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Front. Mol. Neurosci. | doi: 10.3389/fnmol.2019.00081

Combinational treatment of bioscaffolds and extracellular vesicles in spinal cord injury

Xizhi Wang1,  Benson O. Botchway2, Yong Zhang1, Jiaying Yuan1 and  Xuehong Liu1, 3*
  • 1Medical College, Shaoxing University, China
  • 2Institute of Neuroscience, Zhejiang University School of Medicine, Zhejiang University, China
  • 3Department of Histology and Embryology, Medical College, Shaoxing University, China

Spinal cord injury (SCI) can result in an irreversible disability due to loss of sensorimotor function below the lesion. Presently, clinical treatments for SCI mainly include surgery, drugs and postoperative rehabilitation. The prospective roles of bioscaffolds and exosomes in several neurological diseases have been reported. Bioscaffolds can reconnect lesion gaps as well as transport cells and bioactive factors, which in turn can improve axonal and functional regeneration. Herein, we explicate the respective roles of bioscaffolds and exosomes in SCI, and elucidate on the usage of combinational therapy involving bioscaffolds and exosomes in improving SCI.

Keywords: spinal cord injury, Stem Cell Therapy, neuronal damage, functional and axonal regeneration, Bioscaffolds, extracellular vesicles

Received: 24 Jan 2019; Accepted: 14 Mar 2019.

Edited by:

Juan Pablo De Rivero Vaccari, University of Miami, United States

Reviewed by:

Stefano Fais, Istituto Superiore di Sanità (ISS), Italy
Michael Graner, University of Colorado Denver, United States  

Copyright: © 2019 Wang, Botchway, Zhang, Yuan and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Xuehong Liu, Shaoxing University, Department of Histology and Embryology, Medical College, Shaoxing, China, liuxueh6588@126.com