The Non-Hemostatic Aspects of Transfused Platelets
- 1Établissement Français du Sang, France
- 2Groupe Sur L'immunité Des Muqueuses Et Agents Pathogènes (GIMAP), France
- 3Médecine Intensive Réanimation, Centre Hospitalier Regional Universitaire (CHU) de Brest, France
- 4Institute for Immunology and Transfusion Medicine, University of Greifswald, Germany
- 5Institut National de la Transfusion Sanguine, France
Platelets transfusion is a safe process, but during or after the process the recipient may experience an adverse reaction and occasionally a serious adverse reaction (SAR). In this review, we focus on the inflammatory potential of platelet components and their involvement in SARs. Recent evidence has highlighted a central role for platelets in the host inflammatory and immune responses. Blood platelets are involved in inflammation and various other aspects of innate immunity through the release of a plethora of immunomodulatory cytokines, chemokines and associated molecules, collectively termed biological response modifiers (BRMs) that behave like ligands for endothelial and leukocyte receptors and for platelets themselves. The involvement of platelet components in SARs – particularly on a critically ill patient’s context - could be related, at least in part, to the inflammatory functions of platelets, acquired during storage lesions. Moreover, we focus on causal link between platelet activation and immune-mediated disorders (Transfusion-Associated Immunomodulation, Platelets, Polyanions and Bacterial Defense and Alloimmunization). This is linked to the platelets’ propensity to be activated even in the absence of deliberate stimuli and to the occurrence of time-dependent storage lesions.
Keywords: platelets, transfusion, CD40L, serious adverse reaction, Inflammation
Received: 01 Dec 2017;
Accepted: 06 Feb 2018.
Edited by:Michel Prudent, Transfusion Interrégionale CRS SA, Switzerland
Reviewed by:Krystalyn E. Hudson, Bloodworks Northwest Research Institute, United States
Wei Li, Marshall University, United States
Copyright: © 2018 Sut, Tariket, Aubron, Aloui, Cognasse, Berthelot, LARADI, Greinacher, Garraud and Cognasse. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dr. Fabrice Cognasse, COGNASSE., Établissement Français du Sang, Paris, France, email@example.com