Frontiers in Aging Neuroscience

Original Research

Published on 13 May 2026

Functional autonomy, comorbidities and cognitive decline: a mediation analysis in neurocognitive disorders

in Alzheimer's Disease and Related Dementias

Giuseppe Valente
Claudia Bauco
Carmela Bucca
Francesca Corte
Alessandra Petrillo
Daniele Tonietti
Nadia Di Sturco
Pierluigi Diotaiuti

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1776156

285 views

Original Research

Published on 13 May 2026

Stereoselective effects of nicotine enantiomers on the gut-brain axis and neuroinflammation in a mouse model of Parkinson’s disease

in Parkinson’s Disease and Aging-related Movement Disorders

Ruixia Liu
Yunu Ma
Yingyan Li
Xia Gao
Shu Wang
Lutao Xu
Guanglin Liu
Huan Chen
Min Ji
Hongwei Hou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1823372

245 views

Original Research

Published on 13 May 2026

Nuclear accumulation of PANK4 in hippocampal astrocytes aggravates cuproptosis in association with mild cognitive impairment in aged mice

in Neurocognitive Aging and Behavior

Bo Wang
Jing Zhang
Chang-Hong Li
Xiao Huang
Ruo-Bing Gao
Yan Peng
Qing Xie
Ya-Lei Ning
Yan Zhao
Nan Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1816702

241 views

Original Research

Published on 13 May 2026

From muscle to brain: the mediating effect of vitamin D in the relationship between muscle loss and cognitive function in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Xiaoting Ma
Linlin Yao
Fangbo Li
Chong Cui
Erlei Wang
Caishan Wang
Ping Zhao
Xiaofen Weng
Chunfeng Liu
Shanwen Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1630798

270 views

Systematic Review

Published on 13 May 2026

Efficacy of repeated external cueing training on freezing of gait and gait performance in Parkinson’s disease: a systematic review and meta-analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Qingling Sun
Wangfang Yu
Huafu Ni

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1808824

283 views

Original Research

Accepted on 12 May 2026

Unravelling the Role of HIF-1 in Peripheral Blood Mononuclear Cells from Older Patients with Alzheimer's Disease

in Cellular and Molecular Mechanisms of Brain-aging

Beatrice Arosio
Evelyn Ferri
Paolo Dionigi Rossi
Jacopo Aiello
Simone Caponetto
Fabiola Olivieri
Chiara Fenoglio
Daniela Galimberti
Tiziano Lucchi
Nicola Montano

Frontiers in Aging Neuroscience

Original Research

Accepted on 12 May 2026

SVIP in Plasma: A Candidate Blood-based Biomarker for Early Detection of Amnestic Mild Cognitive Impairment

in Alzheimer's Disease and Related Dementias

Gaigai Lu
Hui Shan
Yuxin Yin
Lele Chen
Keyan Yu
Zhuonan Wei
Hui Chen
Lin Hu
Yulong Qi
Tong Wu

Frontiers in Aging Neuroscience

Mini Review

Accepted on 12 May 2026

Multiple System Atrophy: Integrating Clinical Phenotypes and Multimodal Biomarkers for Early Diagnosis

in Parkinson’s Disease and Aging-related Movement Disorders

Ida Wilkens
Franziska Hopfner

Frontiers in Aging Neuroscience

Original Research

Published on 12 May 2026

Dopamine 2 receptor ablation from cholinergic neurons attenuates L-DOPA induced dyskinesias

in Parkinson’s Disease and Aging-related Movement Disorders

Santiago Uribe-Cano
Lauren Malave
Andreas H. Kottmann

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1779861

451 views

Review

Accepted on 11 May 2026

Treg–Microglia Crosstalk in Alzheimer's Disease: Stage-Dependent Dynamics, Molecular Mechanisms, and Translational Challenge

in Alzheimer's Disease and Related Dementias

Hua Fu
Jing Yang
Miao Zhang

Frontiers in Aging Neuroscience

Perspective

Accepted on 11 May 2026

Behind the Scenes of a 7T MRI Clinical Study in Alzheimer's Disease: Challenges and Recommendations for Future Research

in Alzheimer's Disease and Related Dementias

Maria Dobrushina
Friedrich Krohn
Sayyeda Chandni
Linda Dietrich
Wenzel Glanz
Michaela Butryn
Dorothea Hämmerer
Lucía Penalba-Sánchez

Frontiers in Aging Neuroscience

Original Research

Published on 11 May 2026

Decreases in the sustained firing capacity of layer 2/3 pyramidal neurons in the anterior cingulate cortex of aged rats

in Cellular and Molecular Mechanisms of Brain-aging

Taketoshi Sugimura
Yasuhiko Saito

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1824113

387 views

Correction

Accepted on 09 May 2026

Correction: Age-group differences between young and middle-aged adults in spatiotemporal EEG dynamics revealed by instantaneous frequency microstate analysis

in Neurocognitive Aging and Behavior

Sou Nobukawa
Takashi Ikeda
Mitsuru Kikuchi
Tetsuya Takahashi

Frontiers in Aging Neuroscience

318 views

Retraction

Accepted on 08 May 2026

Retraction: Repurposing food molecules as a potential BACE1 inhibitor for Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Frontiers Editorial Office

Frontiers in Aging Neuroscience

158 views

Review

Accepted on 08 May 2026

Gerobiotics and Neuroprotection: Effects on the Gut-Brain Axis in Age-Related Neurodegenerative Diseases

in Cellular and Molecular Mechanisms of Brain-aging

Betul KOCAADAM-BOZKURT
Serkan Aslan
Osman BOZKURT
Mahmut Bodur
Duygu Ağagündüz
Ferenc Budan

Frontiers in Aging Neuroscience

138 views

Original Research

Accepted on 08 May 2026

Near-gaze fixation promotes use of spin turns during walking: age-independent visuomotor effects with maladaptive behavioral consequences in older adults

in Neurocognitive Aging and Behavior

Juntaro Sakazaki
Daisuke muroi
Takahiro Higuchi

Frontiers in Aging Neuroscience

121 views

Original Research

Published on 08 May 2026

Route efficiency in spatial navigation as an early indicator of cognitive decline in amnestic mild cognitive impairment

in Alzheimer's Disease and Related Dementias

Nicole Rogers
Carol Dazil SanMartín
Jamileth More
César Romero
Daniela Paz Ponce
José Luis Valdés
María Isabel Behrens

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1797674

416 views

Review

Published on 08 May 2026

Transcranial magnetic stimulation from healthy brain aging to Alzheimer’s disease: a review on mechanisms, therapeutic potential, and future clinical directions

in Neurocognitive Aging and Behavior

Faddi Saleh Velez
Maria Cedeno-Bruzual
Melba Zuniga-Gutierrez
Daniela Mercado Pena
Cade L. Ballard
Jeng S. Kong
Ana Clara Da C. Pinaffi-Langley
Cameron D. Owens
Zsuzsanna TucsekCardon
Zsofia Szarvas

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1778992

538 views

Original Research

Published on 08 May 2026

Aging modulates amyloid clearance kinetics during anti-amyloid therapy: evidence from real-world serial amyloid PET

in Alzheimer's Disease and Related Dementias

Tomomichi Iizuka
Toshiaki Watanabe
Masashi Kameyama

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1801267

540 views

Original Research

Published on 08 May 2026

Entorhinal cortex atrophy mediates the association of plasma p-tau181, GFAP, and NfL with cognitive impairment in Parkinson’s disease

in Parkinson’s Disease and Aging-related Movement Disorders

Qiangqiang Wan
Xinyu Dai
Zhongwen Zhang
Ping Shan
Gui Mei
Luqi Huang
Lan Wang
Hongfen Peng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1791756

330 views

Review

Accepted on 07 May 2026

Application of Neurodegenerative Disease Treatment Strategies in Tinnitus: Mechanisms, Translation, and Prospects

in Neurocognitive Aging and Behavior

Peng Liu
Jingjing Liu

Frontiers in Aging Neuroscience

131 views

Systematic Review

Published on 07 May 2026

Intranasal administration of stem cells and their derivatives for neurological and respiratory disorders: a systematic review of human clinical trials

in Alzheimer's Disease and Related Dementias

Umm E. Habiba
Roshini Sathyanarayanan
Sabiha Shamim
Aishwarya Manian
Ammar Haider
Iqra Sarwar
David Lawrence Greene

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1834543

618 views

Brief Research Report

Published on 07 May 2026

Investigating hepatitis E virus seroprevalence in patients with Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Tiberiu Daniel Capraru
Tim Christopher Bauer
Paula Jordan
Niklas M. Weidner
Melisa Oensal
Lutz Froelich
Claudia Beisel
Lucrezia Hausner
Viet Loan Dao Thi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1831973

419 views

Hypothesis and Theory

Published on 07 May 2026

Food-chain spirochetes: a unified hypothesis for Parkinson’s disease and dementia risk

in Parkinson’s Disease and Aging-related Movement Disorders

Linda M. Sweeney

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1798699

593 views

8,005 articles

articles

Functional autonomy, comorbidities and cognitive decline: a mediation analysis in neurocognitive disorders

Stereoselective effects of nicotine enantiomers on the gut-brain axis and neuroinflammation in a mouse model of Parkinson’s disease

Nuclear accumulation of PANK4 in hippocampal astrocytes aggravates cuproptosis in association with mild cognitive impairment in aged mice

From muscle to brain: the mediating effect of vitamin D in the relationship between muscle loss and cognitive function in Alzheimer’s disease

Efficacy of repeated external cueing training on freezing of gait and gait performance in Parkinson’s disease: a systematic review and meta-analysis

Unravelling the Role of HIF-1 in Peripheral Blood Mononuclear Cells from Older Patients with Alzheimer's Disease

SVIP in Plasma: A Candidate Blood-based Biomarker for Early Detection of Amnestic Mild Cognitive Impairment

Multiple System Atrophy: Integrating Clinical Phenotypes and Multimodal Biomarkers for Early Diagnosis

Dopamine 2 receptor ablation from cholinergic neurons attenuates L-DOPA induced dyskinesias

Treg–Microglia Crosstalk in Alzheimer's Disease: Stage-Dependent Dynamics, Molecular Mechanisms, and Translational Challenge

Behind the Scenes of a 7T MRI Clinical Study in Alzheimer's Disease: Challenges and Recommendations for Future Research

Decreases in the sustained firing capacity of layer 2/3 pyramidal neurons in the anterior cingulate cortex of aged rats

Correction: Age-group differences between young and middle-aged adults in spatiotemporal EEG dynamics revealed by instantaneous frequency microstate analysis

Retraction: Repurposing food molecules as a potential BACE1 inhibitor for Alzheimer’s disease

Gerobiotics and Neuroprotection: Effects on the Gut-Brain Axis in Age-Related Neurodegenerative Diseases

Near-gaze fixation promotes use of spin turns during walking: age-independent visuomotor effects with maladaptive behavioral consequences in older adults

Route efficiency in spatial navigation as an early indicator of cognitive decline in amnestic mild cognitive impairment

Transcranial magnetic stimulation from healthy brain aging to Alzheimer’s disease: a review on mechanisms, therapeutic potential, and future clinical directions

Aging modulates amyloid clearance kinetics during anti-amyloid therapy: evidence from real-world serial amyloid PET

Entorhinal cortex atrophy mediates the association of plasma p-tau181, GFAP, and NfL with cognitive impairment in Parkinson’s disease

Application of Neurodegenerative Disease Treatment Strategies in Tinnitus: Mechanisms, Translation, and Prospects

Intranasal administration of stem cells and their derivatives for neurological and respiratory disorders: a systematic review of human clinical trials

Investigating hepatitis E virus seroprevalence in patients with Alzheimer’s disease

Food-chain spirochetes: a unified hypothesis for Parkinson’s disease and dementia risk