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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Genet. | doi: 10.3389/fgene.2018.00598

Shared Gene Expression between Multiple Sclerosis and Ischemic Stroke.

  • 1Tianjin Medical University General Hospital, China
  • 2Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in Central Nervous System, General Hospital of Tianjin Medical University, China

Patients with multiple sclerosis (MS) appear to have an increased risk of ischemic stroke (IS). Although MS and IS have very different phenotypes, gene-based and pathway-based analyses of large-scale genome-wide association studies (GWAS) have increasingly enhanced our understanding of these two diseases. Whether there are common molecular mechanisms connecting MS and IS is still unclear. Here, we describe the outcome of gene-based test, and pathway-based analysis of GWAS datasets that explored potential gene expression links between MS and IS. After identifying significant gene sets individually of MS and IS, we performed pathway-based analysis in four biological pathway databases (KEGG, PANTHER, REACTOME, and WikiPathways) and GO categories. We discovered that there were 9 shared pathways between MS and IS in KEGG, 2 in PANTHER, 14 in REACTOME, 1 in WikiPathways, and 194 in GO annotations (p < 0.05). These results provide an improved understanding about possible shared mechanisms and treatments strategies for MS and IS. They also provide some basis for further studies of how these two diseases are linked at the molecular level.

Keywords: Genome-wide association studies (GWAS), Multiple Sclerosis, ischemic stroke, Gene-based test, pathway-based analysis, histocompatibility complex variants, Single nucleotide polymorphism

Received: 10 Sep 2018; Accepted: 15 Nov 2018.

Edited by:

Yan Huang, Harvard Medical School, United States

Reviewed by:

Claudia V. Maurer-Morelli, Universidade Estadual de Campinas, Brazil
Subhabrata Sanyal, California Life Company (Calico), United States  

Copyright: © 2018 Li, Ma, Cui, Lang and Hao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: MD, PhD. Junwei Hao, Tianjin Medical University General Hospital, Tianjin, China, hjw@tmu.edu.cn