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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Genet. | doi: 10.3389/fgene.2019.00506

LINC00673 rs11655237 C>T polymorphism impacts hepatoblastoma susceptibility in Chinese children

Tianyou Yang1, 2, Jiahao Li1, Yang Wen3, Tianbao Tan1, Jiliang Yang1,  Jing Pan1, Chao Hu1, Yuxiao Yao1, Jiao Zhang4, Yijuan Xin5, Suhong Li6,  Huimin Xia1, 2,  Jing He1, 2* and  Yan Zou1, 2*
  • 1Guangzhou Women and Children's Medical Center, China
  • 2Guangzhou Medical University, China
  • 3First Affiliated Hospital of Sun Yat-sen University, China
  • 4First Affiliated Hospital of Zhengzhou University, China
  • 5Xijing Hospital, Fourth Military Medical University, China
  • 6Department of Pathology, Shanxi Provincial Maternal and Child Health Hospital, China

Background: Hepatoblastoma (HB) is the most common hepatic malignancy in children, accounting for approximately 80% of all childhood liver tumors. Previous genome-wide association studies (GWASs) have found that the LINC00673 rs11655237 C>T polymorphism is associated with the risk of several different adult cancers. However, the association between this polymorphism and HB susceptibility remains unclear.
Methods: We analyzed the association between the LINC00673 rs11655237 C>T polymorphism and HB susceptibility in a hospital-based study of Chinese children. We enrolled 213 HB patients and 958 healthy controls with genotypes determined by TaqMan, and the strength of the association of interest was determined by calculating odds ratios (ORs) and 95% confidence intervals (CIs).
Findings: We found a significant association between the LINC00673 rs11655237 C>T polymorphism and HB risk (CT/TT compared with CC: adjusted OR=1·40, 95% CI=1·04–1·88, p=0·029). Furthermore, stratified analysis indicated that rs11655237 T allele carriers in the following subgroups were more likely to develop HB: children older than 17 months, males, and those with tumors of clinical stages III + IV.
Interpretation: In conclusion, we confirmed that the LINC00673 rs11655237 C>T polymorphism may be associated with HB susceptibility. Prospective studies with larger sample sizes and patients of different ethnicities are needed to validate our findings.

Keywords: Hepatoblastoma, cancer susceptibility, linc00673, genetic association analysis, Liver malignancy

Received: 31 Jan 2019; Accepted: 07 May 2019.

Edited by:

Ihab Younis, Carnegie Mellon University in Qatar, Qatar

Reviewed by:

Tania L. Slatter, University of Otago, New Zealand
Maria Gazouli, National and Kapodistrian University of Athens, Greece  

Copyright: © 2019 Yang, Li, Wen, Tan, Yang, Pan, Hu, Yao, Zhang, Xin, Li, Xia, He and Zou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
PhD. Jing He, Guangzhou Women and Children's Medical Center, Guangzhou, 510623, China, hejing198374@gmail.com
Dr. Yan Zou, Guangzhou Women and Children's Medical Center, Guangzhou, 510623, China, 378319696@qq.com