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Front. Genet. | doi: 10.3389/fgene.2019.00764

The Impact of One Carbon Metabolism on Histone Methylation

  • 1Ludwig Maximilian University of Munich, Germany
  • 2BioMedizinisches Zentrum, Ludwig-Maximilians, Universität München, Germany
  • 3Biomedical Center Munich Molecular Biology, Imhof lab, Ludwig Maximilian University of Munich, Germany

The effect of one carbon metabolism on DNA methylation has been well described, bridging nutrition, metabolism, and epigenetics. This modification is mediated by the metabolite S-Adenosyl Methionine (SAM), which is also the methyl-donating substrate of histone methyltransferases. Therefore, SAM levels that are influenced by several nutrients, enzymes, and metabolic co-factors also have a potential impact on histone methylation. Although, this modification plays a major role in chromatin accessibility and subsequently in gene expression in healthy or diseased states, its role in translating nutritional changes in chromatin structure has not been extensively studied. Here, we aim to review the literature of known mechanistic links between histone methylation and the central one carbon metabolism.

Keywords: Folate, S-Adenosylmethionine, Histone methlyation, One-carbon metabolism, Methioine

Received: 17 Mar 2019; Accepted: 18 Jul 2019.

Copyright: © 2019 Serefidou, Venkatasubramani and Imhof. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Ms. Magdalini Serefidou, Ludwig Maximilian University of Munich, Munich, Germany,