Frontiers in Aging Neuroscience

Original Research

Accepted on 20 Feb 2026

Distinguishing Early from Late Mild Cognitive Impairment: A Multi-level Analysis of Regional Morphometry and KLS-Derived Network Topology

in Alzheimer's Disease and Related Dementias

Peng Yan
Xinyu Du
Siyu Yang

Frontiers in Aging Neuroscience

Original Research

Accepted on 20 Feb 2026

Different stages of Alzheimer's disease with periodontitis: clinical features and potential mechanisms involving gingipains, neuropathological biomarkers and neurological damage

in Alzheimer's Disease and Related Dementias

Jing-hui Li
Teng-hong Lian
Peng Guo
Jing Li
Jing Qi
Ming-yue He
Dong-mei Luo
Ya-nan Zhang
Gai-fen Liu
Yue Huang

Frontiers in Aging Neuroscience

Review

Accepted on 20 Feb 2026

Targeting the astrocytic metabolic cascade inAlzheimer's disease: mechanisms, challenges and opportunities

in Alzheimer's Disease and Related Dementias

Huawen Cao
Junyi Liang
Xiaohong Dong
Zhiqi Xia
Xiaoting Luo
Bin Liu

Frontiers in Aging Neuroscience

Original Research

Published on 20 Feb 2026

Toward an understanding of real-world mobility in Parkinson’s: insights from enhanced contextualisation using GPS-derived location and data-driven modeling of walking speed

in Parkinson’s Disease and Aging-related Movement Disorders

Cameron Kirk
Rana Zia Ur Rehman
Brook Galna
Saverio Ranciati
Emma Packer
Neil Ireson
Vitaveska Lanfranchi
Claudia Mazzà
Lisa Alcock
Lynn Rochester

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1746429

272 views

Original Research

Published on 20 Feb 2026

Association between frailty and cognitive impairment in elderly patients with acute cerebral infarction

in Neurocognitive Aging and Behavior

Xiangjun Tao
Ying Wang
Shu Ding

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1709355

112 views

Study Protocol

Accepted on 19 Feb 2026

A novel virtual reality-integrated multi-modal intervention for community-dwelling older adults with mild cognitive impairment: Protocol for a randomized controlled trial

in Alzheimer's Disease and Related Dementias

Yuanbao Sun
Zhuorong Zi
Songli Wang
Minghui Weng
Jin Peng
Linwan Liu
Jian Zhou
Nianjie Wang
Bo Liu
Kezhi Liu

Frontiers in Aging Neuroscience

Original Research

Published on 19 Feb 2026

Age-related decline in temporal sound processing: insights from envelope steepness map in the mouse auditory cortex

in Cellular and Molecular Mechanisms of Brain-aging

Tianrui Guo
Kuniyuki Takahashi
Shinsuke Ohshima
Tatsuya Yamagishi
Shuji Izumi
Chihiro Yagi
Ryota Kai
Akira Kimura
Hiroaki Tsukano
Arata Horii

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1730629

249 views

Systematic Review

Published on 19 Feb 2026

The genetic architecture of Parkinson's disease in Mexico: a systematic review

in Parkinson’s Disease and Aging-related Movement Disorders

Oscar Arias-Carrión
Elizabeth Romero-Gutiérrez
Francisco X. Castellanos-Juárez
Ada A. Sandoval-Carrillo
José M. Salas-Pacheco

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1709246

288 views

Review

Accepted on 18 Feb 2026

Emerging Pathological Mechanisms of Alzheimer's Disease Pathogenesis: From Neuroimmune Interactions to Intercellular Communication

in Alzheimer's Disease and Related Dementias

Rutong Wang
Yingqi Feng
Ziyu Zhou
Jiajun Jiang
Runze Zhang
Wenhui Zou
Haotian Yang
Wenbo Lv
Shen Yang

Frontiers in Aging Neuroscience

Original Research

Accepted on 18 Feb 2026

Systemic Proteomic and Organ Aging Signatures Associated with plasma Aβ Oligomerization in a Korean cohort: A Cross-Sectional Study

in Alzheimer's Disease and Related Dementias

Hyunjung Oh
Hongju Kim
Hojin Kang
Dohyeon Kwon
Leon French
Young Ho Park
YOUNG CHUL YOUN
SangYun Kim
Sungmin Kang

Frontiers in Aging Neuroscience

Original Research

Accepted on 18 Feb 2026

Age-related changes in static and dynamic postural balance performance

in Neurocognitive Aging and Behavior

Alex Rizzato
Matteo Bozzato
Antonio Paoli
Sara Faggian
Giuseppe Marcolin

Frontiers in Aging Neuroscience

Original Research

Accepted on 18 Feb 2026

Exploring the neuroprotective mechanism of Tongqiao Huashuan granules in vascular dementia based on PLCγ1/IP3R signaling pathway

in Alzheimer's Disease and Related Dementias

Xianhui Huang
Jiajia Liu
Yanna Ren
Dingding Liu
Jing Cai
Liping Cao
Lei Tong
Yuanhua Wu

Frontiers in Aging Neuroscience

Review

Accepted on 18 Feb 2026

The Brain-Gut-Muscle Axis: A Mechanism for Exercise-Mediated Protection in Brain Aging

in Neurocognitive Aging and Behavior

Wenyu Sun
WanHong Wang
Huifen Liu
Yu Zhang
Linlin Li
Bin Liu

Frontiers in Aging Neuroscience

Original Research

Published on 18 Feb 2026

Systems-level molecular and immunological evidence identifies Th17/Treg modulation as a key mechanism of CRSJ’s neuroprotection in Parkinson’s disease

in Parkinson’s Disease and Aging-related Movement Disorders

Xun Li
XiYu Li
ShiYa Chen
Lin Wang
JinYan Xia
MeiLing Zheng
ChuTian Zhang
XiaoQian Chen
Jing Cai

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1764634

171 views

Original Research

Published on 18 Feb 2026

Insulin resistance (TyG index) and body mass index as metabolic biomarker combined with ApoE genotype to diagnose Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Renyu Chen
Shiyu Fan
Cihan Di
Hao Wu
Zhihong Shi
Feng Liu
Zhaoyang Lv
Shuai Liu
Yong Ji

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1731547

398 views

Original Research

Accepted on 17 Feb 2026

Privacy and Personalisation: Predicting Parkinson's Disease Severity from Real-World Gait with Federated Learning

in Parkinson’s Disease and Aging-related Movement Disorders

Chloe Hanna Louise Hinchliffe
Hugo Hiden
Lisa Alcock
Rachael A Lawson
Alison J Yarnall
Lynn Rochester
Silvia Del Din
Paul Watson

Frontiers in Aging Neuroscience

Brief Research Report

Accepted on 17 Feb 2026

Effect of inspired oxygen fraction during anesthesia on inflammation and antioxidant enzyme activity in the mouse cortex and hippocampus

in Neuroinflammation and Neuropathy

Jin-Young Hwang
Jee-Eun Chang
Elliot H Lee
Soo-Jin Oh

Frontiers in Aging Neuroscience

Original Research

Published on 17 Feb 2026

Development and validation of a clinical prediction model for first fall in early Parkinson’s disease: a study of two fall-naive cohorts

in Parkinson’s Disease and Aging-related Movement Disorders

Yu Wang
Jianing Mei
Yunzhe Tang
Hongping Zhao
Zijun Wei
Qingliang Tao
Xueyi Han
Jiyuan Hu
Yunyun Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1735524

218 views

Brief Research Report

Published on 16 Feb 2026

Putative sympathetic-predominant subtype in body-first Parkinson’s disease is associated with accelerated cognitive decline

in Parkinson’s Disease and Aging-related Movement Disorders

Xining Liu
Zhiheng Xu
Xiuyuan Li
Chenqin Xu
Shiyu Li
Tianyu Hu
Chen Chen
Xiaoniu Liang
Yilin Tang
Jian Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1747748

225 views

Original Research

Published on 16 Feb 2026

Association between end-tidal sevoflurane concentration and postoperative cognitive dysfunction and pain sensitivity in elderly patients under general anesthesia

in Neurocognitive Aging and Behavior

Yunyun Zhou
Han Zheng
Zhengyu Li
Jiaxuan Wang
Xue Zhang
Lifen Zheng
Hong Luo
Heng Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1761052

197 views

Original Research

Published on 16 Feb 2026

Cooling the burn: EMLA alone vs. paravertebral block plus EMLA for improving tolerability of 8% capsaicin patch application in thoracic postherpetic neuralgia—a retrospective cohort study

in Neuroinflammation and Neuropathy

Hassan A. Moria

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1762229

198 views

Brief Research Report

Published on 16 Feb 2026

Alterations in energy production in a Drosophila model for the X-linked dystonia-parkinsonism-related Taf1 deficiency

in Parkinson’s Disease and Aging-related Movement Disorders

Frida Mandik
Shela Marie Algodon
Philip Seibler
Christine Klein
Melissa Vos

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1684267

234 views

Original Research

Published on 16 Feb 2026

Behavioral deficits and exacerbated neural and hemodynamic odor responses during lifespan of a mouse model of late onset Alzheimer’s disease expressing humanized APOEε4 and Trem2*R47H

in Alzheimer's Disease and Related Dementias

Misha Izydorczak
Maggie Oumov
Mansiben V. Udhwani
Faysal Fostok
Guillermo Coronas-Samano
Basavaraju G. Sanganahalli
Peter Herman
Fahmeed Hyder
Justus V. Verhagen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1622135

Original Research

Accepted on 13 Feb 2026

Association of Perivascular Diffusion with White-matter Microstructural Integrity, Free Water, Aβ Burden, and Cognition: Diffusion Tensor vs. Kurtosis Tensor

in Alzheimer's Disease and Related Dementias

Zhiming Zeng
Xin Jia
Shushu Han
Cuidie Zeng
Jing Bi
Lingchen Liu
Yueming Wu
Tengao Gao
Lei Liang
Fangxiao Cheng

Frontiers in Aging Neuroscience

7,819 articles

articles

Distinguishing Early from Late Mild Cognitive Impairment: A Multi-level Analysis of Regional Morphometry and KLS-Derived Network Topology

Different stages of Alzheimer's disease with periodontitis: clinical features and potential mechanisms involving gingipains, neuropathological biomarkers and neurological damage

Targeting the astrocytic metabolic cascade inAlzheimer's disease: mechanisms, challenges and opportunities

Toward an understanding of real-world mobility in Parkinson’s: insights from enhanced contextualisation using GPS-derived location and data-driven modeling of walking speed

Association between frailty and cognitive impairment in elderly patients with acute cerebral infarction

A novel virtual reality-integrated multi-modal intervention for community-dwelling older adults with mild cognitive impairment: Protocol for a randomized controlled trial

Age-related decline in temporal sound processing: insights from envelope steepness map in the mouse auditory cortex

The genetic architecture of Parkinson's disease in Mexico: a systematic review

Emerging Pathological Mechanisms of Alzheimer's Disease Pathogenesis: From Neuroimmune Interactions to Intercellular Communication

Systemic Proteomic and Organ Aging Signatures Associated with plasma Aβ Oligomerization in a Korean cohort: A Cross-Sectional Study

Age-related changes in static and dynamic postural balance performance

Exploring the neuroprotective mechanism of Tongqiao Huashuan granules in vascular dementia based on PLCγ1/IP3R signaling pathway

The Brain-Gut-Muscle Axis: A Mechanism for Exercise-Mediated Protection in Brain Aging

Systems-level molecular and immunological evidence identifies Th17/Treg modulation as a key mechanism of CRSJ’s neuroprotection in Parkinson’s disease

Insulin resistance (TyG index) and body mass index as metabolic biomarker combined with ApoE genotype to diagnose Alzheimer’s disease

Privacy and Personalisation: Predicting Parkinson's Disease Severity from Real-World Gait with Federated Learning

Effect of inspired oxygen fraction during anesthesia on inflammation and antioxidant enzyme activity in the mouse cortex and hippocampus

Development and validation of a clinical prediction model for first fall in early Parkinson’s disease: a study of two fall-naive cohorts

Putative sympathetic-predominant subtype in body-first Parkinson’s disease is associated with accelerated cognitive decline

Association between end-tidal sevoflurane concentration and postoperative cognitive dysfunction and pain sensitivity in elderly patients under general anesthesia

Cooling the burn: EMLA alone vs. paravertebral block plus EMLA for improving tolerability of 8% capsaicin patch application in thoracic postherpetic neuralgia—a retrospective cohort study

Alterations in energy production in a Drosophila model for the X-linked dystonia-parkinsonism-related Taf1 deficiency

Behavioral deficits and exacerbated neural and hemodynamic odor responses during lifespan of a mouse model of late onset Alzheimer’s disease expressing humanized APOEε4 and Trem2*R47H

Association of Perivascular Diffusion with White-matter Microstructural Integrity, Free Water, Aβ Burden, and Cognition: Diffusion Tensor vs. Kurtosis Tensor