Brief Research Report ARTICLE
VGLUT2 functions as a differential marker for hippocampal output neurons
- 1University of Strathclyde, United Kingdom
- 2Charité Universitätsmedizin Berlin, Germany
The subiculum is the gatekeeper between the hippocampus and cortical areas. Yet, the lack of a pyramidal cell-specific marker gene has made the analysis of the subicular area very difficult. Here we report that the vesicular-glutamate transporter 2 (VGLUT2) functions as a specific marker gene for subicular burst-firing neurons, and demonstrate that VGLUT2-Cre mice allow for Channelrhodopsin-2 (ChR2)-assisted connectivity analysis.
Keywords: Channelrhodopsin-2 (ChR2) assisted circuit mapping, Entorhinal Cortex, Hippocampus, subiculum, Channelrhodopsin (ChR2), Synaptic Transmission, VGLUT2
Received: 05 Jul 2018;
Accepted: 12 Sep 2018.
Edited by:Tommaso Pizzorusso, Consiglio Nazionale Delle Ricerche (CNR), Italy
Reviewed by:Lucas Pozzo-Miller, University of Alabama at Birmingham, United States
Valérie Crépel, Institut National de la Santé et de la Recherche Médicale (INSERM), France
Copyright: © 2018 Wozny, Beed, Nitzan, Pössnecker, Rost and Schmitz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dr. Christian Wozny, University of Strathclyde, Glasgow, United Kingdom, email@example.com