Frontiers in Molecular Neuroscience

Editorial

Published on 19 Aug 2026

Editorial: Molecular mechanisms of mental disorders: the contribution of genetic and environmental factors

in Molecular Signalling and Pathways

Martina Di Bartolomeo
Claudio D'Addario

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1937671

347 views

Mini Review

Published on 19 Aug 2026

Epigenetic regulation in medulloblastoma: from tumor heterogeneity to diagnostic, prognostic, and translational applications

in Brain Disease Mechanisms

Xinling Zhang
Lailing Du
Kewei Tian
Lening Chen
Xiaoping Li

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1909580

251 views

Review

Accepted on 18 Aug 2026

Guanfacine and HCN Channels: Bridging Neuroinflammation and Prefrontal Cortex Function in Autism Spectrum Disorder

in Brain Disease Mechanisms

Kazuhiko Yamamuro
Takahira Yamauchi
Manabu Makinodan

Frontiers in Molecular Neuroscience

Review

Published on 18 Aug 2026

Diet–gut microbiota–immune–brain interactions in aging: mechanistic pathways and clinical implications

in Molecular Signalling and Pathways

Maha A. Jarfan
Karani Santhanakrishnan Vimaleswaran
Anisha Wijeyesekera

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1847644

417 views

Review

Published on 18 Aug 2026

The ERK MAPK pathway in mesenchymal glioblastoma: tumorigenesis, microenvironmental reprogramming, and the therapeutic promise of RAS(ON) multi-selective inhibition

in Molecular Signalling and Pathways

Uma M. Basole
Mary M. Fitzpatric
Joseph Donohoe
Shashank Obulasetti
William Snider
Emily Haugen
Damir Garcia
Ana Gonzalez-Manteiga
Mathieu Sertorio
Marc Oria

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1857885

738 views

Original Research

Accepted on 17 Aug 2026

3-hydroxy-3-methylbutyrate (3H3MB) suppresses glioma growth and extends survival in mice

in Brain Disease Mechanisms

Rizwan Khan
Francesco Marrocco
Ottavia Giampaoli
Javeria Maqbool
Alice reccagni
Xingzi Lin
Fabio Sciubba
Adriano Patriarca
Michele De Rosa
Alfredo Miccheli

Frontiers in Molecular Neuroscience

Review

Published on 17 Aug 2026

Temperature-induced structural changes in thermosensitive transient receptor potential channels (thermoTRPs)

in Molecular Signalling and Pathways

Lina Ni

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1911902

338 views

Review

Accepted on 13 Aug 2026

Copper-Regulated Cell Death after Spinal Cord Injury: Evidence Boundaries for Non-Coding RNA, Epigenetics and Cuproptosis

in Brain Disease Mechanisms

Jun Tao
Guobing Wang
Guoying Jiang
Wen-qi Feng
Wen-qi Feng

Frontiers in Molecular Neuroscience

304 views

Brief Research Report

Accepted on 13 Aug 2026

SST Interneuron Maturation Extends Beyond the Second Postnatal Week and Is Driven by Coordinated Transcriptional and Functional Remodeling

in Neuroplasticity and Development

Ourania Christodoulou
Konstantinos Diskos
Angeliki Velli
Panagiotis Moulos
Kyriaki Sidiropoulou
MYRTO DENAXA

Frontiers in Molecular Neuroscience

311 views

Original Research

Accepted on 13 Aug 2026

Cognitive-Behavioral Phenotypes in FMR1 Premutation Carriers: A Cross-Population Comparison with Mild Cognitive Impairment

in Brain Disease Mechanisms

Nell Maltman
Jessica Greenlee
Kimberly Diggle Mueller
Barbara B. Fransway
James T. Shira
Davina Hammann
Sumi Lee
Hyeri Lee
Ali Naderi Malek

Frontiers in Molecular Neuroscience

275 views

Brief Research Report

Published on 13 Aug 2026

Depression of synaptic outputs by reduction of Ca2+ influx, but not RRP vesicles, becomes evident upon CB2R hyper-expression at cerebellar Purkinje cell terminals

in Molecular Signalling and Pathways

Takuma Inoshita
Shin-ya Kawaguchi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1842304

384 views

Original Research

Accepted on 12 Aug 2026

The pERKs of Temporal Order Memory in mice

in Methods and Model Organisms

Santiago D’hers
Santiago Ojea Ramos
Agustina Robles
Mariana Feld

Frontiers in Molecular Neuroscience

302 views

Original Research

Accepted on 12 Aug 2026

Cryopreservation of Human Cortical Organoids Using Vitrification

in Methods and Model Organisms

Kyle Stokes
Sandra Mojica-Perez
Samantha Jacobs
Joy Huang
Shivanshi Vaid
Yukun Yuan
Caroline A Pearson
Daniel Montez
Andrew Tidball
Debora VanHeyningen

Frontiers in Molecular Neuroscience

299 views

Original Research

Accepted on 12 Aug 2026

Molecular abnormalities scale across three models of cerebral injury

in Brain Disease Mechanisms

Volha Liaudanskaya
Matthew J. Robson
Nicole Vike
Sumra Bari
Christopher O'Connell
Orlando Sanguinette Hoilett
David Kaplan
Thomas M Talavage
Eric Nauman
Semyon Slobounov

Frontiers in Molecular Neuroscience

300 views

Original Research

Published on 12 Aug 2026

Transcriptional signatures of aberrant brain functional network topology in chronic low back pain with lumbar disc herniation

in Pain Mechanisms and Modulators

Chuanxu Luo
Wanting Liu
Xiaoyi Liu
Han Xu
Hao Gu
Yapan Zhang
Fengchao Shi
Wenhui Li
Siyu Gu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1790428

382 views

Original Research

Published on 12 Aug 2026

Investigating the role of EFhd2 protein in modulating tau pathology in a tauopathy mouse model

in Brain Disease Mechanisms

Ahlam S. Soliman
Andrew Umstead
Irving E. Vega

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1833887

375 views

Original Research

Published on 12 Aug 2026

GPR4 regulates temporally dynamic and sex-dependent cocaine-induced locomotor sensitization

in Molecular Signalling and Pathways

Eric S. Chai
Dylan Glaser
Joseph Cascone
Grant Brady
Abbas Bader
Christina Cacoulidis
Anshika Kapoor
Emily Yu
Yuyang Chu
Safal Sapkota

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1894955

330 views

Review

Accepted on 11 Aug 2026

Engineering Exosomes in the Treatment of Sensorineural Hearing Loss: From Basic Research to Clinical Applications

in Molecular Signalling and Pathways

Siqi Wang
Juanjuan Li
Bingxing Yang
Mengdi Li
Man Yu
Peng Zhang
Suwen Bai
Xianhai Zeng

Frontiers in Molecular Neuroscience

260 views

Correction

Published on 11 Aug 2026

Correction: Identification and validation of candidate biomarkers associated with mitochondria and 18 types of programmed cell death in trigeminal neuralgia: insights from transcriptome sequencing

in Pain Mechanisms and Modulators

Liqin Gao
Hongchen Shi
Lulu Xi
Xiaohui Liu
Yue Ren
Qiujun Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1932955

326 views

Original Research

Published on 11 Aug 2026

Regulation of Caenorhabditis elegans avoidance behavior toward Pseudomonas aeruginosa PA14 by the canonical Wnt signaling pathway

in Methods and Model Organisms

Rong Lin
Keshu Zhao
Qian Zhang
Xuanxue Xiao
Yuping Zhao
Xin Zhao
Wei Zou

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1851614

458 views

Original Research

Accepted on 10 Aug 2026

Octopamine Receptors in Drosophila Larvae: Expression, Development, and Behavior

in Methods and Model Organisms

Alexandra Großjohann
Vincent Richter
Franziska Reinhardt
Marvin Hahmann
Ronja Badelt
Juliane Kinnigkeit
Jana Breitfeld
Peter Kovacs
Peter F. Stadler
Irene Coin

Frontiers in Molecular Neuroscience

275 views

Original Research

Published on 10 Aug 2026

EIF2S1-PELO co-expression architecture in human brain: pairing-family decomposition reveals constitutive transcriptional coupling and functional layer separation

in Molecular Signalling and Pathways

Drake H. Harbert

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1817096

435 views

Original Research

Published on 10 Aug 2026

Convergent functional networks of intrinsic activity alterations in temporal lobe epilepsy and their molecular correlates

in Brain Disease Mechanisms

Liang-Liang Ma
Ling-Ling Yang
Bao-Zhen Zhou
Qian Gao
Bo-Chao Zheng
Hu-Cheng Yang
Gen-Di Wang
Ting-Ting Yang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1909269

417 views

Original Research

Published on 10 Aug 2026

HGSNAT alleviates oxygen-glucose deprivation- induced endothelial injury by suppressing ER stress: implications for Moyamoya disease

in Molecular Signalling and Pathways

Zhonghui Wen
Bin Hu
Hai Wang
Ziyu Chen
Sen Yang
Fuqing Zhang
Zhiwei Tang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1839595

389 views

4,474 articles

articles

Editorial: Molecular mechanisms of mental disorders: the contribution of genetic and environmental factors

Epigenetic regulation in medulloblastoma: from tumor heterogeneity to diagnostic, prognostic, and translational applications

Guanfacine and HCN Channels: Bridging Neuroinflammation and Prefrontal Cortex Function in Autism Spectrum Disorder

Diet–gut microbiota–immune–brain interactions in aging: mechanistic pathways and clinical implications

The ERK MAPK pathway in mesenchymal glioblastoma: tumorigenesis, microenvironmental reprogramming, and the therapeutic promise of RAS(ON) multi-selective inhibition

3-hydroxy-3-methylbutyrate (3H3MB) suppresses glioma growth and extends survival in mice

Temperature-induced structural changes in thermosensitive transient receptor potential channels (thermoTRPs)

Copper-Regulated Cell Death after Spinal Cord Injury: Evidence Boundaries for Non-Coding RNA, Epigenetics and Cuproptosis

SST Interneuron Maturation Extends Beyond the Second Postnatal Week and Is Driven by Coordinated Transcriptional and Functional Remodeling

Cognitive-Behavioral Phenotypes in FMR1 Premutation Carriers: A Cross-Population Comparison with Mild Cognitive Impairment

Depression of synaptic outputs by reduction of Ca2+ influx, but not RRP vesicles, becomes evident upon CB2R hyper-expression at cerebellar Purkinje cell terminals

The pERKs of Temporal Order Memory in mice

Cryopreservation of Human Cortical Organoids Using Vitrification

Molecular abnormalities scale across three models of cerebral injury

Transcriptional signatures of aberrant brain functional network topology in chronic low back pain with lumbar disc herniation

Investigating the role of EFhd2 protein in modulating tau pathology in a tauopathy mouse model

GPR4 regulates temporally dynamic and sex-dependent cocaine-induced locomotor sensitization

Engineering Exosomes in the Treatment of Sensorineural Hearing Loss: From Basic Research to Clinical Applications

Correction: Identification and validation of candidate biomarkers associated with mitochondria and 18 types of programmed cell death in trigeminal neuralgia: insights from transcriptome sequencing

Regulation of Caenorhabditis elegans avoidance behavior toward Pseudomonas aeruginosa PA14 by the canonical Wnt signaling pathway

Octopamine Receptors in Drosophila Larvae: Expression, Development, and Behavior

EIF2S1-PELO co-expression architecture in human brain: pairing-family decomposition reveals constitutive transcriptional coupling and functional layer separation

Convergent functional networks of intrinsic activity alterations in temporal lobe epilepsy and their molecular correlates

HGSNAT alleviates oxygen-glucose deprivation- induced endothelial injury by suppressing ER stress: implications for Moyamoya disease