Patient Derived Ipscs | List of Frontiers open access articles

Mini Review

Published on 13 Aug 2020

Studying Abnormal Chromosomal Diseases Using Patient-Derived Induced Pluripotent Stem Cells

in Cellular Neuropathology

Yohei Hayashi
Miho Takami
Mami Matsuo-Takasaki

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2020.00224

6,648 views
9 citations

Original Research

Published on 01 Apr 2022

Generation and Characterization of iPS Cells Derived from APECED Patients for Gene Correction

in Cellular Endocrinology

Eira Karvonen
Kai J. E. Krohn
Annamari Ranki
Annika Hau

Frontiers in Endocrinology

doi 10.3389/fendo.2022.794327

3,580 views
5 citations

Original Research

Published on 17 Jun 2025

Development of patient-specific iPSC-based epilepsy models and identification of differentially expressed genes for disease mechanisms

in Neurodevelopment

Jianfeng Wu
Siqi Huang
Lihao Chen
Yinghong Yang
Shunhan Zhang
Jiajia Xian
Xiaoyan Ma
Furong Ma
Shaoying Li
Yi Yang

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1582255

2,492 views
1 citation

Original Research

Published on 16 Jan 2024

Disruption of the autism-associated gene SCN2A alters synaptic development and neuronal signaling in patient iPSC-glutamatergic neurons

in Cellular Neuropathology

Chad O. Brown
Jarryll A. Uy
Nadeem Murtaza
Elyse Rosa
Alexandria Alfonso
Biren M. Dave
Savannah Kilpatrick
Annie A. Cheng
Sean H. White
Stephen W. Scherer

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2023.1239069

6,454 views
15 citations

Original Research

Published on 21 Jan 2026

A cross-correction gene therapy approach for CDKL5 deficiency disorder improves the pathological phenotype of CDD patient-derived cortical organoids

in Organoids and Organ-On-A-Chip

Giorgio Medici
Angelica M. Bove
Stefania Trazzi
Francesca Puppo
Manuela Loi
Nicola Mottolese
Giulia Candini
Federica Trebbi
Sandra Sanchez
Alysson R. Muotri

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1744903

901 views

Original Research

Published on 16 Feb 2023

Generation and characterization of NGLY1 patient-derived midbrain organoids

in Molecular and Cellular Pathology

Joshua Abbott
Mitali Tambe
Ivan Pavlinov
Atena Farkhondeh
Ha Nam Nguyen
Miao Xu
Manisha Pradhan
Tate York
Matthew Might
Karsten Baumgärtel

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2023.1039182

5,817 views
16 citations

Review

Published on 10 Nov 2021

Human Induced Pluripotent Stem Cell Models of Frontotemporal Dementia With Tau Pathology

in Stem Cell Research

Rebekka Kühn
Aayushi Mahajan
Peter Canoll
Gunnar Hargus

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.766773

9,210 views
15 citations

Original Research

Published on 06 Aug 2021

A Model of Waardenburg Syndrome Using Patient-Derived iPSCs With a SOX10 Mutation Displays Compromised Maturation and Function of the Neural Crest That Involves Inner Ear Development

in Molecular and Cellular Pathology

Jie Wen
Jian Song
Yijiang Bai
Yalan Liu
Xinzhang Cai
Lingyun Mei
Lu Ma
Chufeng He
Yong Feng

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.720858

8,362 views
10 citations

Original Research

Published on 06 Jan 2025

Modeling of auditory neuropathy spectrum disorders associated with the TEME43 variant reveals impaired gap junction function of iPSC-derived glia-like support cells

in Neuroplasticity and Development

Xiaoming Kang
Lu Ma
Jie Wen
Wei Gong
Xianlin Liu
Yihan Hu
Zhili Feng
Qiancheng Jing
Yuexiang Cai
Sijun Li

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1457874

2,738 views

Original Research

Published on 04 Feb 2022

Partial Monosomy 21 Mirrors Gene Expression of Trisomy 21 in a Patient-Derived Neuroepithelial Stem Cell Model

in Genetics of Common and Rare Diseases

Jakob Schuy
Jesper Eisfeldt
Maria Pettersson
Niloofar Shahrokhshahi
Mohsen Moslem
Daniel Nilsson
Niklas Dahl
Mansoureh Shahsavani
Anna Falk
Anna Lindstrand

Frontiers in Genetics

doi 10.3389/fgene.2021.803683

4,787 views
3 citations

Original Research

Published on 14 Feb 2024

Gene editing improves endoplasmic reticulum-mitochondrial contacts and unfolded protein response in Friedreich’s ataxia iPSC-derived neurons

in Neuropharmacology

Priyanka Mishra
Anusha Sivakumar
Avalon Johnson
Carla Pernaci
Anna S. Warden
Lilas Rony El-Hachem
Emily Hansen
Rafael A. Badell-Grau
Veenita Khare
Gabriela Ramirez

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1323491

13,803 views
12 citations

Review

Published on 02 Jan 2026

Research progress of stem cells in the treatment of atherosclerosis

in Stem Cell Research

Peifei Shi
Chao Ren
Hongjie Tong

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1722416

1,900 views

Original Research

Published on 11 Apr 2023

Modelling the erythroblastic island niche of dyserythropoietic anaemia type IV patients using induced pluripotent stem cells

in Stem Cell Research

Alisha May
Telma Ventura
Antonella Fidanza
Helena Volmer
Helen Taylor
Nicola Romanò
Sunita L. D’Souza
James J. Bieker
Lesley M. Forrester

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2023.1148013

4,234 views
6 citations

Review

Published on 15 Jun 2022

Genetic Manipulation Strategies for β-Thalassemia: A Review

in Pediatric Hematology and Hematological Malignancies

Nur Atikah Zakaria
Rosnah Bahar
Wan Zaidah Abdullah
Abdul Aziz Mohamed Yusoff
Shaharum Shamsuddin
Ridhwan Abdul Wahab
Muhammad Farid Johan

Frontiers in Pediatrics

doi 10.3389/fped.2022.901605

18,652 views
12 citations

Articles

Studying Abnormal Chromosomal Diseases Using Patient-Derived Induced Pluripotent Stem Cells

Generation and Characterization of iPS Cells Derived from APECED Patients for Gene Correction

Development of patient-specific iPSC-based epilepsy models and identification of differentially expressed genes for disease mechanisms

Disruption of the autism-associated gene SCN2A alters synaptic development and neuronal signaling in patient iPSC-glutamatergic neurons

A cross-correction gene therapy approach for CDKL5 deficiency disorder improves the pathological phenotype of CDD patient-derived cortical organoids

Generation and characterization of NGLY1 patient-derived midbrain organoids

Human Induced Pluripotent Stem Cell Models of Frontotemporal Dementia With Tau Pathology

A Model of Waardenburg Syndrome Using Patient-Derived iPSCs With a SOX10 Mutation Displays Compromised Maturation and Function of the Neural Crest That Involves Inner Ear Development

Modeling of auditory neuropathy spectrum disorders associated with the TEME43 variant reveals impaired gap junction function of iPSC-derived glia-like support cells

Partial Monosomy 21 Mirrors Gene Expression of Trisomy 21 in a Patient-Derived Neuroepithelial Stem Cell Model

Gene editing improves endoplasmic reticulum-mitochondrial contacts and unfolded protein response in Friedreich’s ataxia iPSC-derived neurons

Research progress of stem cells in the treatment of atherosclerosis

Modelling the erythroblastic island niche of dyserythropoietic anaemia type IV patients using induced pluripotent stem cells

Genetic Manipulation Strategies for β-Thalassemia: A Review