xingyi Duan
Ziheng Liu

Frontiers in Marine Science

doi 10.3389/fmars.2025.1654756

187 views

Original Research

Published on 03 Oct 2025

The perceived impact of artificial intelligence on academic learning

in AI for Human Learning and Behavior Change

Mariana Dogaru
Olivia Pisică
Cosmin-Ștefan Popa
Andrei-Adrian Răgman
Ilinca-Roxana Tololoi

Frontiers in Artificial Intelligence

doi 10.3389/frai.2025.1611183

858 views

Original Research

Published on 03 Oct 2025

Predictive effect of sustainable dietary and literacy patterns on metabolic syndrome and diabetes risk in Turkish adults: Mediterranean diet, sustainable healthy eating behaviors, and sustainable food literacy perspective

in Family Medicine and Primary Care

Serap İncedal Irgat
Hande Bakırhan
Yunus Emre Bakırhan

Frontiers in Medicine

doi 10.3389/fmed.2025.1693180

217 views

Review

Published on 03 Oct 2025

From bench to bedside: therapeutic potential of natural antioxidants in diabetic neuropathy

in Signaling

Yanxian Zhang
Lili Yao
Yongmei Lyu
Zhuqi Tang
Xiaoyu Liu
Xuchu Duan

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1631678

256 views

Opinion

Published on 03 Oct 2025

Stromal cells unifying the pathology of acute and chronic skeletal muscle injury – clue for novel biomaterials

in Biomaterials

Xianglong Liu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1684310

279 views

Review

Published on 03 Oct 2025

ECM remodeling in hypothyroidism-associated MAFLD: mechanisms, clinical relevance, and therapeutic targets

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Tianzhen Wang
Liyun Duan
Beiying Zhao
Jingbin Zhang
Yongjiang Yu
Jinyue Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639196

154 views

Review

Published on 03 Oct 2025

From crops to clinic: the impact of dual azole use on antifungal resistance in Candida and Candida associated yeasts

in Infectious Agents and Disease

Jessica C. Allison
Edel M. Hyland

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1656723

893 views

Original Research

Published on 03 Oct 2025

Knowledge, attitudes, and practices regarding fertility preservation among women of childbearing age in southern China: a cross-sectional study

in Public Health Education and Promotion

Yan Zhang
Juan An
Fanglan Hua
Yanhong Wei
Fanglian Shu

Frontiers in Public Health

doi 10.3389/fpubh.2025.1612784

135 views

Mini Review

Published on 03 Oct 2025

Neurochemical crossroads: exploring the neurotransmitter network in chronic pain and depression comorbidity

in Pain Mechanisms and Modulators

Min Ma
Yue Zhang
Kunming Tao
Zhijie Lu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1675814

622 views

Review

Published on 03 Oct 2025

Optimization of production strategies for African indigenous trees: a case study of tree growers and sellers of Dovyalis caffra (Kei apple) from Eastern Cape of South Africa

in Food Characterization

M. Mfini
C. P. Laubscher
H. Witbooi

Frontiers in Food Science and Technology

doi 10.3389/frfst.2025.1631026

221 views

Review

Published on 03 Oct 2025

Overcoming resistance to PD-1 and CTLA-4 blockade mechanisms and therapeutic strategies

in Cancer Immunity and Immunotherapy

Xiaodong Wang
Jing He
Gouping Ding
Yixuan Tang
Qianqian Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1688699

134 views

Original Research

Published on 03 Oct 2025

Assessment of smartphone addiction and its relationship with health-promoting lifestyle profile and intuitive eating behavior: a cross-sectional study

in Addictive Disorders

Zhen Ding
Qichuan Pei
Tianle Fang
Lishun Xiao
Dehui Yin
Zhiming Sun

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1682921

265 views

Original Research

Published on 03 Oct 2025

The computational methods and application comparisons for the interaction between surrounding rock and lining in hydraulic tunnels

in Earth and Planetary Materials

Chonglin Yin
Yong Xia
Zhende Zhu
Jinyuan Xie
Bihua Tang
Chun Luo

Frontiers in Earth Science

doi 10.3389/feart.2025.1687458

894 views

Original Research

Published on 03 Oct 2025

A Qualitative Comparative Analysis of cross-sectoral bioresource residue flows from agriculture, forestry, and aquaculture: the crucial role of non-biobased sectors in the development of the circular bioeconomy

in Circular Economy

Pia Piroschka Otte
Anda Adamsone-Fiskovica
Oksana Žabko
Kristiina Kerge
Sandra Šūmane
Svetlana Shvaichenko
Armands Veveris
Diana Mincyte

Frontiers in Sustainability

doi 10.3389/frsus.2025.1490685

6,180 views

Articles

DHCLHAM: microbe-drug interaction prediction based on dual-hypergraph contrastive learning framework with hierarchical attention mechanism

Exploring chamazulene as a novel therapeutic agent for breast cancer in silico and in vitro: apoptosis induction, cell cycle regulation, and antimetastatic effects

Can international investment agreements protect investments in non-territorial waters?—institutional foundations, jurisdictional analysis, and pathways for improvement

The perceived impact of artificial intelligence on academic learning

Predictive effect of sustainable dietary and literacy patterns on metabolic syndrome and diabetes risk in Turkish adults: Mediterranean diet, sustainable healthy eating behaviors, and sustainable food literacy perspective

From bench to bedside: therapeutic potential of natural antioxidants in diabetic neuropathy

Stromal cells unifying the pathology of acute and chronic skeletal muscle injury – clue for novel biomaterials

ECM remodeling in hypothyroidism-associated MAFLD: mechanisms, clinical relevance, and therapeutic targets

From crops to clinic: the impact of dual azole use on antifungal resistance in Candida and Candida associated yeasts

Knowledge, attitudes, and practices regarding fertility preservation among women of childbearing age in southern China: a cross-sectional study

Neurochemical crossroads: exploring the neurotransmitter network in chronic pain and depression comorbidity

Optimization of production strategies for African indigenous trees: a case study of tree growers and sellers of Dovyalis caffra (Kei apple) from Eastern Cape of South Africa

Overcoming resistance to PD-1 and CTLA-4 blockade mechanisms and therapeutic strategies

Assessment of smartphone addiction and its relationship with health-promoting lifestyle profile and intuitive eating behavior: a cross-sectional study

The computational methods and application comparisons for the interaction between surrounding rock and lining in hydraulic tunnels

A Qualitative Comparative Analysis of cross-sectoral bioresource residue flows from agriculture, forestry, and aquaculture: the crucial role of non-biobased sectors in the development of the circular bioeconomy