Systems Biology

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Systems Biology

Systems biology investigates complex biological interactions through integrative approaches. Our Research Topics bring together experimental and computational methods to model cellular networks, signaling pathways, and dynamic systems. By uncovering how biological components interact, we aim to support discoveries that improve prediction, intervention, and understanding across the life sciences.

The following Research Topics are led by experts in their field and contribute to the scientific understanding of systems biology. These Research topics are published in the peer-reviewed journal Frontiers in Systems Biology, as open access articles.

Research Topics

Frontiers' Research Topics are peer-reviewed article collections around cutting-edge research themes.
Learn more about how Research topics work.

3D illustration. Concept of artificial neuron. The dendrite of an axon, slender projection of a nerve cell.

Advancing Biology and Medicine through Systems Thinking and Artificial Intelligence / Machine Learning Technologies

This Research Topic aims to explore and emphasize the use and impact of systems thinking in the integration of advanced technologies like AI/ML within the fields of biology and medicine.

Medically 3D illustration showing right kidney, x-ray style, cross section

Integrating Bioinformatics and AI to Unravel Multi-Organ Dynamics and Therapeutic Avenues in Renal Diseases

This Research Topic aims to integrate computational advancements with biological research to illuminate the dynamics of multi-organ interactions in renal disease.

Scientist pipetting sample into a vial for DNA testing

iGEM 2025/2026: Systems Biology in Biomedical Innovations and Healthcare

This Research Topic aims to spotlight the multifaceted applications of Systems Biology as a foundational and translational tool for biomedical innovation.

Beautiful Pilchowickie lake and the dam at sunset, Lower Silesia. Poland

iGEM 2025/2026: Systems Biology & Synthetic Approaches in Achieving Sustainable Action

This Research Topic aims to showcase novel strategies that utilize Systems Biology and Synthetic Biology as effective tools for sustainable development.

Colorful chain of amino acids or bio molecules called proteins - 3d illustration

iGEM 2025/2026: Systems and Synthetic Biology in Healthcare and Pandemic Preparedness

This Research Topic aims to explore how synthetic and systems biology are being applied to improve pandemic readiness and infectious disease control.

Biofilm of antibiotic resistant bacteria, closeup view. Rod-shaped and spherical bacteria. Escherichia coli, Pseudomonas aeruginosa, Mycobacterium tuberculosis, Klebsiella, Staphylococcus aureus, MRSA

Decoding the Antibiotic Resistance Puzzle: Unleashing the Power of Computational Analysis and Dynamic Tracking in Microbial (Meta)Genomics and Phenomics

This Research Topic aims to bring together researchers and experts to unravel the complexities of antibiotic resistance by harnessing the power of computational analysis and dynamic tracking in microbial (meta)genomics and/or phenomics.

Futuristic data stream 3d illustration. Data transfer technology. Cyberpunk, Big data and cybersecurity. Cyberspace, blockchain transactions. Abstract technological background

iGEM 2025/2026: Technological Advancements in Engineering: From Production to AI and Software

This Research Topic aims to spotlight the multifaceted applications of Systems Biology, Synthetic Biology, and Bioinformatics at the intersection of technological advancements.

3D rendering of Tumor Microenvironment

Small Moves, Big Impact: Exploring Partial Tumor Phenotype Reversal via Limited Gene Modulation

Background: The transformation from a normal tissue to a tumor is marked by a dramatic upheaval in gene expression, with thousands of genes showing altered expression patterns during this spontaneous transition.

Close up of female student writing an equation on white board in classroom. Girl writing on board during maths class.

United States Biomedical Science Policy: Success, Failure & Recommendation: Past, Present & Future

This Topic focuses on the evaluation of past and current biomedical science policies in the US, including their global impact and alternatives, along with recommendations for evidence-based future policy recommendations.

Two neuron and sinapse, sending electrical and chemical signals. 3d rendering

Systems Modelling of the Central Nervous System; understanding the building blocks of complex systems

This research topic aims to explore the intricate and multifaceted nature of the central nervous system (CNS) through the lens of systems biology.

Big Data in Systems Biology

This Research Topic aims to encourage a collaborative discussion on overcoming key challenges in analyzing multiple outcomes and deriving robust inferences from diverse data sources like multi-omics, single-cell omics, and multi-modal imaging.

3D illustration. Concept of artificial neuron. The dendrite of an axon, slender projection of a nerve cell.

Advancing Biology and Medicine through Systems Thinking and Artificial Intelligence / Machine Learning Technologies

This Research Topic aims to explore and emphasize the use and impact of systems thinking in the integration of advanced technologies like AI/ML within the fields of biology and medicine.

Medically 3D illustration showing right kidney, x-ray style, cross section

Integrating Bioinformatics and AI to Unravel Multi-Organ Dynamics and Therapeutic Avenues in Renal Diseases

This Research Topic aims to integrate computational advancements with biological research to illuminate the dynamics of multi-organ interactions in renal disease.

Scientist pipetting sample into a vial for DNA testing

iGEM 2025/2026: Systems Biology in Biomedical Innovations and Healthcare

This Research Topic aims to spotlight the multifaceted applications of Systems Biology as a foundational and translational tool for biomedical innovation.

Beautiful Pilchowickie lake and the dam at sunset, Lower Silesia. Poland

iGEM 2025/2026: Systems Biology & Synthetic Approaches in Achieving Sustainable Action

This Research Topic aims to showcase novel strategies that utilize Systems Biology and Synthetic Biology as effective tools for sustainable development.

Colorful chain of amino acids or bio molecules called proteins - 3d illustration

iGEM 2025/2026: Systems and Synthetic Biology in Healthcare and Pandemic Preparedness

This Research Topic aims to explore how synthetic and systems biology are being applied to improve pandemic readiness and infectious disease control.

Biofilm of antibiotic resistant bacteria, closeup view. Rod-shaped and spherical bacteria. Escherichia coli, Pseudomonas aeruginosa, Mycobacterium tuberculosis, Klebsiella, Staphylococcus aureus, MRSA

Decoding the Antibiotic Resistance Puzzle: Unleashing the Power of Computational Analysis and Dynamic Tracking in Microbial (Meta)Genomics and Phenomics

This Research Topic aims to bring together researchers and experts to unravel the complexities of antibiotic resistance by harnessing the power of computational analysis and dynamic tracking in microbial (meta)genomics and/or phenomics.

Futuristic data stream 3d illustration. Data transfer technology. Cyberpunk, Big data and cybersecurity. Cyberspace, blockchain transactions. Abstract technological background

iGEM 2025/2026: Technological Advancements in Engineering: From Production to AI and Software

This Research Topic aims to spotlight the multifaceted applications of Systems Biology, Synthetic Biology, and Bioinformatics at the intersection of technological advancements.

3D rendering of Tumor Microenvironment

Small Moves, Big Impact: Exploring Partial Tumor Phenotype Reversal via Limited Gene Modulation

Background: The transformation from a normal tissue to a tumor is marked by a dramatic upheaval in gene expression, with thousands of genes showing altered expression patterns during this spontaneous transition.

Close up of female student writing an equation on white board in classroom. Girl writing on board during maths class.

United States Biomedical Science Policy: Success, Failure & Recommendation: Past, Present & Future

This Topic focuses on the evaluation of past and current biomedical science policies in the US, including their global impact and alternatives, along with recommendations for evidence-based future policy recommendations.

Two neuron and sinapse, sending electrical and chemical signals. 3d rendering

Systems Modelling of the Central Nervous System; understanding the building blocks of complex systems

This research topic aims to explore the intricate and multifaceted nature of the central nervous system (CNS) through the lens of systems biology.

Big Data in Systems Biology

This Research Topic aims to encourage a collaborative discussion on overcoming key challenges in analyzing multiple outcomes and deriving robust inferences from diverse data sources like multi-omics, single-cell omics, and multi-modal imaging.