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Glutamatergic Receptors Dynamics and Regulation

Mini Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Mol. Neurosci. | doi: 10.3389/fnmol.2018.00217

Kainate Receptors: Role in Epilepsy

  • 1Department of Physiology, Anatomy and Cell Biology, Universidad Pablo de Olavide, Spain
  • 2University College London, United Kingdom

Kainate (KA) is a potent neurotoxin that has been widely used experimentally to induce acute brain seizures and, after repetitive treatments, as a chronic model of temporal lobe epilepsy (TLE), with similar features to those observed in human patients with TLE. However, whether KA activates KA receptors (KARs) as an agonist to mediate the induction of acute seizures and/or the chronic phase of epilepsy, or whether epileptogenic effects of the neurotoxin are indirect and/or mediated by other type of receptors, has yet to be satisfactorily elucidated. Positing a direct involvement of KARs in acute seizures induction, as well as a direct pathophysiological role of KARs in the chronic phase of TLE, recent studies have examined the specific subunit compositions of KARs that might induce acute seizures and TLE. In the present mini-review, we discuss the use of KA as a convulsant in the experimental models of acute seizures of TLE, and consider the involvement of KARs, their subunit composition and the mode of action in KAR-mediated epilepsy. In acute models, evidence points to epileptogenesis being precipitated by an overall depression of interneuron GABAergic transmission mediated by GluK1 containing KARs. On glutamatergic principal cell in the hippocampus, GluK2-containing KARs regulate postsynaptic excitability and susceptibility to KA-mediated eplileptogenesis. In chronic models, a role GluK2-containing KARs in the hippocampal CA3 region provokes limbic seizures. Also observed in the hippocampus, is a ‘reactive plasticity’ where MF sprouting is seen with target granule cells at aberrant synapses recruiting de novo GluR2/GluR5 heteromeric KARs. Finally, in human epilepsy and animal models, astrocytic expression of GluK1, 2, 4 and 5 is reported.

Keywords: KAR, Epilepsy, CA1, MF, Astrocytes, Dentate Gyrus, recurrent mossy fibers

Received: 20 Mar 2018; Accepted: 04 Jun 2018.

Edited by:

Inmaculada M. Gonzalez-Gonzalez, University of Central Lancashire, United Kingdom

Reviewed by:

Valérie Crépel, Institut National de la Santé et de la Recherche Médicale (INSERM), France
Hana Kubova, Institute of Physiology, Academy of Scences of the Czech Republic  

Copyright: © 2018 Falcón-Moya, Sihra and Rodriguez Moreno. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Antonio Rodriguez Moreno, Universidad Pablo de Olavide, Department of Physiology, Anatomy and Cell Biology, Ctra. de Utrera Km. 1, Sevilla, 41013, Seville, Spain, arodmor@upo.es