Synthetic Compound | List of Frontiers open access articles

Original Research

Published on 03 Aug 2022

Large-scale transcriptomic analysis of coding and non-coding pathological biomarkers, associated with the tumor immune microenvironment of thyroid cancer and potential target therapy exploration

in Molecular and Cellular Pathology

Ming-Lang Shih
Bashir Lawal
Sheng-Yao Cheng
Janet O. Olugbodi
Ahmad O Babalghith
Ching-Liang Ho
Simona Cavalu
Gaber El-Saber Batiha
Sarah Albogami
Saqer S. Alotaibi

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2022.923503

6,428 views
8 citations

Original Research

Published on 16 Apr 2018

The Novel Small Molecule STK899704 Promotes Senescence of the Human A549 NSCLC Cells by Inducing DNA Damage Responses and Cell Cycle Arrest

in Pharmacology of Anti-Cancer Drugs

Chan-Woo Park
Yesol Bak
Min-Je Kim
Ganipisetti Srinivasrao
Joonsung Hwang
Nak K. Sung
Bo Yeon Kim
Jae-Hyuk Yu
Jin Tae Hong
Do-Young Yoon

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00163

6,100 views
15 citations

Original Research

Published on 25 Nov 2021

Untargeted and Targeted Metabolomics Reveal the Underlying Mechanism of Aspirin Eugenol Ester Ameliorating Rat Hyperlipidemia via Inhibiting FXR to Induce CYP7A1

in Gastrointestinal and Hepatic Pharmacology

Lu Xiao-Rong
Ma Ning
Liu Xi-Wang
Li Shi-Hong
Qin Zhe
Bai Li-Xia
Yang Ya-Jun
Li Jian-Yong

Frontiers in Pharmacology

doi 10.3389/fphar.2021.733789

6,778 views
28 citations

Original Research

Published on 20 Mar 2019

Antimicrobial and Synergistic Activity of 2,2′,4-Trihydroxybenzophenone Against Bacterial Pathogens of Poultry

in Antimicrobials, Resistance and Chemotherapy

Martha Isabel Realpe Aranda
Gabriel Andres Tafur Gómez
Mariana de Barros
Marcelo Henrique dos Santos
Leandro Licursi de Oliveira
Junnia Luisa Pena
Maria Aparecida Scatamburlo Moreira

Frontiers in Microbiology

doi 10.3389/fmicb.2019.00490

5,457 views
12 citations

Original Research

Published on 12 Jun 2024

A phase I, randomized study to evaluate the safety, tolerability, and pharmacokinetics of mefunidone in healthy subjects

in Drug Metabolism and Transport

Mai Han
Bishan Huo
Gaoyun Hu
Xin Zhang
Gang Cui
Wei Wu
Na Mi
Shixi Zhang
Jiangli Jin
Xing Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1414066

2,534 views
2 citations

Review

Published on 03 Mar 2022

Exploration of Chemical Biology Approaches to Facilitate the Discovery and Development of Novel Antibiotics

in Antimicrobial Resistance

Renata Rezende Miranda
Anutthaman Parthasarathy
André O. Hudson

Frontiers in Tropical Diseases

doi 10.3389/fitd.2022.845469

5,231 views
8 citations

Review

Published on 26 Dec 2011

The yeast three-hybrid system as an experimental platform to identify proteins interacting with small signaling molecules in plant cells: Potential and limitations

in Plant Physiology

Stéphanie Cottier
Timon Mönig
Zheming Wang
Jiří Svoboda
Wilhelm Boland
Markus Kaiser
Erich Kombrink

Frontiers in Plant Science

doi 10.3389/fpls.2011.00101

33,658 views
32 citations

Original Research

Published on 13 Jan 2021

Dl-3-n-Butylphthalide Alleviates Hippocampal Neuron Damage in Chronic Cerebral Hypoperfusion via Regulation of the CNTF/CNTFRα/JAK2/STAT3 Signaling Pathways

in Neuroinflammation and Neuropathy

Wenxian Li
Di Wei
Zheng Zhu
Xiaomei Xie
Shuqin Zhan
Ru Zhang
Guilian Zhang
Li’an Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.587403

5,522 views
18 citations

Original Research

Published on 08 Apr 2024

Effect of Dl-3-n-Butylphthalide on olfaction in rotenone-induced Parkinson’s rats

in Dementia and Neurodegenerative Diseases

Jiawei Wang
He Li
Canran Wang
Dayong Li
Yong Zhang
Meichan Shen
Xiangdong Xu
Tong Wu

Frontiers in Neurology

doi 10.3389/fneur.2024.1367973

2,670 views
3 citations

Original Research

Published on 25 Jun 2021

IIIM-941, a Stilbene Derivative Inhibits NLRP3 Inflammasome Activation by Inducing Autophagy

in Inflammation Pharmacology

Mehboob Ali
Mehak Gupta
Abubakar Wani
Ankita Sharma
Mohd Abdullaha
Dilpreet Kour
Sushil Choudhary
Sandip B. Bharate
Gurdarshan Singh
Ajay Kumar

Frontiers in Pharmacology

doi 10.3389/fphar.2021.695712

6,562 views
13 citations

Original Research

Published on 27 Feb 2018

Repeated Exposure to the “Spice” Cannabinoid JWH-018 Induces Tolerance and Enhances Responsiveness to 5-HT1A Receptor Stimulation in Male Rats

in Addictive Disorders

Joshua S. Elmore
Michael H. Baumann

Frontiers in Psychiatry

doi 10.3389/fpsyt.2018.00055

45,121 views
25 citations

Original Research

Published on 10 Dec 2025

Potential lipid-lowering effects of preussin B on inhibition of intestinal cholesterol absorption: integrative mechanisms of action and proteomic analysis

in Experimental Pharmacology and Drug Discovery

Atcharaporn Ontawong
Jakkapong Inchai
Pannita Holasut
Wararat Chiangjong
Thaweesak Chieochansin
Davide Crucitti
Adrián Mosquera Orgueira
Worarat Rojanaverawong
Thanthakan Saithong
Kornwalai Tunkaew

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1708213

1,140 views

Original Research

Published on 07 Jun 2024

Exploring the role of trifarotene against RAR-α: an investigation of expression pattern and clinicopathological significance of RAR-α in breast cancer

in Pharmacology of Anti-Cancer Drugs

Nusrat Jan
Shazia Sofi
Adel Abo Mansoor
Adil Abdelrahim
Irshad Ahmad
Abdullah Almilabairy
Fuzail Ahmad
Manzoor Ahmad Mir

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1361679

3,593 views
49 citations

Original Research

Published on 25 May 2018

Exploring the Structural Diversity in Inhibitors of α-Synuclein Amyloidogenic Folding, Aggregation, and Neurotoxicity

in Medicinal and Pharmaceutical Chemistry

Sukanya Das
Tara L. Pukala
Scott D. Smid

Frontiers in Chemistry

doi 10.3389/fchem.2018.00181

8,683 views
28 citations

Original Research

Published on 13 Dec 2024

Growth-promoting effects of self-selected microbial community on wheat seedlings in saline-alkali soil environments

in Synthetic Biology

Min Li
Wenjie Li
Chunxue Wang
Lei Ji
Kun Han
Jiahui Gong
Siyuan Dong
Hailong Wang
Xueming Zhu
Binghai Du

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1464195

3,943 views
6 citations

Articles

Large-scale transcriptomic analysis of coding and non-coding pathological biomarkers, associated with the tumor immune microenvironment of thyroid cancer and potential target therapy exploration

The Novel Small Molecule STK899704 Promotes Senescence of the Human A549 NSCLC Cells by Inducing DNA Damage Responses and Cell Cycle Arrest

Untargeted and Targeted Metabolomics Reveal the Underlying Mechanism of Aspirin Eugenol Ester Ameliorating Rat Hyperlipidemia via Inhibiting FXR to Induce CYP7A1

Antimicrobial and Synergistic Activity of 2,2′,4-Trihydroxybenzophenone Against Bacterial Pathogens of Poultry

A phase I, randomized study to evaluate the safety, tolerability, and pharmacokinetics of mefunidone in healthy subjects

Exploration of Chemical Biology Approaches to Facilitate the Discovery and Development of Novel Antibiotics

The yeast three-hybrid system as an experimental platform to identify proteins interacting with small signaling molecules in plant cells: Potential and limitations

Dl-3-n-Butylphthalide Alleviates Hippocampal Neuron Damage in Chronic Cerebral Hypoperfusion via Regulation of the CNTF/CNTFRα/JAK2/STAT3 Signaling Pathways

Effect of Dl-3-n-Butylphthalide on olfaction in rotenone-induced Parkinson’s rats

IIIM-941, a Stilbene Derivative Inhibits NLRP3 Inflammasome Activation by Inducing Autophagy

Repeated Exposure to the “Spice” Cannabinoid JWH-018 Induces Tolerance and Enhances Responsiveness to 5-HT1A Receptor Stimulation in Male Rats

Potential lipid-lowering effects of preussin B on inhibition of intestinal cholesterol absorption: integrative mechanisms of action and proteomic analysis

Exploring the role of trifarotene against RAR-α: an investigation of expression pattern and clinicopathological significance of RAR-α in breast cancer

Exploring the Structural Diversity in Inhibitors of α-Synuclein Amyloidogenic Folding, Aggregation, and Neurotoxicity

Growth-promoting effects of self-selected microbial community on wheat seedlings in saline-alkali soil environments