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ORIGINAL RESEARCH article

Front. Gastroenterol.
Sec. Therapy in Gastroenterology
Volume 3 - 2024 | doi: 10.3389/fgstr.2024.1382348

Response rate to the treatment of achalasia in Iranian patients with thyroid disorders versus euthyroid patients: A cross sectional study

Provisionally accepted
Alireza Mehrban Alireza Mehrban 1Mehdi Karimi Mehdi Karimi 2*Fatemeh Ahmadi Hajikolaei Fatemeh Ahmadi Hajikolaei 3Mohammad S. Saghafi Mohammad S. Saghafi 4Pegah Refahi Pegah Refahi 5*Amir Anoushirvani Amir Anoushirvani 1*Aydin Hassanpour Adeh Aydin Hassanpour Adeh 6Javad Mikaeli Javad Mikaeli 1*
  • 1 Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Alborz, Iran
  • 2 Bogomolets National Medical University, Kyiv, Ukraine
  • 3 Babol University of Medical Sciences, Babol, Mazandaran, Iran
  • 4 Qom University of Medical Sciences, Qom, Qom, Iran
  • 5 Mashhad University of Medical Sciences, Mashhad, Razavi Khorasan, Iran
  • 6 Islamic Azad University, Tabriz, Tabriz, Iran

The final, formatted version of the article will be published soon.

    Background: Achalasia stems from the progressive depletion of ganglion cells in the myenteric plexus situated in the esophageal wall. Moreover, the association between achalasia and thyroid disorders, such as hypothyroidism, Hashimoto's, and Graves' disease, remains a subject of debate, with the origins of autoimmune disorders linked to achalasia and their interconnection currently not fully understood. This study was conducted for the first time with the aim of investigating and comparing the response rate to treatment in achalasia patients with and without thyroid disorders.In this retrospective cross-sectional investigation, a total of 393 participants, comprising 216 women and 177 men, were included. All subjects were monitored for a minimum of six months and categorized into two groups. Variables such as age, gender, history of thyroid disease and associated symptoms, past occurrences of other autoimmune diseases, the quantity of achalasia treatments administered, assessment of the severity of achalasia symptoms at each treatment stage, and the outcomes of thyroid tests (TSH, Anti-TPO) were extracted from the participants' records.Results: In this study, no statistically significant correlation was identified between the response to achalasia treatment in euthyroid patients and those with thyroid disorders (P = 0.176). Among all participants, 292 individuals (74.3%) underwent Anti-TPO testing, revealing that 60 patients (20.5%) had autoimmune thyroiditis. The analysis indicated a noteworthy association between autoimmune thyroiditis and the age of the patients (P = 0.024). However, no significant correlation was observed between the treatment response of achalasia patients in the two groups-those with and without thyroid autoimmune disorders (P = 0.13).Achalasia is probably associated with various types of autoimmune thyroid diseases (hyperthyroidism, hypothyroidism and thyroid nodular diseases).

    Keywords: Achalasia, thyroid disorders, autoimmune thyroiditis, Euthyroid, Esophageal Motility Disorders

    Received: 05 Feb 2024; Accepted: 10 Apr 2024.

    Copyright: © 2024 Mehrban, Karimi, Ahmadi Hajikolaei, Saghafi, Refahi, Anoushirvani, Hassanpour Adeh and Mikaeli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Mehdi Karimi, Bogomolets National Medical University, Kyiv, 01601, Ukraine
    Pegah Refahi, Mashhad University of Medical Sciences, Mashhad, 91778 9919, Razavi Khorasan, Iran
    Amir Anoushirvani, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Alborz, Iran
    Javad Mikaeli, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Alborz, Iran

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