Probenecid | List of Frontiers open access articles

Original Research

Published on 11 Jul 2018

Probenecid Pre-treatment Downregulates the Kidney Cl-/HCO3- Exchanger (Pendrin) and Potentiates Hydrochlorothiazide-Induced Diuresis

in Renal Physiology and Pathophysiology

Sharon Barone
Jie Xu
Kamyar Zahedi
Marybeth Brooks
Manoocher Soleimani

Frontiers in Physiology

doi 10.3389/fphys.2018.00849

5,391 views
16 citations

Original Research

Published on 06 Oct 2021

Effect of Probenecid on Endothelial Cell Growth Rate and Retinal Angiogenesis in an Oxygen-Induced Retinopathy Model

in Translational Pharmacology

Jingbo Jiang
Weiming Ou
Xianqiong Luo
Jianwen Xiang
Guosheng Liu
Shuiqing Huang
Hongping Li
Longkai He
Jiamin Gan
Shasha Han

Frontiers in Pharmacology

doi 10.3389/fphar.2021.717351

4,865 views
6 citations

Original Research

Published on 11 May 2018

Probenecid Disrupts a Novel Pannexin 1-Collapsin Response Mediator Protein 2 Interaction and Increases Microtubule Stability

in Cellular Neurophysiology

Xiaoxue Xu
Leigh E. Wicki-Stordeur
Juan C. Sanchez-Arias
Mei Liu
Maria S. Weaver
Catherine S. W. Choi
Leigh A. Swayne

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2018.00124

6,632 views
36 citations

Original Research

Published on 30 Apr 2025

Pharmacological mechanisms of probenecid for SARS-CoV-2 and RSV co-infection: findings of system pharmacology, molecular docking, molecular dynamics simulation, and structure–activity relationship

in Virology

Junbin Hong
Zhendong Guo
XiaoMei Huang
Peng Wu
Xinying Chen
Xiaoyi Liu
Jinghua Yang
Yanni Lai

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1552603

4,102 views

Original Research

Published on 19 May 2022

Neuroprotective Effects of the Pannexin-1 Channel Inhibitor: Probenecid on Spinal Cord Injury in Rats

in Neuroplasticity and Development

Qi Qi
Xiao-Xuan Wang
Jing-Lu Li
Yu-Qing Chen
Jian-Rong Chang
Jin Xi
He-Zuo Lü
Yu-Xin Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.848185

3,843 views
12 citations

Original Research

Published on 23 Mar 2022

Probenecid-Blocked Pannexin-1 Channel Protects Against Early Brain Injury via Inhibiting Neuronal AIM2 Inflammasome Activation After Subarachnoid Hemorrhage

in Multiple Sclerosis and Neuroimmunology

Yonghe Zheng
Wenwen Tang
Hanhai Zeng
Yucong Peng
Xiaobo Yu
Feng Yan
Shenglong Cao

Frontiers in Neurology

doi 10.3389/fneur.2022.854671

5,279 views
27 citations

Original Research

Published on 14 Aug 2018

Extracellular ATP Regulates CD73 and ABCC6 Expression in HepG2 Cells

in Cellular Biochemistry

Fabio Martinelli
Flavia Cuviello
Maria C. Pace
Maria F. Armentano
Rocchina Miglionico
Angela Ostuni
Faustino Bisaccia

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2018.00075

6,014 views
21 citations

Original Research

Published on 09 Aug 2016

Inhibition of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 Regulates the Hepatobiliary Excretion and Plasma Exposure of Thienorphine and Its Glucuronide Conjugate

in Drug Metabolism and Transport

Ling-Lei Kong
Guo-Lin Shen
Zhi-Yuan Wang
Xiao-Mei Zhuang
Wei-Bin Xiao
Mei Yuan
Ze-Hui Gong
Hua Li

Frontiers in Pharmacology

doi 10.3389/fphar.2016.00242

5,587 views
21 citations

Original Research

Published on 18 Feb 2015

Drug Resistance in Cortical and Hippocampal Slices from Resected Tissue of Epilepsy Patients: No Significant Impact of P-Glycoprotein and Multidrug Resistance-Associated Proteins

in Epilepsy

Nora Sandow
Simon Kim
Claudia Raue
Dennis Päsler
Zin-Juan Klaft
Leandro Leite Antonio
Jan Oliver Hollnagel
Richard Kovacs
Oliver Kann
Peter Horn

Frontiers in Neurology

doi 10.3389/fneur.2015.00030

8,892 views
28 citations

Review

Published on 20 Aug 2025

Pannexin channels in inflammation and tumorigenesis

in Cancer Cell Biology

Mengmeng Jiang
Xiaojia Li
Keping Xie

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1647765

2,407 views
2 citations

Original Research

Published on 05 Feb 2019

Smilagenin Protects Dopaminergic Neurons in Chronic MPTP/Probenecid—Lesioned Parkinson’s Disease Models

in Cellular Neurophysiology

Xuan He
Shuangshuang Yang
Rui Zhang
Lina Hou
Jianrong Xu
Yaer Hu
Rang Xu
Hao Wang
Yongfang Zhang

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2019.00018

7,942 views
26 citations

Original Research

Published on 22 Nov 2017

Pannexin 1 Modulates Axonal Growth in Mouse Peripheral Nerves

in Cellular Neurophysiology

Steven M. Horton
Carlos Luna Lopez
Elisabeth Blevins
Holly Howarth
Jake Weisberg
Valery I. Shestopalov
Helen P. Makarenkova
Sameer B. Shah

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2017.00365

7,067 views
17 citations

Original Research

Published on 19 Mar 2020

Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease

in Cellular Neuropathology

Carolina Flores-Muñoz
Bárbara Gómez
Elena Mery
Paula Mujica
Ivana Gajardo
Claudio Córdova
Daniela Lopez-Espíndola
Claudia Durán-Aniotz
Claudio Hetz
Pablo Muñoz

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2020.00046

9,269 views
32 citations

Original Research

Published on 26 Mar 2018

Uric Acid Impairs Insulin Signaling by Promoting Enpp1 Binding to Insulin Receptor in Human Umbilical Vein Endothelial Cells

in Systems Endocrinology

Eliezer J. Tassone
Antonio Cimellaro
Maria Perticone
Marta L. Hribal
Angela Sciacqua
Francesco Andreozzi
Giorgio Sesti
Francesco Perticone

Frontiers in Endocrinology

doi 10.3389/fendo.2018.00098

6,840 views
63 citations

Correction

Published on 26 Sep 2025

Correction: Neuroprotective effects of the pannexin-1 channel inhibitor: probenecid on spinal cord injury in rats

in Neuroplasticity and Development

Qi Qi
Xiao-Xuan Wang
Jing-Lu Li
Yu-Qing Chen
Jian-Rong Chang
Jin Xi
He-Zuo Lü
Yu-Xin Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1698001

1,869 views

Original Research

Published on 21 Jun 2018

Pain Input After Spinal Cord Injury (SCI) Undermines Long-Term Recovery and Engages Signal Pathways That Promote Cell Death

Joel D. Turtle
Misty M. Strain
Joshua A. Reynolds
Yung-Jen Huang
Kuan H. Lee
Melissa K. Henwood
Sandra M. Garraway
James W. Grau

Frontiers in Systems Neuroscience

doi 10.3389/fnsys.2018.00027

6,718 views
20 citations

Articles

Probenecid Pre-treatment Downregulates the Kidney Cl-/HCO3- Exchanger (Pendrin) and Potentiates Hydrochlorothiazide-Induced Diuresis

Effect of Probenecid on Endothelial Cell Growth Rate and Retinal Angiogenesis in an Oxygen-Induced Retinopathy Model

Probenecid Disrupts a Novel Pannexin 1-Collapsin Response Mediator Protein 2 Interaction and Increases Microtubule Stability

Pharmacological mechanisms of probenecid for SARS-CoV-2 and RSV co-infection: findings of system pharmacology, molecular docking, molecular dynamics simulation, and structure–activity relationship

Neuroprotective Effects of the Pannexin-1 Channel Inhibitor: Probenecid on Spinal Cord Injury in Rats

Probenecid-Blocked Pannexin-1 Channel Protects Against Early Brain Injury via Inhibiting Neuronal AIM2 Inflammasome Activation After Subarachnoid Hemorrhage

Extracellular ATP Regulates CD73 and ABCC6 Expression in HepG2 Cells

Inhibition of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 Regulates the Hepatobiliary Excretion and Plasma Exposure of Thienorphine and Its Glucuronide Conjugate

Drug Resistance in Cortical and Hippocampal Slices from Resected Tissue of Epilepsy Patients: No Significant Impact of P-Glycoprotein and Multidrug Resistance-Associated Proteins

Pannexin channels in inflammation and tumorigenesis

Smilagenin Protects Dopaminergic Neurons in Chronic MPTP/Probenecid—Lesioned Parkinson’s Disease Models

Pannexin 1 Modulates Axonal Growth in Mouse Peripheral Nerves

Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease

Uric Acid Impairs Insulin Signaling by Promoting Enpp1 Binding to Insulin Receptor in Human Umbilical Vein Endothelial Cells

Correction: Neuroprotective effects of the pannexin-1 channel inhibitor: probenecid on spinal cord injury in rats

Pain Input After Spinal Cord Injury (SCI) Undermines Long-Term Recovery and Engages Signal Pathways That Promote Cell Death