Frontiers in Aging Neuroscience

Brief Research Report

Published on 25 Jul 2025

Molecular targets of neuroplasticity in ischemic stroke: insights from GEO database, single-cell analysis and immune infiltration analysis

in Cellular and Molecular Mechanisms of Brain-aging

Haoyue Yang
Zekun Li
Lu Zhang
Haifeng Zhang
Yang Liu
Wei Chen
Feng Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1561282

907 views

Original Research

Published on 25 Jul 2025

Modeling and validation of wearable sensor-based gait parameters in Parkinson’s disease patients with cognitive impairment

in Parkinson’s Disease and Aging-related Movement Disorders

Guo Hong
Fengju Mao
Mingming Zhang
Fei Zhang
Xiangcheng Wang
Kang Ren
Zhonglue Chen
Xiaoguang Luo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1590224

222 views

Review

Accepted on 24 Jul 2025

Advancement in Modelling of Alzheimer's Disease: A Comprehensive Review of Preclinical Screening Platforms

in Alzheimer's Disease and Related Dementias

Souvik Adak
Shivam Singh
Ridhi Jain
Abhilasha Tiwari
Binny Singh
Sumit Kumar
Ayushi Dadhwal
Avishek Chakroborty
Ashish Kumar Sharma
Ravindra Pal Singh

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1646551

Original Research

Accepted on 24 Jul 2025

Bioinformatics and experimental validation identify biomarkers for diagnosing Alzheimer's disease

in Alzheimer's Disease and Related Dementias

Hui Liu
Chenye Li
Congchen Zhai
Mei Li
Lan Ma

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1566929

Original Research

Accepted on 24 Jul 2025

Relationship between the platelet-to-lymphocyte ratio and in-hospital mortality of ischemic stroke patients in the intensive care unit

in Neuroinflammation and Neuropathy

Guohua Liu
Hao Ding
Lin Chen
Lan Chen
Sufang Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1607332

Review

Accepted on 24 Jul 2025

Naringenin as a neurotherapeutic agent in Alzheimer's disease: Epigenetic signatures, gut microbiota alterations, and molecular neuroprotection

in Alzheimer's Disease and Related Dementias

Long Ke

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1647967

Original Research

Accepted on 24 Jul 2025

Accelerated Midlife Endocrine and Bioenergetic Brain Aging in APOE4 Females

in Alzheimer's Disease and Related Dementias

Tian Wang
Zisu Mao
Yuan Shang
Simona Merlini
Francesca Vitali
Jean-Paul Wiegand
Roberta Diaz Brinton

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1632877

Review

Published on 24 Jul 2025

NMDA receptors in neurodegenerative diseases: mechanisms and emerging therapeutic strategies

in Cellular and Molecular Mechanisms of Brain-aging

Keyi Zhang
Ming Wen
Xinyue Nan
Shuaizhu Zhao
Hao Li
Yanping Ai
Houze Zhu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1604378

507 views

Original Research

Published on 24 Jul 2025

Estimating progression of Alzheimer’s disease with extracellular vesicle-related multi-omics risk models

in Alzheimer's Disease and Related Dementias

Xiao Zhang
Sanoji Wijenayake
Shakhawat Hossain
Qian Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1617611

443 views

Mini Review

Published on 24 Jul 2025

GLP-1R as a potential link between diabetes and Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Shujun Li
Nanqu Huang
Mei Wang
Wendi Huang
Jingshan Shi
Yong Luo
Juan Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1601602

487 views

Correction

Accepted on 23 Jul 2025

Correction: Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis

in Cellular and Molecular Mechanisms of Brain-aging

Shumin Zhao
Ranran Chen
Yi An
Yali Zhang
Cheng Ma
Ying Gao
Yanchao Lu
Fei Yang
Xue Bai
Jingjing Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1670545

Original Research

Accepted on 23 Jul 2025

Accurate and Robust Prediction of Amyloid-B Brain Deposition from Plasma Biomarkers and Clinical Information Using Machine Learning

in Alzheimer's Disease and Related Dementias

Jiayuan Xu
Andrew J Doig
Sofia Michopoulou
Petroula Proitsi
Fumie Costen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1559459

148 views

Original Research

Published on 23 Jul 2025

Ambroxol confers neuroprotection against scopolamine-induced Alzheimer’s-like pathology by modulating oxidative stress, neuroinflammation, and cognitive deficits via Nrf-2/JNK/GSK-3β signaling pathways

in Cellular and Molecular Mechanisms of Brain-aging

Waqas Ahmad
Kyonghwan Choe
Riaz Ahmad
Tae Ju Park
Myeong Ok Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1607289

726 views

Review

Published on 23 Jul 2025

Tau and tauopathies across primate species: implications for modeling neurodegenerative disorders

in Alzheimer's Disease and Related Dementias

Julia C. Colwell
Marina E. Emborg

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1598245

450 views

Original Research

Published on 23 Jul 2025

Region-informed machine learning model for choroid plexus segmentation in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Liangdong Zhou
Tracy A. Butler
Xiuyuan H. Wang
Samantha A. Keil
Seyed Hani Hojjati
Tsung-Wei Hu
Mélissa Savard
Firoza Z. Lussier
Pedro Rosa-Neto
Lidia Glodzik

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1613320

583 views

Original Research

Published on 23 Jul 2025

Vulnerability of long-range inputome of basal forebrain in normal aging mice

in Cellular and Molecular Mechanisms of Brain-aging

Tingting Sun
Jiale Chen
Bimin Liu
Anan Li
Hui Gong
Xiangning Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1573906

574 views