Frontiers in Aging Neuroscience

Original Research

Published on 08 May 2026

Route efficiency in spatial navigation as an early indicator of cognitive decline in amnestic mild cognitive impairment

in Alzheimer's Disease and Related Dementias

Nicole Rogers
Carol Dazil SanMartín
Jamileth More
César Romero
Daniela Paz Ponce
José Luis Valdés
María Isabel Behrens

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1797674

273 views

Review

Published on 08 May 2026

Transcranial magnetic stimulation from healthy brain aging to Alzheimer’s disease: a review on mechanisms, therapeutic potential, and future clinical directions

in Neurocognitive Aging and Behavior

Faddi Saleh Velez
Maria Cedeno-Bruzual
Melba Zuniga-Gutierrez
Daniela Mercado Pena
Cade L. Ballard
Jeng S. Kong
Ana Clara Da C. Pinaffi-Langley
Cameron D. Owens
Zsuzsanna TucsekCardon
Zsofia Szarvas

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1778992

308 views

Original Research

Published on 08 May 2026

Aging modulates amyloid clearance kinetics during anti-amyloid therapy: evidence from real-world serial amyloid PET

in Alzheimer's Disease and Related Dementias

Tomomichi Iizuka
Toshiaki Watanabe
Masashi Kameyama

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1801267

277 views

Original Research

Published on 08 May 2026

Entorhinal cortex atrophy mediates the association of plasma p-tau181, GFAP, and NfL with cognitive impairment in Parkinson’s disease

in Parkinson’s Disease and Aging-related Movement Disorders

Qiangqiang Wan
Xinyu Dai
Zhongwen Zhang
Ping Shan
Gui Mei
Luqi Huang
Lan Wang
Hongfen Peng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1791756

213 views

Review

Accepted on 07 May 2026

Application of Neurodegenerative Disease Treatment Strategies in Tinnitus: Mechanisms, Translation, and Prospects

in Neurocognitive Aging and Behavior

Peng Liu
Jingjing Liu

Frontiers in Aging Neuroscience

Systematic Review

Published on 07 May 2026

Intranasal administration of stem cells and their derivatives for neurological and respiratory disorders: a systematic review of human clinical trials

in Alzheimer's Disease and Related Dementias

Umm E. Habiba
Roshini Sathyanarayanan
Sabiha Shamim
Aishwarya Manian
Ammar Haider
Iqra Sarwar
David Lawrence Greene

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1834543

447 views

Brief Research Report

Published on 07 May 2026

Investigating hepatitis E virus seroprevalence in patients with Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Tiberiu Daniel Capraru
Tim Christopher Bauer
Paula Jordan
Niklas M. Weidner
Melisa Oensal
Lutz Froelich
Claudia Beisel
Lucrezia Hausner
Viet Loan Dao Thi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1831973

316 views

Original Research

Published on 07 May 2026

Potential for distinguishing the parkinsonian subtype of multiple system atrophy from Parkinson’s disease: a three-dimensional gait analysis study

in Parkinson’s Disease and Aging-related Movement Disorders

Reyisha Taximaimaiti
Sheng Cai
Hongyan Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1797960

291 views

Hypothesis and Theory

Published on 07 May 2026

Food-chain spirochetes: a unified hypothesis for Parkinson’s disease and dementia risk

in Parkinson’s Disease and Aging-related Movement Disorders

Linda M. Sweeney

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1798699

460 views

Original Research

Accepted on 06 May 2026

Predicting time across age: Comparing performance and neural dynamics of younger and older adults in a temporal prediction task

in Neurocognitive Aging and Behavior

Marleen J. Schoenfeld
Rebecca Burke
Till R Schneider
Andreas K Engel

Frontiers in Aging Neuroscience

Review

Accepted on 05 May 2026

Cognitive Decline and Reduced Bone Mineral Density Under the Bone-Brain Axis: Mechanistic Insights and Imaging Evaluation Strategies

in Alzheimer's Disease and Related Dementias

Yunhai Mao
Zhe Sui
Mengchao Zhang
Yihang Ma

Frontiers in Aging Neuroscience

Original Research

Accepted on 05 May 2026

Searching for a needle in a haystack – Ambulatory research in Parkinson`s disease in Germany

in Parkinson’s Disease and Aging-related Movement Disorders

Ingmar Wellach
Christoph Redecker
Susann Eichler
Lisa Hillmer
Dirk Becker
Honorine Atanga
Kristina Schmidt
Isabel Doblinger

Frontiers in Aging Neuroscience

Original Research

Accepted on 05 May 2026

Distinct aging-related profiles of allocentric knowledge recall following navigation in an immersive, naturalistic, city-like environment

in Neurocognitive Aging and Behavior

Yasmine Bassil
Anisha Kanukolanu
Emma Funderburg
Emily Cui
Thackery Brown
Michael Borich

Frontiers in Aging Neuroscience

Original Research

Published on 05 May 2026

No associations between blood pressure and brain volumes in a convenience sample of Hispanic/Latino middle-aged and older adults

in Alzheimer's Disease and Related Dementias

Carolina L. Costa
Carlos E. E. Araujo-Menendez
Alyssa Lawrence
Alonzo Mendoza
Wassim Tarraf
Ariana M. Stickel

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1729134

438 views

Correction

Published on 05 May 2026

Correction: Elevated gonadotropins and risk of dementia in Chinese adults aged over 80: a cross-sectional study

in Alzheimer's Disease and Related Dementias

Yunxia Zhu
Youyi Tu
Chenxi Ren
Yingying Ke
Qihao Guo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1859014

240 views

Original Research

Accepted on 04 May 2026

Integrating Memory-Guided Saccades and EEG for MCI Screening: A Multimodal LASSO Modeling Approach

in Neurocognitive Aging and Behavior

Xinying Zhao
Fuda Yu
Hui Wang
Yanling Kang
Yiting Zhu
Zhongfeng Xiao
Donger Bai
Jiamin Li

Frontiers in Aging Neuroscience

Brief Research Report

Accepted on 04 May 2026

Lateralization of interictal epileptic discharges differently impacts cognitive performance and behavior in late-onset epilepsy of unknown aetiology

in Neurocognitive Aging and Behavior

Giusy Bergamo
Mariana Fernandes
Gianluca Albanesi
Matteo Antonucci
Ilaria Barbaro
Beatrice Bertini
Flavia Cirillo
Valentina Corsi
Silvia Maio
Greta Testone

Frontiers in Aging Neuroscience

Editorial

Accepted on 04 May 2026

Editorial: Mitochondrial Dysfunction in Cellular and Molecular Mechanisms of Brain Aging

in Cellular and Molecular Mechanisms of Brain-aging

Pei Shang
Ying Li
Aswathy Peethambaran Mallika
Meghraj Singh Baghel
Bhupendra V Shravage

Frontiers in Aging Neuroscience

Original Research

Accepted on 04 May 2026

Risk Factors Associated with Cancer and Metabolic Encephalopathy in Alzheimer's Disease Patients

in Alzheimer's Disease and Related Dementias

Danny Pham
Connor O'Brien
Jillian Florez-Bhandari
Nathan Faulstich
Timi Ojo
Sarah Aloi
Rich Goodwin
Laurie Theriot Roley
Samuel I Nathaniel
Thomas I Nathaniel

Frontiers in Aging Neuroscience

Original Research

Published on 04 May 2026

Intracisternal IGF-1 gene delivery attenuates early anxiety-like behavior but not dopaminergic neurodegeneration in a 6-OHDA rat model of parkinsonism

in Neurocognitive Aging and Behavior

Leandro Gabriel Champarini
Macarena Lorena Herrera
Matías Jávega Cometto
Rocío del Valle Bartolozzi
Aracely Janneth Naranjo Viteri
Rosana Crespo
Gastón Diego Calfa
Claudia Beatriz Hereñú

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1781503

415 views

Original Research

Published on 04 May 2026

Integrative bibliometric and transcriptomic analyses identify selenium-associated molecular signatures in the aging brain

in Cellular and Molecular Mechanisms of Brain-aging

Shan Liu
Bo Yan
Han Gao
Lin Zhang
Zihan Zhang
Yaru Liu
Fanglian Chen
Ping Lei

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1791352

385 views

Original Research

Published on 04 May 2026

An eye-tracking-based Stroop test: an efficient method for evaluating frontal lobe function

in Alzheimer's Disease and Related Dementias

Sho Yamamoto
Shuko Takeda
Sho Miki
Shin Teshirogi
Yoshinobu Kishino
Mizuki Katsuhisa
Momoko Okawara
Akane Oyama
Yuki Ito
Tsuneo Nakajima

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1787430

292 views

Original Research

Published on 04 May 2026

Listening for Alzheimer’s clues: machine learning analysis of multidomain speech features for cognitive impairment screening

in Alzheimer's Disease and Related Dementias

Josep Blazquez-Folch
Berta Calm
Adrián Hinojosa-Calleja
Fernando García-Gutiérrez
Montserrat Alegret
Nathalia Muñoz
Amanda Cano
Maria Victoria Fernández
Andrea Miguel
Ariadna Solivar

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1816747

526 views

Mini Review

Accepted on 01 May 2026

Imaging the NeuroHIV Brain in Animal Models: Past, Present, and Future−Toward Longitudinal, Whole-Brain Aging Phenotypes

in Neurocognitive Aging and Behavior

Paddy Ssentongo

Frontiers in Aging Neuroscience

565 views

7,996 articles

articles

Route efficiency in spatial navigation as an early indicator of cognitive decline in amnestic mild cognitive impairment

Transcranial magnetic stimulation from healthy brain aging to Alzheimer’s disease: a review on mechanisms, therapeutic potential, and future clinical directions

Aging modulates amyloid clearance kinetics during anti-amyloid therapy: evidence from real-world serial amyloid PET

Entorhinal cortex atrophy mediates the association of plasma p-tau181, GFAP, and NfL with cognitive impairment in Parkinson’s disease

Application of Neurodegenerative Disease Treatment Strategies in Tinnitus: Mechanisms, Translation, and Prospects

Intranasal administration of stem cells and their derivatives for neurological and respiratory disorders: a systematic review of human clinical trials

Investigating hepatitis E virus seroprevalence in patients with Alzheimer’s disease

Potential for distinguishing the parkinsonian subtype of multiple system atrophy from Parkinson’s disease: a three-dimensional gait analysis study

Food-chain spirochetes: a unified hypothesis for Parkinson’s disease and dementia risk

Predicting time across age: Comparing performance and neural dynamics of younger and older adults in a temporal prediction task

Cognitive Decline and Reduced Bone Mineral Density Under the Bone-Brain Axis: Mechanistic Insights and Imaging Evaluation Strategies

Searching for a needle in a haystack – Ambulatory research in Parkinson`s disease in Germany

Distinct aging-related profiles of allocentric knowledge recall following navigation in an immersive, naturalistic, city-like environment

No associations between blood pressure and brain volumes in a convenience sample of Hispanic/Latino middle-aged and older adults

Correction: Elevated gonadotropins and risk of dementia in Chinese adults aged over 80: a cross-sectional study

Integrating Memory-Guided Saccades and EEG for MCI Screening: A Multimodal LASSO Modeling Approach

Lateralization of interictal epileptic discharges differently impacts cognitive performance and behavior in late-onset epilepsy of unknown aetiology

Editorial: Mitochondrial Dysfunction in Cellular and Molecular Mechanisms of Brain Aging

Risk Factors Associated with Cancer and Metabolic Encephalopathy in Alzheimer's Disease Patients

Intracisternal IGF-1 gene delivery attenuates early anxiety-like behavior but not dopaminergic neurodegeneration in a 6-OHDA rat model of parkinsonism

Integrative bibliometric and transcriptomic analyses identify selenium-associated molecular signatures in the aging brain

An eye-tracking-based Stroop test: an efficient method for evaluating frontal lobe function

Listening for Alzheimer’s clues: machine learning analysis of multidomain speech features for cognitive impairment screening

Imaging the NeuroHIV Brain in Animal Models: Past, Present, and Future−Toward Longitudinal, Whole-Brain Aging Phenotypes