Systems Thinking | List of Frontiers open access articles

Original Research

Accepted on 10 Oct 2025

Knockdown of TOP2A Reverses Cisplatin 1 Resistance in Ovarian Cancer by Inhibiting 2 EMT via Ferroptosis Mediated by the 3 TP53/GPX4/SLC7A11 Axis 4

in Cancer Immunity and Immunotherapy

Liu Xinyue
Junxia Wang
Yangyu Liu
Yan Han
Zhichao Qin
Yu Wang
Shanxiang Gao
Xinghua Li
Yuping Suo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675373

386 views

Original Research

Accepted on 10 Oct 2025

Targeting Cystatin F Activation Enhances NK Cell Cytotoxicity in Glioblastoma Models

in Cancer Immunity and Immunotherapy

Emanuela Senjor
Anamarija Habič
Urban Švajger
Ana Mitrović
Matic Proj
Andrej Porčnik
Borut Prestor
Miha Jerala
Matic Bošnjak
Stanislav Gobec

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708281

357 views

Original Research

Accepted on 10 Oct 2025

B cell receptor repertoire reconstitution in patients with neuromyelitis optica spectrum disorder receiving B-cell depletion therapy

in B Cell Biology

Hyo Jae Kim
Wangyong Shin
Dayoung Seo
Inhye Jang
Jihong Ryu
Lynkyung Choi
Jinhee Kim
Hyunjin Kim
Young-Min Lim
Eun-Jae LEE

Frontiers in Immunology

doi 10.3389/fimmu.2025.1673508

357 views

Original Research

Accepted on 10 Oct 2025

Single-Cell Transcriptomics Unravels the Early Immune Landscape of Renal Allograft Rejection and Nominates Ccl3-Ccr5 as a Therapeutic Target

in Alloimmunity and Transplantation

Fanchao Wei
Zhaoxiang Wang
Ruochen Qi
Jingliang Zhang
Shichao Han
Changhong Shi
Tong Lu
Zhite Zhao
Zhengxuan Li
Lang Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663251

331 views

Original Research

Accepted on 10 Oct 2025

Identification of CAF signature genes and construction of CAF-based risk signature in hepatocellular carcinoma by multi-omics analysis

in Inflammation

Wenchen Qian
Kezhi Wu
Bowen Ni
Haojie Zheng
Yawei Liu
Manlan Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690174

353 views

Brief Research Report

Accepted on 10 Oct 2025

The Power of Parenting: Mitigating Conduct Problems among Adolescents Carrying Genetic Risk

in Developmental Psychopathology and Mental Health

Maia Choi
Genevieve F Dash
Sally Kuo
Fazil Aliev
Holly E Poore
Sarah J Brislin
Danielle M Dick

Frontiers in Child and Adolescent Psychiatry

doi 10.3389/frcha.2025.1597229

343 views

Original Research

Accepted on 10 Oct 2025

How Does Emotional Exhaustion Among Chinese College Students Affect Mental Health? A Mixed-Methods Study in Zhejiang, China

in Public Mental Health

Longyuan Jiang
Chengcheng Fei
Lefei Fang
Yuan Fang
Shujing Dai
Jiakun Tian
Wei Wu
Yuanqi Xu
Meili Zhang
Haiyan Yu

Frontiers in Public Health

doi 10.3389/fpubh.2025.1669092

372 views

Original Research

Accepted on 10 Oct 2025

Tai Chi as a preventive intervention for improving mental and physical health in non-depressed college students with high perceived stress.

in Public Mental Health

JingYu Sun
Ke Yao
Rongji Zhao
Hanfei Li
Antonio Cicchella

Frontiers in Public Health

doi 10.3389/fpubh.2025.1613384

381 views

Original Research

Accepted on 10 Oct 2025

18F-DOPA uptake illustration acts as an indicator for renal sympathetic activity

in Medical Physics and Imaging

Rui Wu
Saijian Shi
Yuanjie Huang
Feng Tian
Jiqin Hou
Xiangqing Kong
Longxiang Sheng
Tao Zhang
Lijun Tang
Wei Sun

Frontiers in Physiology

doi 10.3389/fphys.2025.1569699

345 views

Review

Accepted on 10 Oct 2025

Digital sovereignty of physical education teachers in Germany: A situation analysis (2017-2021) on the gap between educational policies and practical implementation in further physical education teacher trainings

in Teacher Education

Fides Berkel
Daniel Bohm
Hagen Wulff
Gabriel Reith
Thomas Wendeborn

Frontiers in Education

doi 10.3389/feduc.2025.1544886

413 views

Perspective

Accepted on 10 Oct 2025

What can ANS signals tell us about motor learning? An implication for better assessment of cognitive contribution to motor learning

in Emotion Regulation and Processing

Atsushi Yokoi

Frontiers in Behavioral Neuroscience

doi 10.3389/fnbeh.2025.1715460

Review

Accepted on 10 Oct 2025

Modulating M1/M2 Macrophage Polarization with plant metabolites: A Therapeutic Strategy for Rheumatoid Arthritis

in Ethnopharmacology

Yuanyuan Yang
Xiaoyu Wang
Youqian Kong
Yang Pan
Xiadong Yang
Ziyi Zhang
Zeguang Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651763

136 views

Original Research

Accepted on 10 Oct 2025

Predicting First-Time Anaphylaxis in the Elderly Using Stacked Machine Learning and Population Registers

in Drug, Venom & Anaphylaxis

Toni Mora
David Roche
Rosa Muñoz Cano

Frontiers in Allergy

doi 10.3389/falgy.2025.1655662

190 views

Correction

Accepted on 10 Oct 2025

Correction: Biomechanically Optimized 3D-Printed Titanium Prostheses with Stiffener Arrangement for Critical Femoral Diaphyseal Defects: Early Weight-Bearing Capacity and Combat Readiness Validated Through Integrated Biomechanical-FEA Approach

in Biomechanics

Guosen Li
Hao Li
Da Liu
Rui Yi
Yi Cui
Hong-Da Lao
Xiao-Yang Nie
Min Zhao
ChengFei Du
Yongqing Xu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1709142

Original Research

Accepted on 10 Oct 2025

Subzero cell division, respiration, and genomic traits of cryophilic Arthrobacter agilis Ant-EH-1 isolated from cold-arid Antarctic mineral soils

in Extreme Microbiology

Claudia Wood
Elisse Magnuson
Ethan Harrop
Elizabeth Trembath-Reichert
Mary Beth Wilhelm
Jacqueline Goordial

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1620620

141 views

Conceptual Analysis

Accepted on 10 Oct 2025

The Neuromorphic Cyber-Twin: A Conceptual Architecture for Cognitive Defense in Digital Twin Ecosystems

in Cybersecurity and Privacy

Nida Nasir
Hussam Al Hamadi

Frontiers in Big Data

doi 10.3389/fdata.2025.1659757

250 views

Articles

Knockdown of TOP2A Reverses Cisplatin 1 Resistance in Ovarian Cancer by Inhibiting 2 EMT via Ferroptosis Mediated by the 3 TP53/GPX4/SLC7A11 Axis 4

Targeting Cystatin F Activation Enhances NK Cell Cytotoxicity in Glioblastoma Models

B cell receptor repertoire reconstitution in patients with neuromyelitis optica spectrum disorder receiving B-cell depletion therapy

Single-Cell Transcriptomics Unravels the Early Immune Landscape of Renal Allograft Rejection and Nominates Ccl3-Ccr5 as a Therapeutic Target

Identification of CAF signature genes and construction of CAF-based risk signature in hepatocellular carcinoma by multi-omics analysis

The Power of Parenting: Mitigating Conduct Problems among Adolescents Carrying Genetic Risk

How Does Emotional Exhaustion Among Chinese College Students Affect Mental Health? A Mixed-Methods Study in Zhejiang, China

Tai Chi as a preventive intervention for improving mental and physical health in non-depressed college students with high perceived stress.

18F-DOPA uptake illustration acts as an indicator for renal sympathetic activity

Digital sovereignty of physical education teachers in Germany: A situation analysis (2017-2021) on the gap between educational policies and practical implementation in further physical education teacher trainings

What can ANS signals tell us about motor learning? An implication for better assessment of cognitive contribution to motor learning

Modulating M1/M2 Macrophage Polarization with plant metabolites: A Therapeutic Strategy for Rheumatoid Arthritis

Predicting First-Time Anaphylaxis in the Elderly Using Stacked Machine Learning and Population Registers

Correction: Biomechanically Optimized 3D-Printed Titanium Prostheses with Stiffener Arrangement for Critical Femoral Diaphyseal Defects: Early Weight-Bearing Capacity and Combat Readiness Validated Through Integrated Biomechanical-FEA Approach

Subzero cell division, respiration, and genomic traits of cryophilic Arthrobacter agilis Ant-EH-1 isolated from cold-arid Antarctic mineral soils

The Neuromorphic Cyber-Twin: A Conceptual Architecture for Cognitive Defense in Digital Twin Ecosystems