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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Genet. | doi: 10.3389/fgene.2019.00696

Host Genetic Determinants of Hepatitis B Virus Infection

Zhenhua Zhang1, Changtai Wang1*, Zhongping Liu1, Guizhou Zou1,  Jun Li1 and  Mengji Lu2*
  • 1Anhui Medical University, China
  • 2Essen University Hospital, Germany

Chronic hepatitis B virus (HBV) infection is still a major health problem worldwide. Recently, a great number of genetic studies based on single nucleotide polymorphisms (SNPs) and genome-wide association studies have been performed to search for host determinants of the development of chronic HBV infection, clinical outcomes, therapeutic efficacy, and responses to hepatitis B vaccines, with a focus on human leukocyte antigens (HLA), cytokine genes, and toll-like receptors. In addition to SNPs, gene insertions/deletions and copy number variants are associated with infection. However, conflicting results have been obtained. In the present review, we summarize the current state of research on host genetic factors and chronic HBV infection, its clinical type, therapies, and hepatitis B vaccine responses, and classified published results according to their reliability. The potential roles of host genetic determinants of chronic HBV infection identified in these studies and their clinical significance are discussed. In particular, HLAs were relevant for HBV infection and pathogenesis. Finally, we highlight the need for additional studies with large sample sizes, well-matched study designs, appropriate statistical methods, and validation in multiple populations to improve the treatment of HBV infection.

Keywords: Hepatitis B virus, genetic determinants, human leukocyte antigen, susceptibility gene, Single nucleotide polymorphism, Genome-Wide Association Study

Received: 07 Nov 2018; Accepted: 03 Jul 2019.

Edited by:

Cheryl A. Winkler, Frederick National Laboratory for Cancer Research (NIH), United States

Reviewed by:

Michael Scheurer, Baylor College of Medicine, United States
Guangwen Cao, Second Military Medical University, China  

Copyright: © 2019 Zhang, Wang, Liu, Zou, Li and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
MD. Changtai Wang, Anhui Medical University, Hefei, 230032, Anhui Province, China, 543531700@qq.com
Prof. Mengji Lu, Essen University Hospital, Essen, Germany, mengji.lu@uni-due.de