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Front. Med. | doi: 10.3389/fmed.2018.00036

Feasibility of systematic respiratory-gated acquisition in unselected patients referred for 18F-FDG PET/CT.

  • 1Service de Médecine Nucléaire,, Centre Hospitalier Regional Universitaire (CHU) de Brest, France

Objective
Respiratory motion in FDG-PET/CT induces blurred images, leading to errors in location and quantification for lung and abdominal lesions. Various methods have been developed to correct for these artefacts, and most of current PET/CT scanners are equipped with a respiratory gating system. However, they are not routinely performed because their use is time-consuming. The aim of this study is to assess the feasibility and quantitative impact of a systematic respiratory-gated acquisition in unselected patients referred for FDG-PET/CT, without increasing acquisition time.

Methods
Patients referred for a FDG-PET/CT examination to the nuclear medicine department of Brest University Hospital were consecutively enrolled, during a 3 month-period. Cases presenting lung or liver uptakes were analysed. Two sets of images were reconstructed from data recorded during a unique acquisition with a continuous table speed of 1mm/s of the used Biograph mCT Flow PET/CT scanner: standard free-breathing images, and respiratory-gated images. Lesion location and quantitative parameters were recorded and compared.

Results
From October 1st 2015 to December 31st 2015, 847 patients were referred for FDG-PET/CT, 741 underwent a respiratory-gated acquisition. Out of them, 213 (29%) had one or more lung or liver uptake but 82 (38%) had no usable respiratory-gated signal. Accordingly, 131 (62%) patients with 183 lung or liver uptakes were analysed. Considering the 183 lesions, 140 and 43 were located in the lungs and the liver respectively. The median (IQR) difference between respiratory-gated images and non-gated images was 18% (-4 − 32) for SUV max, increasing to 30% (14 − 57) in lower lobes for lung lesions, and - 18% (-40 − -4) for MTV (p<0.05). Technologists’ active personal dosimetry and mean total examinations duration were not statistically different between periods with and without respiratory gating.

Conclusion
This study showed that a systematic respiratory-gated acquisition without increasing acquisition time is feasible in a daily routine and results in a significant impact on PET quantification. However, clinical impact on patient management remains to be determined.

Keywords: Fluorodesoxyglucose, positron emission tomography /computed tomography, respiratory gating, feasibility, Quantitative impact for lung or liver lesions, Systematic acquisition without increasing acquisition time

Received: 22 Nov 2017; Accepted: 31 Jan 2018.

Edited by:

Samer Ezziddin, Saarland University, Germany

Reviewed by:

John O. Prior, University of Lausanne, Switzerland
Andrea Schaefer, Universitätsklinikum des Saarlandes, Germany  

Copyright: © 2018 Robin, Bourhis, Bernard, ABGRAL, Querellou, Le Duc-Pennec, Le Roux and SALAUN. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Philippe Robin, Centre Hospitalier Regional Universitaire (CHU) de Brest, Service de Médecine Nucléaire,, 2 avenue Foch, Brest, 29609, France, philippe.robin@chu-brest.fr