Tumor Suppressor Protein | List of Frontiers open access articles

Original Research

Published on 05 Nov 2019

TRIM8 Blunts the Pro-proliferative Action of ΔNp63α in a p53 Wild-Type Background

in Molecular and Cellular Oncology

Mariano Francesco Caratozzolo
Flaviana Marzano
Daniela Isabel Abbrescia
Francesca Mastropasqua
Vittoria Petruzzella
Viola Calabrò
Graziano Pesole
Elisabetta Sbisà
Luisa Guerrini
Apollonia Tullo

Frontiers in Oncology

doi 10.3389/fonc.2019.01154

4,895 views
11 citations

Review

Published on 26 Jan 2022

p53 Modulation of Autophagy Signaling in Cancer Therapies: Perspectives Mechanism and Therapeutic Targets

in Molecular and Cellular Oncology

Md Ataur Rahman
Moon Nyeo Park
MD Hasanur Rahman
Md Mamunur Rashid
Rokibul Islam
Md Jamal Uddin
Md Abdul Hannan
Bonglee Kim

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2022.761080

14,063 views
75 citations

Original Research

Published on 25 Jul 2012

The splicing mutant of the human tumor suppressor protein DFNA5 induces programmed cell death when expressed in the yeast Saccharomyces cerevisiae

in Molecular and Cellular Oncology

Sofie Van Rossom
Ken Op de Beeck
Vanessa Franssens
Erwin Swinnen
Anne Schepers
Ruben Ghillebert
Marina Caldara
Guy Van Camp
Joris Winderickx

Frontiers in Oncology

doi 10.3389/fonc.2012.00077

9,654 views
42 citations

Perspective

Published on 22 Jul 2014

ARF: a versatile DNA damage response ally at the crossroads of development and tumorigenesis

in Cancer Genetics

Athanassios Kotsinas
Panagiota Papanagnou
Konstantinos Evangelou
George C. Trigas
Vassiliki Kostourou
Paul Townsend
Vassilis G. Gorgoulis

Frontiers in Genetics

doi 10.3389/fgene.2014.00236

7,061 views
14 citations

Review

Published on 31 Mar 2021

Exploring the Roles of HERC2 and the NEDD4L HECT E3 Ubiquitin Ligase Subfamily in p53 Signaling and the DNA Damage Response

in Cancer Molecular Targets and Therapeutics

Nicholas A. Mathieu
Rafael H. Levin
Donald E. Spratt

Frontiers in Oncology

doi 10.3389/fonc.2021.659049

9,649 views
16 citations

Review

Published on 19 Sep 2023

The roles of protein ubiquitination in tumorigenesis and targeted drug discovery in lung cancer

in Cancer Endocrinology

Zhen Ye
Jingru Yang
Hanming Jiang
Xianquan Zhan

Frontiers in Endocrinology

doi 10.3389/fendo.2023.1220108

11,004 views
16 citations

Review

Published on 02 Apr 2020

Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet?

in Molecular and Cellular Oncology

Si-Min Qi
Gang Cheng
Xiang-Dong Cheng
Zhiyuan Xu
Beihua Xu
Wei-Dong Zhang
Jiang-Jiang Qin

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2020.00233

23,375 views
126 citations

Mini Review

Published on 30 Aug 2018

Cancerous Protein Network That Inhibits the Tumor Suppressor Function of WW Domain-Containing Oxidoreductase (WWOX) by Aberrantly Expressed Molecules

in Molecular and Cellular Oncology

Chiemi Saigo
Yusuke Kito
Tamotsu Takeuchi

Frontiers in Oncology

doi 10.3389/fonc.2018.00350

4,269 views
16 citations

Review

Published on 21 Dec 2022

The function of p53 and its role in Alzheimer’s and Parkinson’s disease compared to age-related macular degeneration

in Neurodegeneration

Peter Wolfrum
Agnes Fietz
Sven Schnichels
José Hurst

Frontiers in Neuroscience

doi 10.3389/fnins.2022.1029473

10,166 views
39 citations

Mini Review

Published on 27 Apr 2023

An anti-cancer surveillance by the interplay between interferon-beta and retinoblastoma protein RB1

in Molecular and Cellular Oncology

Albert Qin

Frontiers in Oncology

doi 10.3389/fonc.2023.1173467

4,492 views
24 citations

Mini Review

Published on 09 Aug 2019

Reciprocal Crosstalk Between YAP1/Hippo Pathway and the p53 Family Proteins: Mechanisms and Outcomes in Cancer

in Signaling

Nitin Raj
Rakesh Bam

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2019.00159

19,536 views
87 citations

Original Research

Published on 26 Apr 2023

Amomum subulatum: A treasure trove of anti-cancer compounds targeting TP53 protein using in vitro and in silico techniques

in Medicinal and Pharmaceutical Chemistry

Sadaqat Ali
Asifa Noreen
Adeem Qamar
Imran Zafar
Quratul Ain
Hiba-Allah Nafidi
Yousef A. Bin Jardan
Mohammed Bourhia
Summya Rashid
Rohit Sharma

Frontiers in Chemistry

doi 10.3389/fchem.2023.1174363

7,161 views
24 citations

Mini Review

Published on 15 Mar 2023

Tenascin-X as a causal gene for classical-like Ehlers-Danlos syndrome

in Genetics of Common and Rare Diseases

Emiko Okuda-Ashitaka
Ken-ichi Matsumoto

Frontiers in Genetics

doi 10.3389/fgene.2023.1107787

17,819 views
19 citations

Original Research

Published on 15 Aug 2024

FGF21 upregulation by hepatitis C virus via the eIF2α-ATF4 pathway: implications for interferon signaling suppression and TRIM31-mediated TSC degradation

in Virology

Liang Liu
Masahiko Ito
Satoshi Sakai
Jie Liu
Kazuyoshi Ohta
Kenji Saito
Kenji Nakashima
Shinya Satoh
Alu Konno
Tetsuro Suzuki

Frontiers in Microbiology

doi 10.3389/fmicb.2024.1456108

3,191 views
2 citations

Brief Research Report

Published on 03 Mar 2021

Canine Papillomavirus 2 E6 Does Not Interfere With UVB-Induced Upregulation of p53 and p53-Regulated Genes

in Comparative and Clinical Medicine

Sarah Quinlan
Susan May
Ryan Weeks
Hang Yuan
Jennifer Luff

Frontiers in Veterinary Science

doi 10.3389/fvets.2021.570982

3,381 views
5 citations

Review

Published on 26 Sep 2022

Recent findings on the role of wild-type and mutant p53 in cancer development and therapy

in Cellular Biochemistry

Mehregan Babamohamadi
Esmaeil Babaei
Burhan Ahmed Salih
Mahshid Babamohammadi
Hewa Jalal Azeez
Goran Othman

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.903075

29,351 views
31 citations

Articles

TRIM8 Blunts the Pro-proliferative Action of ΔNp63α in a p53 Wild-Type Background

p53 Modulation of Autophagy Signaling in Cancer Therapies: Perspectives Mechanism and Therapeutic Targets

The splicing mutant of the human tumor suppressor protein DFNA5 induces programmed cell death when expressed in the yeast Saccharomyces cerevisiae

ARF: a versatile DNA damage response ally at the crossroads of development and tumorigenesis

Exploring the Roles of HERC2 and the NEDD4L HECT E3 Ubiquitin Ligase Subfamily in p53 Signaling and the DNA Damage Response

The roles of protein ubiquitination in tumorigenesis and targeted drug discovery in lung cancer

Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet?

Cancerous Protein Network That Inhibits the Tumor Suppressor Function of WW Domain-Containing Oxidoreductase (WWOX) by Aberrantly Expressed Molecules

The function of p53 and its role in Alzheimer’s and Parkinson’s disease compared to age-related macular degeneration

An anti-cancer surveillance by the interplay between interferon-beta and retinoblastoma protein RB1

Reciprocal Crosstalk Between YAP1/Hippo Pathway and the p53 Family Proteins: Mechanisms and Outcomes in Cancer

Amomum subulatum: A treasure trove of anti-cancer compounds targeting TP53 protein using in vitro and in silico techniques

Tenascin-X as a causal gene for classical-like Ehlers-Danlos syndrome

FGF21 upregulation by hepatitis C virus via the eIF2α-ATF4 pathway: implications for interferon signaling suppression and TRIM31-mediated TSC degradation

Canine Papillomavirus 2 E6 Does Not Interfere With UVB-Induced Upregulation of p53 and p53-Regulated Genes

Recent findings on the role of wild-type and mutant p53 in cancer development and therapy