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Front. Mol. Neurosci. | doi: 10.3389/fnmol.2019.00234

The dual role of kinin/kinin receptors system in Alzheimer's disease

  • 1Jining Medical University, China

Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive spatial disorientation, learning and memory deficits, responsible for 60-80% of all dementias. However, the pathological mechanism of AD remains unknown. Numerous studies revealed that kinin/kinin receptors system (KKS) may be involved in the pathophysiology of AD. In this review, we summarized the roles of KKS in neuroinflammation, cerebrovascular impairment, tau phosphorylation, and amyloid beta (Aβ) generation in AD. Moreover, we provide new insights into the mechanistic link between KKS and AD, and highlight the KKS as a potential therapeutic target for AD treatment.

Keywords: Alzheimer's disease,, Amyloid - beta- protein, Kinins receptors, Neuroinflammation, Neuroprotection

Received: 31 May 2019; Accepted: 13 Sep 2019.

Copyright: © 2019 Ji, Wang, Xue, Li and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Bingyuan Ji, Jining Medical University, Jining, China, jby2006@mail.jnmc.edu.cn
Dr. Yilii Wu, Jining Medical University, Jining, China, yili_wu2004@yahoo.ca