Preclinical Stage | List of Frontiers open access articles

Original Research

Published on 02 Oct 2025

Psychosocial work environment beyond WEIRD: meta-analytic and psychometric evidence on the Job Content Questionnaire

in Quantitative Psychology and Measurement

Adrián García-Selva
Beatriz Martín-del-Río
Marcelo Leiva-Bianchi

Frontiers in Psychology

doi 10.3389/fpsyg.2025.1642607

1,464 views

Original Research

Published on 02 Oct 2025

Ibrutinib combined with rituximab and high-dose methotrexate in newly diagnosed primary CNS diffuse large B-cell lymphoma: a pilot study with long-term follow-up

in Hematologic Malignancies

Yixian Guo
Yongzhi Shan
Yueshan Piao
Xiaoli Chang
Dongmei Zou
Qiang Ma
Yukui Wei
Geng Xu
Yaming Wang
Dandan Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1669385

647 views

Original Research

Published on 02 Oct 2025

The relationship between structural characteristics of long-term care institutions and their initial operating budgets

in Aging and Public Health

Xiaojing Wang
Peter C. Coyte

Frontiers in Public Health

doi 10.3389/fpubh.2025.1669451

198 views

Original Research

Published on 02 Oct 2025

Nanoplastic alters soybean microbiome across rhizocompartments level and symbiosis via flavonoid-mediated pathways

in Plant Cell Biology

Muhammad Shoaib
Gen Li
Xinru Liu
Muhammad Arshad
Huijuan Zhang
Muhammad Asif
Marian Brestic
Milan Skalicky
Jun Wu
Shixiang Zhang

Frontiers in Plant Science

doi 10.3389/fpls.2025.1676933

1,449 views

Original Research

Published on 02 Oct 2025

Multi-omics and machine learning identify novel biomarkers and therapeutic targets of COVID-19

in Viral Immunology

Yumei Zhou
Pengbei Fan
Haiyun Zhang
Shuai Han
Minghua Bai
Ji Wang
Qi Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671936

481 views

Systematic Review

Published on 02 Oct 2025

Malignant transformation rate of oral precancerous disorders to oral cancer: systematic review and meta-analysis of the current evidence

in Oral Cancers

Maryam Khodadadi
Mohammadmehdi Khodadadi

Frontiers in Oral Health

doi 10.3389/froh.2025.1673474

370 views

Case Report

Published on 02 Oct 2025

Secukinumab treatment in a pediatric patient with corticosteroid-intolerant pyoderma gangrenosum: a case report

in Dermatology

Wang Liwei
Qian Yihong
Tan Fei
Yuan Chao

Frontiers in Medicine

doi 10.3389/fmed.2025.1676980

481 views

Original Research

Published on 02 Oct 2025

Harnessing desert resources: a comparative study of microgreens growth, nutrient dynamics, and performance in desert sand and rockwool

in Crop and Product Physiology

Drishya Nishanth
Chythra Somanathan Nair
Ramya Manoharan
Radhakrishnan Subramanian
Zienab F. R. Ahmed
Abdul Jaleel

Frontiers in Plant Science

doi 10.3389/fpls.2025.1677009

716 views

Case Report

Published on 02 Oct 2025

Case report of squamous cell carcinoma secondary to recurrent anal fistula

in Gastrointestinal Cancers: Colorectal Cancer

Qin-Bing Zhu
Jing Zhang
Chen-Yuan Liu
Hui Ye
Shi-Ping Huang
Ya-Hong Xue

Frontiers in Oncology

doi 10.3389/fonc.2025.1673829

607 views

Original Research

Published on 02 Oct 2025

Multi-omics analyses inform mechanisms of immunotherapy response in pancreatic cancer

in Cancer Immunity and Immunotherapy

Mengyao Wu
Ge Li
Yecheng Li
Kai Chen
Mengdan Xu
Dapeng Li
Caihua Xu
Meng Shen
Wei Li
Jinming Cao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1673098

238 views

Review

Published on 02 Oct 2025

Role of lipocalin-2 in amyotrophic lateral sclerosis

in Neuroinflammation and Neuropathy

Zhuoya Wang
Wen Cao
Dongsheng Fan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1672903

816 views

Original Research

Published on 02 Oct 2025

Data-driven models for human–structure interaction based on MLP and NARX neural networks

in Computational Methods in Structural Engineering

Daniel Mena-Sanchez
Natividad Garcia-Troncoso
Wilfredo Alfonso
Albert R. Ortiz
Daniel Gomez

Frontiers in Built Environment

doi 10.3389/fbuil.2025.1672716

705 views

Brief Research Report

Published on 02 Oct 2025

Regionally adaptive physical training for university students considering environmental and social disparities

in Environmental Health and Exposome

Svetlana Kondratenko
Meruert Tuyakbaeva
Galiya Madiyeva
Saule Arkabaeva
Ali Zhalel
Natalia Shepetyuk

Frontiers in Public Health

doi 10.3389/fpubh.2025.1679354

379 views

Systematic Review

Published on 02 Oct 2025

Algorithms on the rise: a machine learning–driven survey of prostate cancer literature

in Genitourinary Oncology

Simin Gu
Jiajun Chen
Chunyan Fan
Xiaodong Huang
Linbo Li
Hua Zhang

Frontiers in Oncology

doi 10.3389/fonc.2025.1675459

468 views

Perspective

Published on 02 Oct 2025

Solving the mystery of emergency medicine: medically unexplained syndromes

in Emergency Health Services

Csaba Dioszeghy
Craig Prentice

Frontiers in Disaster and Emergency Medicine

doi 10.3389/femer.2025.1674150

177 views

Original Research

Published on 02 Oct 2025

Association between metabolic activity of visceral adipose tissue and retinal vein occlusion: a preliminary 18F-FDG PET/CT study

in Endocrinology of Aging

Kwang-Eon Choi
Chanmin Joung
Eungyu Yoon
Hyun Woo Chung
Ki Joo Pahk
Kisoo Pahk

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1679216

1,017 views

Articles

Psychosocial work environment beyond WEIRD: meta-analytic and psychometric evidence on the Job Content Questionnaire

Ibrutinib combined with rituximab and high-dose methotrexate in newly diagnosed primary CNS diffuse large B-cell lymphoma: a pilot study with long-term follow-up

The relationship between structural characteristics of long-term care institutions and their initial operating budgets

Nanoplastic alters soybean microbiome across rhizocompartments level and symbiosis via flavonoid-mediated pathways

Multi-omics and machine learning identify novel biomarkers and therapeutic targets of COVID-19

Malignant transformation rate of oral precancerous disorders to oral cancer: systematic review and meta-analysis of the current evidence

Secukinumab treatment in a pediatric patient with corticosteroid-intolerant pyoderma gangrenosum: a case report

Harnessing desert resources: a comparative study of microgreens growth, nutrient dynamics, and performance in desert sand and rockwool

Case report of squamous cell carcinoma secondary to recurrent anal fistula

Multi-omics analyses inform mechanisms of immunotherapy response in pancreatic cancer

Role of lipocalin-2 in amyotrophic lateral sclerosis

Data-driven models for human–structure interaction based on MLP and NARX neural networks

Regionally adaptive physical training for university students considering environmental and social disparities

Algorithms on the rise: a machine learning–driven survey of prostate cancer literature

Solving the mystery of emergency medicine: medically unexplained syndromes

Association between metabolic activity of visceral adipose tissue and retinal vein occlusion: a preliminary 18F-FDG PET/CT study