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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Genet. | doi: 10.3389/fgene.2019.01017

From Genetics to Epigenetics, Roles of Epigenetics in Inflammatory Bowel Disease

  • 1Department of Gastroenterology, West China Hospital, Sichuan University, China
  • 2Center for Inflammatory Bowel Disease, West China Hospital, Sichuan University, China
  • 3Clinical Medicine, West China Medical Center, Sichuan Medical University, China

Inflammatory bowel disease (IBD) is a destructive, recurrent, and heterogeneous disease. Its detailed pathogenesis is still unclear, although available evidence supports that IBD is caused by a complex interplay between genetic predispositions, environmental factors, and aberrant immune responses. Recent breakthroughs with regard to its genetics have offered valuable insights into the sophisticated genetic basis, but the identified genetic factors only explain a small part of overall disease variance. It is becoming increasingly apparent that epigenetic factors can mediate the interaction between genetics and environment, and play a fundamental role in the pathogenesis of IBD. This review outlines recent genetic and epigenetic discoveries in IBD, with a focus on the roles of epigenetics in disease susceptibility, activity, behavior and colorectal cancer (CRC), and their potential translational applications.

Keywords: epigenetic modifications, inflammatory bowel disease, Disease Susceptibility, disease activity, Disease behavior, colorectal cancer, therapeutic translation

Received: 12 May 2019; Accepted: 24 Sep 2019.

Copyright: © 2019 Zhang, Zeng and Mukherjee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Hu Zhang, Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China, zhanghu@scu.edu.cn