Trifunctional | List of Frontiers open access articles

Original Research

Published on 30 Apr 2025

Trifunctional antibody-cytokine fusion protein formats for tumor-targeted combination of IL-15 with IL-7 or IL-21

in Cancer Immunity and Immunotherapy

Annika M. Möller
Sarah Vettermann
Felix Baumann
Max Pütter
Dafne Müller

Frontiers in Immunology

doi 10.3389/fimmu.2025.1498697

4,068 views
4 citations

Original Research

Published on 14 May 2014

Controlling topological entanglement in engineered protein hydrogels with a variety of thiol coupling chemistries

in Chemical Biology

Shengchang Tang
Bradley D. Olsen

Frontiers in Chemistry

doi 10.3389/fchem.2014.00023

12,911 views
21 citations

Original Research

Published on 02 Mar 2021

Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation

in Chemical Biology

Mohadeseh Dastpeyman
John A. Karas
Azin Amin
Bradley J. Turner
Fazel Shabanpoor

Frontiers in Chemistry

doi 10.3389/fchem.2021.627329

7,722 views
14 citations

Original Research

Published on 09 Jun 2022

Silencing of Mitochondrial Trifunctional Protein A Subunit (HADHA) Increases Lipid Stores, and Reduces Oviposition and Flight Capacity in the Vector Insect Rhodnius prolixus

in Insect Physiology

Daniela S. Arêdes
Iron F. De Paula
Samara Santos-Araujo
Katia C. Gondim

Frontiers in Insect Science

doi 10.3389/finsc.2022.885172

3,490 views
21 citations

Original Research

Published on 23 Nov 2022

Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta gene as a tumour suppressor in stomach adenocarcinoma

in Gastrointestinal Cancers: Gastric and Esophageal Cancers

Yun Li
Jian-Bo Xiong
Zhi-Gang Jie
Hui Xiong

Frontiers in Oncology

doi 10.3389/fonc.2022.1069875

3,008 views
7 citations

Original Research

Published on 23 Feb 2023

Covalent adaptable networks using boronate linkages by incorporating TetraAzaADamantanes

in Supramolecular Chemistry

Simon van Hurne
Marijn Kisters
Maarten M. J. Smulders

Frontiers in Chemistry

doi 10.3389/fchem.2023.1148629

5,022 views
8 citations

Case Report

Published on 13 Jun 2023

Case report: Mitochondrial trifunctional protein deficiency caused by HADHB gene mutation (c.1175C>T) characterized by higher brain dysfunction followed by neuropathy, presented gadolinium enhancement on brain imaging in an adult patient

in Dementia and Neurodegenerative Diseases

Ruoyi Ishikawa
Masahiro Nakamori
Megumi Takenaka
Shiro Aoki
Yu Yamazaki
Akihiro Hashiguchi
Hiroshi Takashima
Hirofumi Maruyama

Frontiers in Neurology

doi 10.3389/fneur.2023.1187822

4,002 views
1 citation

Original Research

Published on 27 Jan 2021

Fermentative Production of l-2-Hydroxyglutarate by Engineered Corynebacterium glutamicum via Pathway Extension of l-Lysine Biosynthesis

in Industrial Biotechnology

Carina Prell
Arthur Burgardt
Florian Meyer
Volker F. Wendisch

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.630476

7,337 views
17 citations

Original Research

Published on 08 May 2019

Hierarchical Machine Learning Model for Mechanical Property Predictions of Polyurethane Elastomers From Small Datasets

in Computational Materials Science

Aditya Menon
James A. Thompson-Colón
Newell R. Washburn

Frontiers in Materials

doi 10.3389/fmats.2019.00087

14,607 views
35 citations

Original Research

Published on 15 Mar 2022

Dynamic Mitochondrial Proteome Under Polyamines Treatment in Cardiac Aging

in Stem Cell Research

Hao Zhang
Meng Yan
Ting Liu
Peiling Wei
Nannan Chai
Lingxu Li
Junying Wang
Xue Yu
Yan Lin
Bintao Qiu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2022.840389

6,481 views
13 citations

Brief Research Report

Published on 12 Oct 2021

Charcot–Marie–Tooth Disease With Episodic Rhabdomyolysis Due to Two Novel Mutations in the β Subunit of Mitochondrial Trifunctional Protein and Effective Response to Modified Diet Therapy

in Neuromuscular Disorders and Peripheral Neuropathies

Yuqing Guan
Yanxia Zhang
Xin-Ming Shen
Liang Zhou
Xuan Shang
Yu Peng
Yafang Hu
Wei Li

Frontiers in Neurology

doi 10.3389/fneur.2021.694966

6,328 views
3 citations

Review

Published on 27 Nov 2020

Recent Advances in the Pathophysiology of Fatty Acid Oxidation Defects: Secondary Alterations of Bioenergetics and Mitochondrial Calcium Homeostasis Caused by the Accumulating Fatty Acids

in Genetics of Common and Rare Diseases

Alexandre Umpierrez Amaral
Moacir Wajner

Frontiers in Genetics

doi 10.3389/fgene.2020.598976

11,253 views
20 citations

Original Research

Published on 04 Oct 2019

Systematic Dual Targeting of Dendritic Cell C-Type Lectin Receptor DC-SIGN and TLR7 Using a Trifunctional Mannosylated Antigen

in Chemical Biology

Rui-Jun Eveline Li
Tim P. Hogervorst
Silvia Achilli
Sven C. Bruijns
Tim Arnoldus
Corinne Vivès
Chung C. Wong
Michel Thépaut
Nico J. Meeuwenoord
Hans van den Elst

Frontiers in Chemistry

doi 10.3389/fchem.2019.00650

12,488 views
47 citations

Original Research

Published on 16 Apr 2025

Comparison of carbonic anhydrase-IX-targeted trifunctional radioligands between linear- and branched-chain arrangements

in Radiopharmacy and Radiochemistry

Kazuma Nakashima
Takayoshi Ichinose
Hiroyuki Watanabe
Masahiro Ono

Frontiers in Nuclear Medicine

doi 10.3389/fnume.2025.1585027

2,736 views
1 citation

Original Research

Published on 22 Jun 2023

Characteristics of Mycobacterium tuberculosis PtpA interaction and activity on the alpha subunit of human mitochondrial trifunctional protein, a key enzyme of lipid metabolism

in Bacteria and Host

Mariana Margenat
Gabriela Betancour
Vivian Irving
Alicia Costábile
Tania García-Cedrés
María Magdalena Portela
Federico Carrión
Fernando E. Herrera
Andrea Villarino

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2023.1095060

5,291 views
7 citations

Systematic Review

Published on 19 Mar 2021

Newborn Screening for Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase and Mitochondrial Trifunctional Protein Deficiencies Using Acylcarnitines Measurement in Dried Blood Spots—A Systematic Review of Test Accuracy

in Neonatology

Chris Stinton
Hannah Fraser
Julia Geppert
Rebecca Johnson
Martin Connock
Samantha Johnson
Aileen Clarke
Sian Taylor-Phillips

Frontiers in Pediatrics

doi 10.3389/fped.2021.606194

7,550 views
12 citations

Articles

Trifunctional antibody-cytokine fusion protein formats for tumor-targeted combination of IL-15 with IL-7 or IL-21

Controlling topological entanglement in engineered protein hydrogels with a variety of thiol coupling chemistries

Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation

Silencing of Mitochondrial Trifunctional Protein A Subunit (HADHA) Increases Lipid Stores, and Reduces Oviposition and Flight Capacity in the Vector Insect Rhodnius prolixus

Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta gene as a tumour suppressor in stomach adenocarcinoma

Covalent adaptable networks using boronate linkages by incorporating TetraAzaADamantanes

Case report: Mitochondrial trifunctional protein deficiency caused by HADHB gene mutation (c.1175C>T) characterized by higher brain dysfunction followed by neuropathy, presented gadolinium enhancement on brain imaging in an adult patient

Fermentative Production of l-2-Hydroxyglutarate by Engineered Corynebacterium glutamicum via Pathway Extension of l-Lysine Biosynthesis

Hierarchical Machine Learning Model for Mechanical Property Predictions of Polyurethane Elastomers From Small Datasets

Dynamic Mitochondrial Proteome Under Polyamines Treatment in Cardiac Aging

Charcot–Marie–Tooth Disease With Episodic Rhabdomyolysis Due to Two Novel Mutations in the β Subunit of Mitochondrial Trifunctional Protein and Effective Response to Modified Diet Therapy

Recent Advances in the Pathophysiology of Fatty Acid Oxidation Defects: Secondary Alterations of Bioenergetics and Mitochondrial Calcium Homeostasis Caused by the Accumulating Fatty Acids

Systematic Dual Targeting of Dendritic Cell C-Type Lectin Receptor DC-SIGN and TLR7 Using a Trifunctional Mannosylated Antigen

Comparison of carbonic anhydrase-IX-targeted trifunctional radioligands between linear- and branched-chain arrangements

Characteristics of Mycobacterium tuberculosis PtpA interaction and activity on the alpha subunit of human mitochondrial trifunctional protein, a key enzyme of lipid metabolism

Newborn Screening for Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase and Mitochondrial Trifunctional Protein Deficiencies Using Acylcarnitines Measurement in Dried Blood Spots—A Systematic Review of Test Accuracy