Frontiers in Aging Neuroscience

Original Research

Published on 17 Aug 2026

Acute total sleep deprivation transiently increases plasma total tau but not plasma P-tau181 in healthy adults

in Alzheimer's Disease and Related Dementias

Beiyu Zhao
Meng Wei
Suhang Shang
Ling Gao
Shan Wei
Liangjun Dang
Jie Liu
Chen Chen
Yanbo Li
Jin Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1904137

191 views

Review

Published on 17 Aug 2026

Role of STX1A in Parkinson’s disease: evidence, mechanistic hypotheses, and translational perspectives

in Parkinson’s Disease and Aging-related Movement Disorders

Rui Xu
Rui Li
Hongmei Li
Qingyun Li
Yanping Li
Gang Wu
Xiaolin Dong

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1905708

211 views

Review

Published on 17 Aug 2026

Direct toll-like receptor 4 inhibition in Alzheimer’s disease models: a focused scoping review of inflammatory, amyloid-handling, and functional outcomes

in Alzheimer's Disease and Related Dementias

Xiaolu Ren
Xinyu Jin
Ling Li
Fang Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1889254

260 views

Review

Published on 17 Aug 2026

P2X7 receptor-dependent microglia-astrocyte coupling in Alzheimer's disease: from eATP sensing to synaptic and proteostatic failure

in Cellular and Molecular Mechanisms of Brain-aging

Yiwen Li
Shiming Liu
Jiao Lan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1915244

177 views

Review

Published on 17 Aug 2026

From pathology to network failure: a Question–Model–Outcome framework for interpreting animal models of AD-related and dementia-relevant mechanisms

in Alzheimer's Disease and Related Dementias

Umut Şimşekçi
Yıldırım Cesaretli

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1882211

272 views

Original Research

Accepted on 14 Aug 2026

Gait Characteristics in Older Adults using the ProtoKinetics Zeno™ Walkway: The Atherosclerosis Risk in Communities (ARIC) Study

in Neurocognitive Aging and Behavior

Katherine J Hunzinger
Laura Skow
Andrea Lauren Christman Schneider
Michael Griswold
Xiaoqian Zhu
Farwa Ali
Pamela L. Lutsey
Jennifer A. Schrack
Luigi Ferrucci
Eleanor Simonsick

Frontiers in Aging Neuroscience

128 views

Review

Accepted on 14 Aug 2026

Data-Driven Subtyping of Parkinson's Disease Using MRI: Current Insights, Challenges, and Future Directions

in Parkinson’s Disease and Aging-related Movement Disorders

Anupa A Vijayakumari
Ken Sakaie
Hubert H Fernandez
Benjamin L. Walter

Frontiers in Aging Neuroscience

142 views

Original Research

Accepted on 14 Aug 2026

Brain Metabolic and Network Profiles Characterized by Comorbid Depressive Symptoms and Sleep Disturbances in Parkinson’s Disease: An 18F-FDG PET Study

in Parkinson’s Disease and Aging-related Movement Disorders

Kaidi Li
Caihua Bao
Yinxia Wang
Chunyu Zhang
Xin'ai Wu
Yaping Du
Yikai Shu
Yadong Fan
Pusheng Quan
Zhijun Li

Frontiers in Aging Neuroscience

137 views

Original Research

Accepted on 14 Aug 2026

Structural and Functional Alterations of Posterior Cingulate Cortex Subregions in Successful Cognitive Aging

in Neurocognitive Aging and Behavior

Jie Wang
Yunfei Li
Tianyuyi Feng
Ruixia Xu
Jiaqi Li
Yanling Zheng
Yang Hu
Xiaohu Zhao

Frontiers in Aging Neuroscience

130 views

Original Research

Published on 14 Aug 2026

Restoring anticipatory control through cognitive–motor dual-task training improves emotional and executive function in frail older adults

in Neurocognitive Aging and Behavior

Luca Boccacci
Martina Scalia
Riccardo Borzuola
Valentina Camomilla
Domenico Campagna
Andrea Casella
Imma Ceriello
Natalie Ferrulli
Margherita Filosa
Chiara Fossati

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1890281

401 views

Original Research

Published on 14 Aug 2026

A male rat model integrating hypertension, chronic cerebral hypoperfusion, and aging recapitulates multimodal cerebral small vessel disease phenotypes

in Neuroinflammation and Neuropathy

Zhiwei Feng
Shan Han
Yanyi Li
Zhenzhen Li
Yige Tu
Bin Wu
Shengjie Zhu
Qin Zheng
Wenjun Sun

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1906043

428 views

Study Protocol

Published on 14 Aug 2026

Multimodal characterization of cortical hyperexcitability as a driver of cognitive decline in neurocognitive disorders: study protocol for the LENDÜLET Neurocognitive Research Project

in Neurocognitive Aging and Behavior

András Attila Horváth

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1809381

307 views

Review

Published on 14 Aug 2026

Exercise alone or combined with functional foods in aging and age-related diseases: targeting DNA damage, repair pathways, and genome integrity

in Cellular and Molecular Mechanisms of Brain-aging

Ying Ma
Xuejun Li
He Chen
Rongchang Fan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1772217

391 views

Original Research

Published on 14 Aug 2026

Plasma α-synuclein and QSM-derived susceptibility in Parkinson’s disease: associations with clinical features

in Parkinson’s Disease and Aging-related Movement Disorders

Xingjun Li
Tianfei Luo
Jing Bai

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1740309

333 views

Systematic Review

Published on 14 Aug 2026

Effects of Tai Chi on functional performance and fall-related psychological outcomes in Parkinson’s disease: a systematic review and meta-analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Fusen Wang
Tongtong Hao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1860410

367 views

Review

Accepted on 13 Aug 2026

Dissecting Neuronal Circuit Function and Dysfunction in Alzheimer's disease mouse models: From Conventional Calcium Imaging Analysis to Machine Learning-Based Approaches

in Alzheimer's Disease and Related Dementias

Evgenii Gerasimov
Evgenii Fedorov
Ilya Bezprozvanny
Ekaterina Pchitskaya

Frontiers in Aging Neuroscience

205 views

Original Research

Accepted on 13 Aug 2026

Tau-induced increase in promoter-proximal RNA polymerase II pausing is linked to suppressed expression of long neuronal genes in a Drosophila tauopathy model

in Alzheimer's Disease and Related Dementias

Kendall Cottingham
Nima Goodarzi
David Fries
Geethma Lirushie
Hana Hall

Frontiers in Aging Neuroscience

193 views

Review

Accepted on 13 Aug 2026

The Association Between Hearing Loss in Adults and Cognitive Outcomes: An Umbrella Review and Meta-Analysis

in Alzheimer's Disease and Related Dementias

Jiao Liang
Penglong Yu
Qingzhu You
YANG Kun

Frontiers in Aging Neuroscience

222 views

Original Research

Published on 13 Aug 2026

Sex- and age-dependent associations between waist-to-hip ratio and cognitive impairment: a cross-sectional study of rural adults aged 40 years and older in northwestern China

in Alzheimer's Disease and Related Dementias

Simeng Cui
Yu Zhang
Qiqi Qiang
Ziyu Liu
Peijie Liu
Liangjun Dang
Jin Wang
Wenhui Lu
Kang Huo
Yu Jiang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1835459

461 views

Review

Published on 13 Aug 2026

Potential effects of β-hydroxy-β-methylbutyrate and exercise on brain aging and age-related disorders: implications for immunometabolic regulation and muscle–brain–immune crosstalk

in Cellular and Molecular Mechanisms of Brain-aging

Boyuan Shi
Zheng Han

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1878831

548 views

Original Research

Published on 13 Aug 2026

The molecular mechanisms of Guizhi Fuling Pills in ameliorating Alzheimer’s disease-like cognitive impairment: insights from transcriptomics, metabolomics, and gut microbiome

in Alzheimer's Disease and Related Dementias

Lan Ma
Jing Wang
Zhenghao Xu
Zuxiu Huang
Kelong Chen
Xiaoqiong Teng
Miao Chen
Shuyang Lin
Rong Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1839445

547 views

Systematic Review

Accepted on 12 Aug 2026

DTI-ALPS Index and Cognitive Impairment in Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis

in Neurocognitive Aging and Behavior

Xiaoxue Zeng
Mingxi Xu
Xia He
Xia-lian Huang
Yingying Yang
Fengle Mao
Xia He
Yan-qiu Wang

Frontiers in Aging Neuroscience

228 views

Original Research

Published on 12 Aug 2026

Cortical and subcortical morphological alterations in de novo GBA-related Parkinson’s disease

in Parkinson’s Disease and Aging-related Movement Disorders

Jingru Ren
Yi Xing
Hao Zhou
Xinyu Hong
Xiaofang Huang
Weiguo Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1885255

1,177 views

Original Research

Published on 12 Aug 2026

Stage-dependent clinical burden in hospitalized Parkinson’s disease with a positive bedside orthostatic hypotension screen: a retrospective cross-sectional analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Hengzhang Ma
Zhixiong Zheng
Caihua Chen
Mingyuan Xu
Qiaohui Zhu
Shenkun He

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1894279

297 views

8,278 articles

articles

Acute total sleep deprivation transiently increases plasma total tau but not plasma P-tau181 in healthy adults

Role of STX1A in Parkinson’s disease: evidence, mechanistic hypotheses, and translational perspectives

Direct toll-like receptor 4 inhibition in Alzheimer’s disease models: a focused scoping review of inflammatory, amyloid-handling, and functional outcomes

P2X7 receptor-dependent microglia-astrocyte coupling in Alzheimer's disease: from eATP sensing to synaptic and proteostatic failure

From pathology to network failure: a Question–Model–Outcome framework for interpreting animal models of AD-related and dementia-relevant mechanisms

Gait Characteristics in Older Adults using the ProtoKinetics Zeno™ Walkway: The Atherosclerosis Risk in Communities (ARIC) Study

Data-Driven Subtyping of Parkinson's Disease Using MRI: Current Insights, Challenges, and Future Directions

Brain Metabolic and Network Profiles Characterized by Comorbid Depressive Symptoms and Sleep Disturbances in Parkinson’s Disease: An 18F-FDG PET Study

Structural and Functional Alterations of Posterior Cingulate Cortex Subregions in Successful Cognitive Aging

Restoring anticipatory control through cognitive–motor dual-task training improves emotional and executive function in frail older adults

A male rat model integrating hypertension, chronic cerebral hypoperfusion, and aging recapitulates multimodal cerebral small vessel disease phenotypes

Multimodal characterization of cortical hyperexcitability as a driver of cognitive decline in neurocognitive disorders: study protocol for the LENDÜLET Neurocognitive Research Project

Exercise alone or combined with functional foods in aging and age-related diseases: targeting DNA damage, repair pathways, and genome integrity

Plasma α-synuclein and QSM-derived susceptibility in Parkinson’s disease: associations with clinical features

Effects of Tai Chi on functional performance and fall-related psychological outcomes in Parkinson’s disease: a systematic review and meta-analysis

Dissecting Neuronal Circuit Function and Dysfunction in Alzheimer's disease mouse models: From Conventional Calcium Imaging Analysis to Machine Learning-Based Approaches

Tau-induced increase in promoter-proximal RNA polymerase II pausing is linked to suppressed expression of long neuronal genes in a Drosophila tauopathy model

The Association Between Hearing Loss in Adults and Cognitive Outcomes: An Umbrella Review and Meta-Analysis

Sex- and age-dependent associations between waist-to-hip ratio and cognitive impairment: a cross-sectional study of rural adults aged 40 years and older in northwestern China

Potential effects of β-hydroxy-β-methylbutyrate and exercise on brain aging and age-related disorders: implications for immunometabolic regulation and muscle–brain–immune crosstalk

The molecular mechanisms of Guizhi Fuling Pills in ameliorating Alzheimer’s disease-like cognitive impairment: insights from transcriptomics, metabolomics, and gut microbiome

DTI-ALPS Index and Cognitive Impairment in Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis

Cortical and subcortical morphological alterations in de novo GBA-related Parkinson’s disease

Stage-dependent clinical burden in hospitalized Parkinson’s disease with a positive bedside orthostatic hypotension screen: a retrospective cross-sectional analysis