Threats To Validity | List of Frontiers open access articles

Original Research

Published on 07 Nov 2025

Nrf2-mediated mechanistic pathways of celastrol nephroprotection: disrupting the oxidative-inflammatory-apoptotic axis in cypermethrin toxicity

in Experimental Pharmacology and Drug Discovery

Ashraf Albrakati

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1670444

431 views

Brief Research Report

Published on 07 Nov 2025

Salivary oxidative stress persists in inflammatory bowel disease regardless of biological treatment response

in Gastrointestinal and Hepatic Pharmacology

Elisabetta Bigagli
Tommaso Innocenti
Gabriele Dragoni
Francesco Pindozzi
Andrea Galli
Maura Lodovici
Cristina Luceri

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699252

483 views

Original Research

Published on 07 Nov 2025

Requirement of ClpX for CtsR dissociation from its operator elements upon heat stress in Bacillus subtilis

in Microbial Physiology and Metabolism

Marco Harms
Chelsea Kaden
Larissa M. Busch
Vishnu M. Dhople
Ulf Gerth
Manuela Gesell Salazar
Stephan Michalik
Zhanetta Zhatarova
Uwe Völker
Alexander Reder

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1699655

770 views

Original Research

Published on 07 Nov 2025

Caregivers' burden and its influencing factors among parents of children with asthma and comorbidities: a cross-sectional study

in Children and Health

Xin Yi
Kejimu Sunzi
Jie Liu
Fang Yang
Xia Wu
Dan Bi
Qin Huang
Lifei Dai

Frontiers in Public Health

doi 10.3389/fpubh.2025.1698723

474 views

Original Research

Published on 07 Nov 2025

Hearing preservation outcomes with motorized cochlear implant electrode insertion: matched-cohort observations

in Otorhinolaryngology - Head and Neck Surgery

Yannik Oetiker
Philipp Aebischer
Marco Caversaccio
Georgios Mantokoudis
Stefan Weder

Frontiers in Surgery

doi 10.3389/fsurg.2025.1700744

324 views

Review

Published on 07 Nov 2025

DNA methylation and immune regulation in osteoporosis: emerging epigenetic targets for drug discovery

in Experimental Pharmacology and Drug Discovery

Yingli Yang
Yao Yao
Xiaoyu Cai
Yaqi Tao
Zhengbing Zhuge
Jianhong Zhou
Caihong Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688305

324 views

Original Research

Published on 07 Nov 2025

Impact of biologic therapy on blood cell indices and exacerbation risk in severe asthma: predictive value of the neutrophil-to-eosinophil ratio

in Mechanisms in Allergy

Mona Al-Ahmad
Asmaa Ali
Wafaa Talat

Frontiers in Allergy

doi 10.3389/falgy.2025.1691886

441 views

Original Research

Published on 07 Nov 2025

Composite shoreline-retreat workflow (CoShReW): a case study on the Andalusian coast

in Coastal Ocean Processes

Arnau Garcia Tort
Paula Gomes da Silva
Erica Pellón
Verónica Cánovas
Mauricio González
Raúl Medina
Antonio Henrique da Fontoura Klein

Frontiers in Marine Science

doi 10.3389/fmars.2025.1695289

814 views

Review

Published on 07 Nov 2025

Dysfunctions of sleep and the circadian rhythm in Huntington’s disease

in Dementia and Neurodegenerative Diseases

Paulina Kaczmarska
Monika Rudzińska-Bar

Frontiers in Neurology

doi 10.3389/fneur.2025.1693307

541 views

Brief Research Report

Published on 07 Nov 2025

Mindfulness training combined with cold water immersion effects on mood and perception of executive functioning in middle-aged and older adults: a pilot study

in Aging and Public Health

Ambra Gentile
Sara Vivirito
Musa Kirkar
Konstantinos Paschos
Luka Tuđan
Jakub Kulhánek
Pelin Öztürk
Marianna Alesi

Frontiers in Public Health

doi 10.3389/fpubh.2025.1693026

302 views

Original Research

Published on 07 Nov 2025

Impact of early vs. delayed intravenous magnesium sulfate on clinical outcomes in pediatric severe asthma: a retrospective cohort study

in Pediatric Emergency Medicine

Mohammid Alzain
Sajjad Alkhadem
Rafa Alotbi
Ibrahim Alammari
Norah Aljabri
Reem Almijlad
Shahd Abureesh
Hadeel Alharbi
Rawan Alrashed
Yara Algoraini

Frontiers in Disaster and Emergency Medicine

doi 10.3389/femer.2025.1689282

611 views

Original Research

Published on 07 Nov 2025

Biomechanical optimization study of posterior tilt extension stems in the repair of tibial plateau bone defects

in Biomechanics

Yong Wang
Ruihu Hao
Lin Guo
Xiaoyu Zhou

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1688915

225 views

Perspective

Published on 07 Nov 2025

The role of early human development and multidimensional enhancements in driving space adaptation and Universal Cognition

in Space Exploration

Marta Ferraz

Frontiers in Space Technologies

doi 10.3389/frspt.2025.1705650

625 views

Correction

Published on 07 Nov 2025

Correction: PFOA biomonitoring and kidney cancer risk: a meta-analysis of serum levels

in Cancer Epidemiology and Prevention

Francesca Spyrakis
Gioele Antonio Tiburtini
Stefania Bruno
Tommaso A. Dragani
Francesca Colombo

Frontiers in Oncology

doi 10.3389/fonc.2025.1705495

123 views

Original Research

Published on 07 Nov 2025

STAT3 as a critical target of Sijunzi Decoction in the treatment of gastric cancer: evidence from integrated network pharmacology and experimental validation

in Molecular Diagnostics and Therapeutics

XiaoYu Luo
GuiPing Xie
QianYing Tan
YaoHui Wang
HaiDan Wang
Jing Zhai

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1683806

350 views

Original Research

Published on 07 Nov 2025

Joint association of indoor allergens, endotoxins, heavy metals, and parabens with allergy-related outcomes in U. S. adults

in Environmental Health and Exposome

Min Xue
Xiaoling Wei
Yun Zhang
Xiang Ma

Frontiers in Public Health

doi 10.3389/fpubh.2025.1683381

519 views

Articles

Nrf2-mediated mechanistic pathways of celastrol nephroprotection: disrupting the oxidative-inflammatory-apoptotic axis in cypermethrin toxicity

Salivary oxidative stress persists in inflammatory bowel disease regardless of biological treatment response

Requirement of ClpX for CtsR dissociation from its operator elements upon heat stress in Bacillus subtilis

Caregivers' burden and its influencing factors among parents of children with asthma and comorbidities: a cross-sectional study

Hearing preservation outcomes with motorized cochlear implant electrode insertion: matched-cohort observations

DNA methylation and immune regulation in osteoporosis: emerging epigenetic targets for drug discovery

Impact of biologic therapy on blood cell indices and exacerbation risk in severe asthma: predictive value of the neutrophil-to-eosinophil ratio

Composite shoreline-retreat workflow (CoShReW): a case study on the Andalusian coast

Dysfunctions of sleep and the circadian rhythm in Huntington’s disease

Mindfulness training combined with cold water immersion effects on mood and perception of executive functioning in middle-aged and older adults: a pilot study

Impact of early vs. delayed intravenous magnesium sulfate on clinical outcomes in pediatric severe asthma: a retrospective cohort study

Biomechanical optimization study of posterior tilt extension stems in the repair of tibial plateau bone defects

The role of early human development and multidimensional enhancements in driving space adaptation and Universal Cognition

Correction: PFOA biomonitoring and kidney cancer risk: a meta-analysis of serum levels

STAT3 as a critical target of Sijunzi Decoction in the treatment of gastric cancer: evidence from integrated network pharmacology and experimental validation

Joint association of indoor allergens, endotoxins, heavy metals, and parabens with allergy-related outcomes in U. S. adults