Tr1 | List of Frontiers open access articles

Original Research

Published on 24 Feb 2023

Highly purified and functionally stable in vitro expanded allospecific Tr1 cells expressing immunosuppressive graft-homing receptors as new candidates for cell therapy in solid organ transplantation

in Alloimmunity and Transplantation

Saúl Arteaga-Cruz
Arimelek Cortés-Hernández
Evelyn Katy Alvarez-Salazar
Katya Rosas-Cortina
Christian Aguilera-Sandoval
Luis E. Morales-Buenrostro
Josefina M. Alberú-Gómez
Gloria Soldevila

Frontiers in Immunology

doi 10.3389/fimmu.2023.1062456

6,657 views
7 citations

Review

Published on 26 Apr 2021

Tr1 Cells as a Key Regulator for Maintaining Immune Homeostasis in Transplantation

in Alloimmunity and Transplantation

Yun Song
Ning Wang
Lihua Chen
Liang Fang

Frontiers in Immunology

doi 10.3389/fimmu.2021.671579

19,527 views
64 citations

Review

Published on 10 Jun 2021

The Yin and Yang of Type 1 Regulatory T Cells: From Discovery to Clinical Application

in Alloimmunity and Transplantation

Ece Canan Sayitoglu
Robert Arthur Freeborn
Maria Grazia Roncarolo

Frontiers in Immunology

doi 10.3389/fimmu.2021.693105

9,527 views
27 citations

Original Research

Published on 19 Nov 2018

Beyond Type 1 Regulatory T Cells: Co-expression of LAG3 and CD49b in IL-10-Producing T Cell Lineages

in T Cell Biology

Weishan Huang
Sabrina Solouki
Chavez Carter
Song-Guo Zheng
Avery August

Frontiers in Immunology

doi 10.3389/fimmu.2018.02625

12,431 views
50 citations

Original Research

Published on 04 Jul 2022

CD49b Targeting Inhibits Tumor Growth and Boosts Anti-tumor Immunity

in Cancer Immunity and Immunotherapy

Pamina Contreras-Kallens
Felipe Gálvez-Jirón
Javiera De Solminihac
Ahmed Elhusseiny
Wilfredo A. González-Arriagada
Francisca Alcayaga-Miranda
Randolph J. Noelle
Karina Pino-Lagos

Frontiers in Oncology

doi 10.3389/fonc.2022.928498

5,073 views
1 citation

Review

Published on 15 Feb 2018

Engineered T Regulatory Type 1 Cells for Clinical Application

in Immunological Tolerance and Regulation

Silvia Gregori
Maria Grazia Roncarolo

Frontiers in Immunology

doi 10.3389/fimmu.2018.00233

21,749 views
66 citations

Original Research

Published on 17 Dec 2021

FoxP3− Tr1 Cell in Generalized Myasthenia Gravis and Its Relationship With the Anti-AChR Antibody and Immunomodulatory Cytokines

in Multiple Sclerosis and Neuroimmunology

Huanyu Meng
Shuyu Zheng
Qinming Zhou
Yining Gao
You Ni
Huafeng Liang
Sheng Chen

Frontiers in Neurology

doi 10.3389/fneur.2021.755356

4,272 views
6 citations

Review

Published on 29 Feb 2012

The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells

in T Cell Biology

Silvia Gregori
Kevin S. Goudy
Maria Grazia Roncarolo

Frontiers in Immunology

doi 10.3389/fimmu.2012.00030

30,071 views
149 citations

Original Research

Published on 07 Jul 2021

BHLHE40 Regulates IL-10 and IFN-γ Production in T Cells but Does Not Interfere With Human Type 1 Regulatory T Cell Differentiation

in T Cell Biology

Molly Javier Uyeda
Robert A. Freeborn
Brandon Cieniewicz
Rosa Romano
Ping (Pauline) Chen
Jeffrey Mao-Hwa Liu
Benjamin Thomas
Esmond Lee
Alma-Martina Cepika
Rosa Bacchetta

Frontiers in Immunology

doi 10.3389/fimmu.2021.683680

9,577 views
23 citations

Review

Published on 03 Aug 2022

Roles of type 1 regulatory T (Tr1) cells in allergen-specific immunotherapy

in Allergen Immunotherapy

Masaya Matsuda
Tetsuya Terada
Kazuyuki Kitatani
Ryo Kawata
Takeshi Nabe

Frontiers in Allergy

doi 10.3389/falgy.2022.981126

6,524 views
24 citations

Original Research

Published on 26 Feb 2019

Reversal of New Onset Type 1 Diabetes by Oral Salmonella-Based Combination Therapy and Mediated by Regulatory T-Cells in NOD Mice

in Immunological Tolerance and Regulation

Jacques C. Mbongue
Jeffrey Rawson
Pablo A. Garcia
Nelson Gonzalez
Jacob Cobb
Fouad Kandeel
Kevin Ferreri
Mohamed I. Husseiny

Frontiers in Immunology

doi 10.3389/fimmu.2019.00320

6,832 views
25 citations

Original Research

Published on 24 Feb 2025

BLIMP-1-dependent differentiation of T follicular helper cells into Foxp3+ T regulatory type 1 cells

in Immunological Tolerance and Regulation

Josep Garnica
Jun Yamanouchi
Robert Clarke
Joel Moro
Shari Thiessen
Javier Montaño
Debajyoti Mondal
Pau Serra
Pere Santamaria

Frontiers in Immunology

doi 10.3389/fimmu.2025.1519780

4,983 views
2 citations

Mini Review

Published on 25 Sep 2023

Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells

in T Cell Biology

Edgar Angelats
Pere Santamaria

Frontiers in Immunology

doi 10.3389/fimmu.2023.1267697

4,487 views
3 citations

Review

Published on 28 Oct 2022

Type 1 regulatory T cell-mediated tolerance in health and disease

in Immunological Tolerance and Regulation

Robert A. Freeborn
Steven Strubbe
Maria Grazia Roncarolo

Frontiers in Immunology

doi 10.3389/fimmu.2022.1032575

12,728 views
53 citations

Original Research

Published on 18 Jun 2025

Evaluating the immunogenicity of a mouse partial hindlimb for composite allotransplantation

in Alloimmunity and Transplantation

Jia Hui (Angela) Sun
Samantha Ligi
Felor Biniazan
Siba Haykal

Frontiers in Immunology

doi 10.3389/fimmu.2025.1595319

2,183 views

Original Research

Published on 24 Nov 2020

Vitamin D/CD46 Crosstalk in Human T Cells in Multiple Sclerosis

in Multiple Sclerosis and Neuroimmunology

Justin Killick
Joanne Hay
Elena Morandi
Sonja Vermeren
Saniya Kari
Thibault Angles
Anna Williams
Jan Damoiseaux
Anne L. Astier

Frontiers in Immunology

doi 10.3389/fimmu.2020.598727

8,160 views
15 citations

Articles

Highly purified and functionally stable in vitro expanded allospecific Tr1 cells expressing immunosuppressive graft-homing receptors as new candidates for cell therapy in solid organ transplantation

Tr1 Cells as a Key Regulator for Maintaining Immune Homeostasis in Transplantation

The Yin and Yang of Type 1 Regulatory T Cells: From Discovery to Clinical Application

Beyond Type 1 Regulatory T Cells: Co-expression of LAG3 and CD49b in IL-10-Producing T Cell Lineages

CD49b Targeting Inhibits Tumor Growth and Boosts Anti-tumor Immunity

Engineered T Regulatory Type 1 Cells for Clinical Application

FoxP3− Tr1 Cell in Generalized Myasthenia Gravis and Its Relationship With the Anti-AChR Antibody and Immunomodulatory Cytokines

The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells

BHLHE40 Regulates IL-10 and IFN-γ Production in T Cells but Does Not Interfere With Human Type 1 Regulatory T Cell Differentiation

Roles of type 1 regulatory T (Tr1) cells in allergen-specific immunotherapy

Reversal of New Onset Type 1 Diabetes by Oral Salmonella-Based Combination Therapy and Mediated by Regulatory T-Cells in NOD Mice

BLIMP-1-dependent differentiation of T follicular helper cells into Foxp3+ T regulatory type 1 cells

Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells

Type 1 regulatory T cell-mediated tolerance in health and disease

Evaluating the immunogenicity of a mouse partial hindlimb for composite allotransplantation

Vitamin D/CD46 Crosstalk in Human T Cells in Multiple Sclerosis