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Study Protocol ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Med. | doi: 10.3389/fmed.2019.00236

A randomized clinical trial comparing three different exercise strategies for optimizing aerobic capacity and skeletal muscle performance in older adults: Protocol for The DART Study

  • 1Ohio Musculoskeletal and Neurological Institute (OMNI), Ohio University, United States
  • 2Laboratory of Integrative Muscle Physiology, Department of Physical Therapy, Ohio University, United States
  • 3School of Applied Health Sciences and Wellness, Division of Athletic Training, Ohio University, United States
  • 4School of Applied Health Sciences and Wellness, Division of Exercise Physiology, Ohio University, United States
  • 5Diabetes Institute, Ohio University, United States

Background: Age-related declines in physical function lead to decreased independence and higher healthcare costs. Individuals who meet the endurance and resistance exercise recommendations can improve their physical function and overall fitness, even into their ninth decade. However, most older adults do not exercise regularly, and the majority of those who do only perform one type of exercise, and in doing so are not getting the benefits of endurance or resistance exercise. Herein we present the study protocol for a randomized clinical trial that will investigate the potential for high-intensity interval training to improve maximal oxygen consumption, muscular power, and muscle volume (primary outcomes), as well as body composition, 6-minute walk distance, and muscular strength and endurance (secondary outcomes).
Methods and Analysis: This is a single-site, single-blinded, randomized clinical trial. A minimum of 21 and maximum of 30 subjects aged 60-75 that are generally healthy but insufficiently active will be randomized. After completion of baseline assessments, participants will be randomized in a 1:1:1 ratio to participate in one of three 12-week exercise programs: stationary bicycle high-intensity interval training, stationary bicycle moderate-intensity continuous training, or resistance training. Repeat assessments will be taken immediately post intervention.
Discussion: This study will examine the potential for stationary bicycle high-intensity interval training to result in both cardiorespiratory and muscular adaptations in older adults. The results will provide important insights into the effectiveness of interval training, and potentially support a shift from volume-driven to intensity-driven exercise strategies for older adults.

Keywords: Aging, Exercise, interval, Resistance, Aerobic, power, VO2, Muscle

Received: 08 Jul 2019; Accepted: 07 Oct 2019.

Copyright: © 2019 Tavoian, Russ, Law, Simon, Chase, Guseman and Clark. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mr. Dallin Tavoian, Ohio University, Ohio Musculoskeletal and Neurological Institute (OMNI), Athens, 45701, West Virginia, United States,