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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Aging Neurosci. | doi: 10.3389/fnagi.2019.00283

Associations between Cognitive Functions and Physical Frailty in Patients with Parkinson’s Disease

 Wei-Che Lin1, 2*, Yu-Chi Huang1, 2, Chau-Peng Leong1, 2, Meng-Hsiang Chen1, 2, Hsiu-Ling Chen1, 2, Nai-Wen Tsa1, 2, Hui-Hsin Tso1, 2, Po-Cheng Chen1, 2 and Cheng-Hsien Lu1, 2
  • 1Kaohsiung Chang Gung Memorial Hospital, Taiwan
  • 2College of Medicine, Chang Gung University, Taiwan

Background: Parkinson’s disease (PD) is a neurodegenerative disease manifested by both motor and non-motor dysfunctions and co-existence of cognitive impairment and physical frailty is common. Given that research in this area is limited, a better understanding of associated factors with physical frailty could provide a focused screening method and facilitate early intervention in PD.
Methods: Seventy-six patients with idiopathic PD were recruited and Fried’s criteria of physical frailty were used to group all participants. Comprehensive cognitive tests and clinical characteristics were measured, and univariate and multivariate analysis was performed to explore the relationship between clinical factors or neuropsychological functions.
Results: Twenty-nine patients with PD (38%) exhibited physical frailty. Compared to PD patients without frailty, PD patients with frailty were older in age and demonstrated worse disease severity and poorer cognitive functions, including attention, executive function, memory, speech and language, and visuospatial function (p < 0.05). Further stepwise logistic regression analysis revealed that disease severity by the Unified Parkinson's Disease Rating Scale (UPDRS) total score (OR: 1.065; 95% CI: 1.033-1.099) and executive function (OR: 0.724; 95% CI: 0.581-0.877) were independent risk factors for predicting physical frailty (p = 0.003 and 0.002). The best cut-off points are 46 in UPDRS (sensitivity: 62.1%; specificity: 91.5%).
Conclusions: Executive function impairment is an independent risk factor for the development of physical frailty with disease progression. Awareness of such comorbidity might provide a screening tool to facilitate investigation in their underlying etiology and early intervention for frailty prevention.

Keywords: cognitive impairment, Executive Function, Physical frailty, Parkinson’s disease, movement disorder

Received: 06 Jun 2019; Accepted: 03 Oct 2019.

Copyright: © 2019 Lin, Huang, Leong, Chen, Chen, Tsa, Tso, Chen and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Wei-Che Lin, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, sub172571@gmail.com