Recent advances: Decoding Alzheimer’s disease with stem cells
- 1dapartment of neurology, Second Affiliated Hospital of Zhejiang University School of Medicine, China
Alzheimer’s disease (AD) is an irreversible neurodegenerative disorder that destroys cognitive functions. Recently, a number of high-profile clinical trials based on the amyloid cascade hypothesis have encountered disappointing results. The failure of these trials indicates the necessity for novel therapeutic strategies and disease models. In this review, we will describe how recent advances in stem cell technology have shed light on a novel treatment strategy and revolutionized the mechanistic investigation of AD pathogenesis. Current advances in promoting endogenous neurogenesis and transplanting exogenous stem cells from both bench research and clinical translation perspectives will be thoroughly summarized. In addition, reprogramming technology-based disease modeling, which has shown improved efficacy in recapitulating pathological features in human patients, will be discussed.
Keywords: Alzheimer’s disease, Neurogenesis, Stem Cell Transplantation, induced pluripotent stem cell, disease modeling
Received: 14 Oct 2017;
Accepted: 07 Mar 2018.
Edited by:Catarina Oliveira, University of Coimbra, Portugal
Reviewed by:Charles Harrington, University of Aberdeen, United Kingdom
Mariagrazia Grilli, Università degli Studi del Piemonte Orientale, Italy
Copyright: © 2018 Fang, Gao, Zhang and Pu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: PhD. Jiali Pu, Second Affiliated Hospital of Zhejiang University School of Medicine, dapartment of neurology, Hangzhou, China, email@example.com