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Front. Mol. Neurosci. | doi: 10.3389/fnmol.2018.00451

Neuropeptide Y-Positive Neurons in the Dorosomedial Hypothalamus are Involved in the Anorexic Effect of Angptl8

  • 1Qingdao University, China

Angiopoietin-like protein 8 (Angptl8), a recently identified member of the angiopoietin-like protein family (ANGPTLs), is a 22-kDa peptide synthesized in the liver. It participates in lipid metabolism by inhibiting lipoprotein lipase (LPL) activity, consequently increasing the triglyceride levels. Despite evidence that Angptl8 is involved in feeding control, the underlying mechanisms are unclear. Central and peripheral injections of Angptl8 significantly decreased food intake. Angptl8 was widely expressed in appetite-related nuclei, including the paraventricular nucleus (PVN), the dorsomedial hypothalamus (DMH), the ventromedial hypothalamus, and the arcuate nucleus (ARC) in the hypothalamus. Peripheral Angptl8 administration decreased c-Fos-positive neurons in the DMH. Central Angptl8 administration decreased c-Fos-positive neurons in the DMH and PVN but increased these neurons in the ARC. Angptl8 inhibited appetite via neuropeptide Y (NPY) neurons in the DMH. Furthermore, the chronic administration of Angpt8 decreased body weight gain and altered adipose tissue deposits. Nevertheless, neither peripheral nor central Angptl8 influenced the brown adipose tissue morphology or uncoupling protein 1 (UCP-1) expression in brown adipose tissue (BAT). Taken together, these data suggested that Angptl8 modulates appetite and energy homeostasis.

Keywords: ANGPTL8, Neuropeptid Y, Appetite, Dorsomedial hypothalamic nucleus (DMH), Adipose Tissue

Received: 10 Sep 2018; Accepted: 21 Nov 2018.

Edited by:

Andrew L. Gundlach, Florey Institute of Neuroscience and Mental Health, Australia

Reviewed by:

Garron T. Dodd, Monash University, Australia
Pawel K. Olszewski, University of Waikato, New Zealand  

Copyright: © 2018 Wang, Yuan, Zhang, Wang, Liu, Song, Zhong and Dong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Jing Dong, Qingdao University, Qingdao, China,