Pde4 Inhibition | List of Frontiers open access articles

Original Research

Published on 15 Sep 2023

A preliminary study of phosphodiesterases and adenylyl cyclase signaling pathway on red blood cell deformability of sickle cell patients

in Red Blood Cell Physiology

Evrim Goksel
Elif Ugurel
Elie Nader
Camille Boisson
Ingrid Muniansi
Philippe Joly
Celine Renoux
Alexandra Gauthier
Philippe Connes
Ozlem Yalcin

Frontiers in Physiology

doi 10.3389/fphys.2023.1215835

2,829 views
5 citations

Mini Review

Published on 12 Mar 2020

Inhaled Phosphodiesterase 4 (PDE4) Inhibitors for Inflammatory Respiratory Diseases

in Respiratory Pharmacology

Jonathan E. Phillips

Frontiers in Pharmacology

doi 10.3389/fphar.2020.00259

55,348 views
106 citations

Original Research

Published on 18 Aug 2020

NCS 613, a Potent PDE4 Inhibitor, Displays Anti-Inflammatory and Anti-Proliferative Properties on A549 Lung Epithelial Cells and Human Lung Adenocarcinoma Explants

in Inflammation Pharmacology

Issaka Yougbare
Lazare Belemnaba
Caroline Morin
Abdurazzag Abusnina
Yannick F. Senouvo
Thérèse Keravis
Claire Lugnier
Eric Rousseau

Frontiers in Pharmacology

doi 10.3389/fphar.2020.01266

4,395 views
12 citations

Case Report

Published on 27 Oct 2020

Case Report: Apremilast for Therapy-Resistant Pemphigus Vulgaris

in Autoimmune and Autoinflammatory Disorders

Katharina Meier
Julia Holstein
Farzan Solimani
Jens Waschke
Kamran Ghoreschi

Frontiers in Immunology

doi 10.3389/fimmu.2020.588315

8,200 views
26 citations

Original Research

Published on 22 Mar 2019

Rolipram, a PDE4 Inhibitor, Enhances the Inotropic Effect of Rat Heart by Activating SERCA2a

in Experimental Pharmacology and Drug Discovery

Huili Huang
Ming Xie
Li Gao
Wenhui Zhang
Xiaojia Zhu
Yuwei Wang
Wei Li
Rongrong Wang
Kesu Chen
Mohamed Boutjdir

Frontiers in Pharmacology

doi 10.3389/fphar.2019.00221

6,471 views
12 citations

Original Research

Published on 23 Aug 2016

Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation

in Inflammation Pharmacology

Amanda G. Vang
Chaitali Basole
Hongli Dong
Rebecca K. Nguyen
William Housley
Linda Guernsey
Alexander J. Adami
Roger S. Thrall
Robert B. Clark
Paul M. Epstein

Frontiers in Pharmacology

doi 10.3389/fphar.2016.00259

9,077 views
28 citations

Original Research

Published on 08 Jan 2026

Pharmacological characterization and preclinical evaluation of 11h: a novel, brain-penetrant PDE4 inhibitor for neurological disorders

in Experimental Pharmacology and Drug Discovery

Jacob Lackovic
Sougata Dey
Sara Jane Ward
Nigel H. Greig
David Tweedie
Nassim Beiranvand
Uksha Saini
Dev Chatterjee
Atul Varadhachary

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1720327

1,355 views

Articles

A preliminary study of phosphodiesterases and adenylyl cyclase signaling pathway on red blood cell deformability of sickle cell patients

Inhaled Phosphodiesterase 4 (PDE4) Inhibitors for Inflammatory Respiratory Diseases

NCS 613, a Potent PDE4 Inhibitor, Displays Anti-Inflammatory and Anti-Proliferative Properties on A549 Lung Epithelial Cells and Human Lung Adenocarcinoma Explants

Case Report: Apremilast for Therapy-Resistant Pemphigus Vulgaris

Rolipram, a PDE4 Inhibitor, Enhances the Inotropic Effect of Rat Heart by Activating SERCA2a

Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation

Pharmacological characterization and preclinical evaluation of 11h: a novel, brain-penetrant PDE4 inhibitor for neurological disorders