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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Genet. | doi: 10.3389/fgene.2019.00803

Comprehensive analysis of therapy-related mRNAs and lncRNAs as novel biomarkers for advanced colorectal cancer

Jibin Li1, Siping Ma2, Tao Lin2, Yanxi Li2, Shihua Yang3,  Wanchuan Zhang3, Rui Zhang2 and  Yongpeng Wang2*
  • 1Liaoning Cancer Hospital, Cancer Hospital of China Medical University, China
  • 2Liaoning Cancer Hospital, Cancer Hospital of China Medical University, China
  • 3China Medical University, China

Colorectal cancer (CRC) is one of the most common types of human cancers. However, the mechanisms underlying CRC progression remained elusive. This study identified differently expressed mRNAs, lncRNAs and snoRNAs between pre-therapeutic biopsies and post-therapeutic resections of locally advanced colorectal cancer by analyzing a public dataset, GSE94104. We identified 427 dysregulated mRNAs, 4 dysregulated lncRNAs and 19 dysregulated snoRNAs between pre- and post-therapeutic locally advanced colorectal cancer samples. By constructing PPI network and co-expressing networks, we identified 10 key mRNAs, 4 key lncRNAs and 7 key snoRNAs. Bioinformatics analysis showed therapy related mRNAs were associated with nucleosome assembly, chromatin silencing at rDNA, negative regulation of gene expression, DNA replication. therapy related lncRNAs were associated with cell adhesion, extracellular matrix organization, angiogenesis, sister chromatid cohesion. And therapy related snoRNAs were associated with DNA replication, nucleosome assembly, telomere organization. We thought this study provided useful information for identifying novel biomarkers for CRC.

Keywords: long non-coding RNA, snoRNAs, Prognostic Markers, expression profiling, Protein-protein interaction analysis, Co-expression analysis, colorectal cancer

Received: 07 May 2019; Accepted: 31 Jul 2019.

Copyright: © 2019 Li, Ma, Lin, Li, Yang, Zhang, Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Yongpeng Wang, Liaoning Cancer Hospital, Cancer Hospital of China Medical University, Shenyang, 110042, Liaoning Province, China, puhao9502147@163.com